Click chemistry in Applications

Copper-catalyzed reaction of an azide with an alkyne to form a 5-membered heteroatom ring, also known as Cu(I)-Catalyzed Azide-Alkyne Cycloaddition (CuAAC), is a powerful reaction for the synthesis of bioconjugates.

Scheme of copper-catalyzed сlick chemistry alkyne azide cycloaddition

Terminal alkyne and azide groups are almost never encountered in natural molecules, so they must be first introduced into the biomolecules to be linked. Alkyne-containing DNA can be prepared with an alkyne phosphoramidite during standard oligo synthesis. Azide or alkyne groups can be attached to proteins by using bifunctional adapter molecules with an NHS ester moiety.

Aqueous DMSO, DMF, acetonitrile, alcohols, or pure water and buffers can be used for the сlick chemistry reaction. The reaction is compatible with a wide range of functional groups.

The following list includes only a few of reagents for сlick chemistry. Please check other categories, especially alkynes and azides.

3-Azidopropylamine

Water-soluble, bifunctional short crosslinker with amino and azide groups.
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58-1g 1 g $145 in stock
58-5g 5 g $490 in stock
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3-Azidopropylamine hydrochloride

A bifunctional short linker with amino and azido groups. A solid, chemically stable hydrochloride form of azidopropylamine. This product is ideal as an azidopropylamine bulk for applications when a large amount of reagent is needed.
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4003-50g 50 g $5990 in stock
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4AZP (4-Azido-L-phenylalanine)

Unnatural L-phenylalanine derivative with an azide moiety for nascent protein synthesis detection via copper-catalyzed and copper-free click chemistry.
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Cat. # Quantity Price Lead time
3415-100mg 100 mg $125 in stock
3415-500mg 500 mg $625 in stock
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5-Ethynyl-uridine (EU)

Uridine alkyne derivative for monitoring and investigation of RNA transcription in cells.
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2439-25mg 25 mg $137 in stock
2439-100mg 100 mg $487 in stock
2439-500mg 500 mg $950 in stock
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Ac4GalNAl (N-(4-pentynoyl)-galactosamine-tetraacylated)

An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
4037-5mg 5 mg $129 in stock
4037-25mg 25 mg $240 in stock
4037-100mg 100 mg $630 in stock
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Ac4GalNAz (N-Azidoacetylgalactosamine-tetraacylated)

An azide-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
3706-5mg 5 mg $129 in stock
3706-25mg 25 mg $240 in stock
3706-100mg 100 mg $630 in stock
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Ac4GlcNAl (N-4-pentynoyl-glucosamine-tetraacylated)

An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
4130-5mg 5 mg $129 in stock
4130-25mg 25 mg $240 in stock
4130-100mg 100 mg $630 in stock
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Ac4GlcNAz (N-Azidoacetylglucosamine-tetraacylated)

An azide-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
3662-5mg 5 mg $129 in stock
3662-25mg 25 mg $240 in stock
3662-100mg 100 mg $630 in stock
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Ac4ManNAl (N-(4-pentynoyl)-mannosamine-tetraacylated)

An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
3431-5mg 5 mg $129 in stock
3431-25mg 25 mg $240 in stock
3431-100mg 100 mg $630 in stock
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Ac4ManNAz (N-Azidoacetylmannosamine-tetraacylated)

An azide-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
3159-5mg 5 mg $129 in stock
3159-25mg 25 mg $240 in stock
3159-100mg 100 mg $630 in stock
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AF 343 (Coumarin)-X-azide

AF 343 (Coumarin) is a blue emitting fluorophore that can serve as a FRET donor for fluorescein (FAM). This azide derivative can be conjugated with alkynes by сlick chemistry. An extended linker arm between the fluorophore and the azide group enhances solubility and provides spatial separation between the dye and the biomolecule.
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Cat. # Quantity Price Lead time
12630 1 mg $105 in stock
22630 5 mg $165 in stock
42630 25 mg $285 in stock
52630 50 mg $495 in stock
62630 100 mg $880 in stock
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AF 384 (PEP) azide

PEP (phenylethynylpyrene), polyaromatic hydrocarbon fluorescent dye for click-chemistry labeling.
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Cat. # Quantity Price Lead time
A4530 1 mg $110 in stock
B4530 5 mg $210 in stock
C4530 10 mg $310 in stock
D4530 25 mg $410 in stock
E4530 50 mg $695 in stock
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AF 430 alkyne

Alkyne derivative of yellow-green fluorescent dye AF 430 for copper-catalyzed click reaction with azides.
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Cat. # Quantity Price Lead time
A08B0 1 mg $125 in stock
B08B0 5 mg $325 in stock
C08B0 10 mg $480 in stock
D08B0 25 mg $950 in stock
E08B0 50 mg $1625 in stock
F08B0 100 mg $2090 in stock
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AF 430 azide

Azide derivative of AF 430 for labeling and detecting alkyne-containing biomolecules via сlick reaction.
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Cat. # Quantity Price Lead time
A0830 1 mg $125 in stock
B0830 5 mg $325 in stock
D0830 25 mg $950 in stock
E0830 50 mg $1625 in stock
F0830 100 mg $2090 in stock
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AF 488 alkyne

Alkyne derivative of AF 488 dye for copper-catalyzed cycloaddition to azides. Pure 5-isomer.
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Cat. # Quantity Price Lead time
A18B0 1 mg $125 in stock
B18B0 5 mg $325 in stock
D18B0 25 mg $950 in stock
E18B0 50 mg $1625 in stock
F18B0 100 mg $2090 in stock
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AF 488 azide

AF 488 azide is a fluorophore with emission in the green spectrum range. It reacts with alkynes in copper-catalyzed cycloaddition reactions.
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Cat. # Quantity Price Lead time
11830 1 mg $125 in stock
21830 5 mg $325 in stock
41830 25 mg $950 in stock
51830 50 mg $1625 in stock
61830 100 mg $2090 in stock
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AF 555 azide

Azide derivative of yellow fluorescent dye AF 555 for сlick сhemistry.
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Cat. # Quantity Price Lead time
1K830 1 mg $140 in stock
2K830 5 mg $450 in stock
4K830 25 mg $1460 in stock
5K830 50 mg $1890 in stock
6K830 100 mg $2640 in stock
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AF 568 alkyne

AF 568 derivative designed for fluorescence microscopy and flow cytometry. Pure 5-isomer.
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Cat. # Quantity Price Lead time
A48B0 1 mg $140 in stock
B48B0 5 mg $450 in stock
C48B0 10 mg $585 in stock
D48B0 25 mg $1460 in stock
E48B0 50 mg $1890 in stock
F48B0 100 mg $2990 in stock
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AF 568 azide

Azide derivative of water-soluble AF 568 dye for labeling alkyne-containing biomolecules and fluorescent visualization of biological objects. Pure 6-isomer.
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Cat. # Quantity Price Lead time
A5820 1 mg $140 in stock
B5820 5 mg $450 in stock
C5820 10 mg $585 in stock
D5820 25 mg $1460 in stock
E5820 50 mg $1890 in stock
F5820 100 mg $2990 in stock
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AF 594 azide

Azide derivative of water-soluble red-fluorescent dye AF 594 for labeling alkyne-containing biomolecules and fluorescent visualization of biological objects. Pure 6-isomer.
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Cat. # Quantity Price Lead time
A7830 1 mg $140 in stock
B7830 5 mg $450 in stock
D7830 25 mg $1460 in stock
E7830 50 mg $1890 in stock
F7830 100 mg $2640 in stock
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AF 647 azide

Bright and photostable azide AF 647 for labeling alkyne-containing biomolecules and fluorescent visualization of biological objects.
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Cat. # Quantity Price Lead time
A6830 1 mg $140 in stock
B6830 5 mg $450 in stock
D6830 25 mg $1460 in stock
E6830 50 mg $1890 in stock
F6830 100 mg $2640 in stock
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AHA (L-Azidohomoalanine)

Noncanonical amino acid analog of methionine with an azide moiety for nascent protein synthesis detection via copper-catalyzed and copper-free click chemistry.
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Cat. # Quantity Price Lead time
3799-25mg 25 mg $125 in stock
3799-100mg 100 mg $235 in stock
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Alkyne amidite, hydroxyprolinol

Acetylenic amidite for the incorporation of acetylene groups into oligos.
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Cat. # Quantity Price Lead time
21360 250 mg $110 in stock
41360 1 g $390 in stock
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Alkyne CPG 1000A

Controlled pore glass solid support for DNA/RNA synthesis with alkyne modification (pore size 1000 Å) for the synthesis of long modified oligonucleotides with 3'-alkyne modification.
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Cat. # Quantity Price Lead time
15860 100 mg $60 in stock
25860 250 mg $120 in stock
35860 500 mg $230 in stock
45860 1 g $380 in stock
55860 5 g $1450 in stock
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Alkyne CPG modifier 500

Solid support for the synthesis of 3'-modified oligonucleotides with alkyne group for Click Chemistry.
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Cat. # Quantity Price Lead time
12860 100 mg $60 in stock
22860 250 mg $120 in stock
32860 500 mg $230 in stock
42860 1 g $380 in stock
52860 5 g $1450 in stock
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Alkyne dT phosphoramidite

Phosphoramidite modifier for the synthesis of oligonucleotides containing alkyne modification in the middle of the chain.
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Cat. # Quantity Price Lead time
1897-100mg 100 mg $330 $195 in stock
1897-1g 1 g $2590 $1250 5 days
1897-5g 5 g $9900 $2850 in stock
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Alkyne dT phosphoramidite

Alkyne dT phosphoramidite is a modifier nucleoside amidite for the synthesis of alkynylated oligonucleotides containing an internal label.
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NO items of this product available in stock but you can submit request for bulk.
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Alkyne hydrazide

Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
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Cat. # Quantity Price Lead time
41770 25 mg $110 in stock
51770 50 mg $195 in stock
61770 100 mg $290 in stock
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Alkyne maleimide

Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
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Cat. # Quantity Price Lead time
41780 25 mg $95 in stock
51780 50 mg $175 in stock
61780 100 mg $200 in stock
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Alkyne phosphoramidite, 5'-terminal

Alkyne phosphoramidite for the synthesis of oligonucleotides ready for click chemistry.
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Cat. # Quantity Price Lead time
22260 250 mg $110 in stock
32260 500 mg $210 in stock
42260 1 g $350 in stock
62260 5 g $1290 in stock
82260 10 g please inquire in stock
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Alkyne-PEG2-amine

Diethyleneglycol (PEG2) based bifunctional linker containing amine and alkyne functional groups.
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Cat. # Quantity Price Lead time
2065-1g 1 g $120 in stock
2065-5g 5 g $350 in stock
2065-25g 25 g please inquire in stock
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Alkyne-PEG2-carboxylic acid

Bifunctional diethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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2155-1g 1 g $380 in stock
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Alkyne-PEG2-iodide

Bifunctional reactive crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling, and reactive alkyl iodide group.
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2136-1g 1 g $450 in stock
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Alkyne-PEG2-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
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