Click chemistry in Applications
Copper-catalyzed reaction of an azide with an alkyne to form a 5-membered heteroatom ring, also known as Cu(I)-Catalyzed Azide-Alkyne Cycloaddition (CuAAC), is a powerful reaction for the synthesis of bioconjugates.
Terminal alkyne and azide groups are almost never encountered in natural molecules, so they must be first introduced into the biomolecules to be linked. Alkyne-containing DNA can be prepared with an alkyne phosphoramidite during standard oligo synthesis. Azide or alkyne groups can be attached to proteins by using bifunctional adapter molecules with an NHS ester moiety.
Aqueous DMSO, DMF, acetonitrile, alcohols, or pure water and buffers can be used for the сlick chemistry reaction. The reaction is compatible with a wide range of functional groups.
The following list includes only a few of reagents for сlick chemistry. Please check other categories, especially alkynes and azides.
3-Azidopropylamine
Bifunctional short crosslinker with an aminogroup and azide group.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 58-1g | 1 g | $145.00 | in stock | |
| 58-5g | 5 g |
$490.00
|
in stock |
AF488 alkyne, 5-isomer
Alkyne derivative of AF488 dye for copper-catalyzed cycloaddition to azides (CuAAC).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A18B0 | 1 mg | $110.00 | in stock | |
| B18B0 | 5 mg | $290.00 | in stock | |
| D18B0 | 25 mg |
$690.00
|
in stock | |
| E18B0 | 50 mg |
$1270.00
|
in stock | |
| F18B0 | 100 mg |
$1990.00
|
in stock |
AF647 azide
Bright and photostable azide AF647 for labeling alkyne-containing biomolecules and fluorescent visualization of biological objects.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A6830 | 1 mg | $110.00 | in stock | |
| B6830 | 5 mg | $340.00 | in stock | |
| D6830 | 25 mg |
$1100.00
|
in stock | |
| E6830 | 50 mg |
$1890.00
|
in stock | |
| F6830 | 100 mg |
$2990.00
|
in stock |
Ascorbic acid
Ascorbic acid for the reduction of Cu(II)-TBTA complex.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 12050 | 10 mg | $20.00 | in stock |
Azide-PEG3-Amine
A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 218-1g | 1 g | $95.00 | in stock | |
| 218-5g | 5 g | $280.00 | in stock | |
| 218-25g | 25 g |
please inquire
|
in stock |
Azide-PEG3-Azide
Triethylene glycol diazide (CAS# 59559-06-7) is a bifunctional crosslinker bearing two azide groups. Suitable for Click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 207-1g | 1 g | $95.00 | in stock | |
| 207-5g | 5 g | $390.00 | in stock | |
| 207-25g | 25 g |
please inquire
|
in stock |
Azide-PEG4-Amine
PEG4 amine azide (CAS# 134179-38-7) is a bifunctional linker with amine and azide functional groups. It is based on a tetraethyleneglycol core. The length of the PEG4 linker is 1.4 nm.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1868-1g | 1 g | $90.00 | in stock | |
| 1868-5g | 5 g | $250.00 | in stock | |
| 1868-25g | 25 g |
$950.00
|
in stock |
Azide-PEG4-Azide
PEG4 diazide (CAS# 101187-39-7) is a homobifunctional linker with two azide groups. It can be used for the synthesis of dimeric molecules with a hydrophilic core by Click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1865-1g | 1 g | $90.00 | in stock | |
| 1865-5g | 5 g | $250.00 | in stock | |
| 1865-25g | 25 g |
$950.00
|
in stock |
BDP 558/568 azide
BDP 558/568 is a borondipyrromethene fluorophore with absorption and emission spectra close to Cyanine3. This is an azide derivative for сlick chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 17430 | 1 mg | $110.00 | in stock | |
| 27430 | 5 mg | $210.00 | in stock | |
| 37430 | 10 mg | $310.00 | in stock | |
| 47430 | 25 mg |
$410.00
|
in stock | |
| 57430 | 50 mg |
$695.00
|
in stock | |
| 67430 | 100 mg |
please inquire
|
in stock |
Click chemistry buffer, 1.5x
Catalytic buffer for Click chemistry modification of nucleic acids and small molecules.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 61150 | 55 mL | $49.00 | in stock |
Copper(II)-TBTA complex
A catalyst for click reaction. A stable copper(II) complex that must be converted to monovalent copper(I) in situ using reducing agents.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 21050 | 1.5 mL | $55.00 | in stock |
DMSO, labeling grade
Pure dimethyl sulfoxide (DMSO) solvent with quality optimised for Click and other cojugation reactions
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 15050 | 1 mL | $10.00 | in stock |
EdU (5-ethynyl-2'-deoxyuridine)
EdU is a nucleoside which is incorporated into replicated DNA by cellular enzymes. After it, DNA contained in the cells can be developed by Click chemistry reaction with fluorescent dye azides to reveal cell proliferation.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 10540 | 100 mg | $120.00 | in stock | |
| 20540 | 250 mg | $195.00 | in stock | |
| 30540 | 500 mg | $345.00 | in stock | |
| 40540 | 1 g |
$590.00
|
in stock | |
| 60540 | 5 g |
please inquire
|
10 days |
endo-BCN CE-Phosphoramidite
BCN-containing phosphoramidite for the synthesis of oligonucleotides and their labeling using copper-free click reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3005-250mg | 250 mg |
$800.00
|
5 days | |
| 3005-1g | 1 g |
$2350.00
|
in stock |
THPTA ligand
THPTA is a water soluble ligand for Cu(I) catalyzed Click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| F4050 | 100 mg | $40.00 | in stock | |
| H4050 | 500 mg | $199.00 | in stock | |
| I4050 | 1 g | $369.00 | in stock | |
| K4050 | 5 g |
$1568.00
|
in stock |
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