Click chemistry in Applications
The typical click chemistry reaction is the Copper-catalyzed reaction of an azide with an alkyne to form a 5-membered heteroatom ring, also known as Cu(I)-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). The azide and alkyne functional groups must first be introduced into the biomolecules to be linked. Alkyne-containing DNA can be prepared with an alkyne phosphoramidite during standard oligo synthesis. Azide or alkyne groups can be attached to proteins by using bifunctional adapter molecules with an NHS ester moiety. Aqueous DMSO, DMF, acetonitrile, alcohols, or pure water and buffers can be used for the reaction. The reaction is biocompatible and can take place in living cells.Ascorbic acid
Ascorbic acid for the reduction of Cu(II)-TBTA complex.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 12050 | 10 mg | $20.00 | 5 days |
Copper(II)-TBTA complex, 10 mM in 55% aq. DMSO
Catalyst for bioconjugate synthesis by Click Chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 21050 | 1.5 mL | $55.00 | stock |
DMF (dimethylformamide), labeling grade
Dry high purity amine free solvent for NHS ester labeling.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 13050 | 1 mL | $10.00 | stock |
Sulfo-Cyanine7.5 azide
Sulfo-Cyanine7.5 is a very hydrophilic and water soluble dye for the near infrared region. The absorption and emission spectra of the dye are similar to indocyanine green (ICG), but sulfo-Cyanine7.5 has a much higher fluorescence quantum yield. The dye is a great choice for near infrared in vivo imaging. This is an azide for Click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A6330 | 1 mg | $110.00 | stock | |
| B6330 | 5 mg | $290.00 | stock | |
| C6330 | 10 mg |
$470.00 |
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| D6330 | 25 mg |
$690.00 |
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| E6330 | 50 mg |
$1270.00 |
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| F6330 | 100 mg |
$1990.00 |
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THPTA ligand
THPTA is a water soluble ligand for Cu(I) catalyzed Click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| F4050 | 100 mg | $50.00 | stock | |
| H4050 | 500 mg | $250.00 | stock | |
| I4050 | 1 g | $370.00 | stock |
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