Click chemistry in Applications

The typical click chemistry reaction is the Copper-catalyzed reaction of an azide with an alkyne to form a 5-membered heteroatom ring, it also name a Cu(I)-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). The azide of alkyne functional groups should be specially introduced into DNA and proteins. Alkyne-containing DNA can be prepared with alkyne phosphoramidite during standard oligo synthesis. Proteins labeled with azide and alkyne can be made using azide activated ester and alkyne activated ester. Aqueous DMSO, DMF, acetonitrile, alcohols, or pure water and buffers can be used for the reaction. The reaction is biocompatible and can take place in living cells.

Ascorbic acid

Ascorbic acid for the reduction of Cu(II)-TBTA complex.
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Cat. # Quantity Price Lead time
12050 10 mg $20.00 5 days

Copper(II)-TBTA complex, 10 mM in 55% aq. DMSO

Catalyst for bioconjugate synthesis by Click Chemistry.
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Cat. # Quantity Price Lead time
21050 1.5 mL $55.00 in stock

DMF (dimethylformamide), labeling grade

Dry high purity amine free solvent for NHS ester labeling.
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Cat. # Quantity Price Lead time
13050 1 mL $10.00 in stock

THPTA ligand

THPTA is a water soluble ligand for Cu(I) catalyzed Click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.
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Cat. # Quantity Price Lead time
F4050 100 mg $50.00 5 days
H4050 500 mg $250.00 5 days
I4050 1 g $370.00 in stock

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