Click chemistry in Applications
Copper-catalyzed reaction of an azide with an alkyne to form a 5-membered heteroatom ring, also known as Cu(I)-Catalyzed Azide-Alkyne Cycloaddition (CuAAC), is a powerful reaction for the synthesis of bioconjugates.
Terminal alkyne and azide groups are almost never encountered in natural molecules, so they must be first introduced into the biomolecules to be linked. Alkyne-containing DNA can be prepared with an alkyne phosphoramidite during standard oligo synthesis. Azide or alkyne groups can be attached to proteins by using bifunctional adapter molecules with an NHS ester moiety.
Aqueous DMSO, DMF, acetonitrile, alcohols, or pure water and buffers can be used for the сlick chemistry reaction. The reaction is compatible with a wide range of functional groups.
The following list includes only a few of reagents for сlick chemistry. Please check other categories, especially alkynes and azides.
Ac4GlcNAz (N-Azidoacetylglucosamine-tetraacylated)
An azide-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3662-5mg | 5 mg | $110.00 | in stock | |
| 3662-25mg | 25 mg | $190.00 | in stock | |
| 3662-100mg | 100 mg |
$580.00
|
in stock |
3-Azidopropylamine
Water-soluble, bifunctional short crosslinker with amino and azide groups.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 58-1g | 1 g | $145.00 | in stock | |
| 58-5g | 5 g |
$490.00
|
in stock |
3-Azidopropylamine hydrochloride
A bifunctional short linker with amino and azido groups. A solid, chemically stable hydrochloride form of azidopropylamine. This product is ideal as an azidopropylamine bulk for applications when a large amount of reagent is needed.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4003-50g | 50 g |
$5990.00
|
in stock |
Ac4GalNAz (N-Azidoacetylgalactosamine-tetraacylated)
An azide-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3706-5mg | 5 mg | $90.00 | in stock | |
| 3706-25mg | 25 mg | $190.00 | in stock | |
| 3706-100mg | 100 mg |
$580.00
|
in stock |
Ac4ManNAl (N-(4-pentynoyl)-mannosamine-tetraacylated)
An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3431-5mg | 5 mg | $110.00 | 7 days | |
| 3431-25mg | 25 mg | $190.00 | 7 days | |
| 3431-100mg | 100 mg |
$580.00
|
7 days |
Ac4ManNAz (N-Azidoacetylmannosamine-tetraacylated)
An azide-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3159-5mg | 5 mg | $110.00 | in stock | |
| 3159-25mg | 25 mg | $190.00 | in stock | |
| 3159-100mg | 100 mg |
$580.00
|
in stock |
AF 430 alkyne
Alkyne derivative of yellow-green fluorescent dye AF 430 for copper-catalyzed click reaction with azides.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A08B0 | 1 mg | $110.00 | in stock | |
| B08B0 | 5 mg | $290.00 | in stock | |
| C08B0 | 10 mg |
$470.00
|
in stock | |
| D08B0 | 25 mg |
$690.00
|
in stock | |
| E08B0 | 50 mg |
$1270.00
|
in stock | |
| F08B0 | 100 mg |
$1990.00
|
in stock |
AF 430 azide
Azide derivative of AF 430 for labeling and detecting alkyne-containing biomolecules via сlick reaction.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A0830 | 1 mg | $110.00 | in stock | |
| B0830 | 5 mg | $290.00 | in stock | |
| D0830 | 25 mg |
$690.00
|
in stock | |
| E0830 | 50 mg |
$1270.00
|
in stock | |
| F0830 | 100 mg |
$1990.00
|
in stock |
AF 488 alkyne
Alkyne derivative of AF 488 dye for copper-catalyzed cycloaddition to azides. Pure 5-isomer.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A18B0 | 1 mg | $110.00 | in stock | |
| B18B0 | 5 mg | $290.00 | in stock | |
| D18B0 | 25 mg |
$690.00
|
in stock | |
| E18B0 | 50 mg |
$1270.00
|
in stock | |
| F18B0 | 100 mg |
$1990.00
|
in stock |
AF 488 azide
AF 488 azide is a fluorophore with emission in the green spectrum range. It reacts with alkynes in copper-catalyzed cycloaddition reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 11830 | 1 mg | $110.00 | in stock | |
| 21830 | 5 mg | $290.00 | in stock | |
| 41830 | 25 mg |
$690.00
|
in stock | |
| 51830 | 50 mg |
$1270.00
|
in stock | |
| 61830 | 100 mg |
$1990.00
|
in stock |
AF 555 azide
Azide derivative of yellow fluorescent dye AF 555 for сlick сhemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1K830 | 1 mg | $120.00 | in stock | |
| 2K830 | 5 mg |
$400.00
|
in stock | |
| 4K830 | 25 mg |
$1210.00
|
in stock | |
| 5K830 | 50 mg |
$1710.00
|
in stock | |
| 6K830 | 100 mg |
$2425.00
|
in stock |
AF 568 alkyne
AF 568 derivative designed for fluorescence microscopy and flow cytometry. Pure 5-isomer.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A48B0 | 1 mg | $110.00 | in stock | |
| B48B0 | 5 mg | $290.00 | in stock | |
| C48B0 | 10 mg |
$470.00
|
in stock | |
| D48B0 | 25 mg |
$690.00
|
in stock | |
| E48B0 | 50 mg |
$1270.00
|
in stock | |
| F48B0 | 100 mg |
$1990.00
|
in stock |
AF 568 azide
Azide derivative of water-soluble AF 568 dye for labeling alkyne-containing biomolecules and fluorescent visualization of biological objects. Pure 6-isomer.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A5820 | 1 mg | $110.00 | in stock | |
| B5820 | 5 mg | $290.00 | in stock | |
| C5820 | 10 mg |
$470.00
|
in stock | |
| D5820 | 25 mg |
$690.00
|
in stock | |
| E5820 | 50 mg |
$1270.00
|
in stock | |
| F5820 | 100 mg |
$1990.00
|
in stock |
AF 594 azide
Azide derivative of water-soluble red-fluorescent dye AF 594 for labeling alkyne-containing biomolecules and fluorescent visualization of biological objects. Pure 6-isomer.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A7830 | 1 mg | $110.00 | in stock | |
| B7830 | 5 mg | $340.00 | in stock | |
| D7830 | 25 mg |
$1100.00
|
in stock | |
| E7830 | 50 mg |
$1890.00
|
in stock | |
| F7830 | 100 mg |
$2990.00
|
in stock |
AF 647 azide
Bright and photostable azide AF 647 for labeling alkyne-containing biomolecules and fluorescent visualization of biological objects.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A6830 | 1 mg | $110.00 | in stock | |
| B6830 | 5 mg | $340.00 | in stock | |
| D6830 | 25 mg |
$1100.00
|
in stock | |
| E6830 | 50 mg |
$1890.00
|
in stock | |
| F6830 | 100 mg |
$2990.00
|
in stock |
Alkyne amidite, hydroxyprolinol
Acetylenic amidite for the incorporation of acetylene groups into oligos.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 21360 | 250 mg | $110.00 | in stock | |
| 41360 | 1 g | $390.00 | in stock |
Alkyne CPG 1000A
Controlled pore glass solid support for DNA/RNA synthesis with alkyne modification (pore size 1000 Å) for the synthesis of long modified oligonucleotides with 3'-alkyne modification.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 15860 | 100 mg | $60.00 | in stock | |
| 25860 | 250 mg | $120.00 | in stock | |
| 35860 | 500 mg | $230.00 | in stock | |
| 45860 | 1 g | $380.00 | in stock | |
| 55860 | 5 g |
$1450.00
|
in stock |
Alkyne CPG modifier 500
Solid support for the synthesis of 3'-modified oligonucleotides with alkyne group for Click Chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 12860 | 100 mg | $60.00 | in stock | |
| 22860 | 250 mg | $120.00 | in stock | |
| 32860 | 500 mg | $230.00 | in stock | |
| 42860 | 1 g | $380.00 | in stock | |
| 52860 | 5 g |
$1450.00
|
in stock |
Alkyne dT phosphoramidite
Phosphoramidite modifier for the synthesis of oligonucleotides containing alkyne modification in the middle of the chain.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1897-100mg | 100 mg | $330.00 | in stock | |
| 1897-1g | 1 g |
$2590.00
|
in stock | |
| 1897-5g | 5 g |
$9900.00
|
in stock |
Alkyne dT phosphoramidite
Alkyne dT phosphoramidite is a modifier nucleoside amidite for the synthesis of alkynylated oligonucleotides containing an internal label.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| NO items of this product available in stock but you can submit request for bulk. | ||||
Alkyne hydrazide
Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 41770 | 25 mg | $110.00 | in stock | |
| 51770 | 50 mg | $195.00 | in stock | |
| 61770 | 100 mg | $290.00 | in stock |
Alkyne maleimide
Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 41780 | 25 mg | $95.00 | in stock | |
| 51780 | 50 mg | $175.00 | in stock | |
| 61780 | 100 mg | $200.00 | in stock |
Alkyne phosphoramidite, 5'-terminal
Alkyne phosphoramidite for the synthesis of oligonucleotides ready for click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 22260 | 250 mg | $110.00 | in stock | |
| 32260 | 500 mg | $190.00 | in stock | |
| 42260 | 1 g | $310.00 | in stock | |
| 62260 | 5 g |
$1290.00
|
in stock | |
| 82260 | 10 g | please inquire | in stock |
Alkyne-PEG2-amine
Diethyleneglycol (PEG2) based bifunctional linker containing amine and alkyne functional groups.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2065-1g | 1 g | $120.00 | in stock | |
| 2065-5g | 5 g | $350.00 | in stock | |
| 2065-25g | 25 g | please inquire | in stock |
Alkyne-PEG2-carboxylic acid
Bifunctional diethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2155-1g | 1 g | $380.00 | in stock |
Alkyne-PEG2-iodide
Bifunctional reactive crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling, and reactive alkyl iodide group.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2136-1g | 1 g |
$450.00
|
in stock |
Alkyne-PEG2-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2219-1g | 1 g |
$450.00
|
in stock | |
| 2219-5g | 5 g |
$980.00
|
in stock |
Alkyne-PEG3-amine
Alkyne-PEG3-amine is a medium-length heterobifunctional linker for conjugation.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 425-1g | 1 g | $195.00 | in stock | |
| 425-5g | 5 g |
$580.00
|
in stock | |
| 425-25g | 25 g | please inquire | in stock |
Alkyne-PEG3-carboxylic acid
Bifunctional triethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1743-1g | 1 g |
$490.00
|
in stock | |
| 1743-5g | 5 g |
$980.00
|
in stock | |
| 1743-25g | 25 g | please inquire | in stock |
Alkyne-PEG3-iodide
PEG3 with alkyne and iodide functional groups, a reactive and hydrophilic linker for alkylation and click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2193-1g | 1 g |
$490.00
|
in stock | |
| 2193-5g | 5 g |
$1150.00
|
in stock | |
| 2193-25g | 25 g | please inquire | in stock |
Alkyne-PEG3-maleimide
Bifunctional spacer with alkyne and maleimide groups.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2344-100mg | 100 mg | $140.00 | in stock | |
| 2344-1g | 1 g |
$530.00
|
in stock |
Alkyne-PEG3-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2298-1g | 1 g |
$490.00
|
in stock | |
| 2298-5g | 5 g |
$980.00
|
in stock |
Alkyne-PEG3-OH
Alkyne-PEG3-OH is a triethyleneglycol based bifunctional linker with a hydroxyl group and an alkyne fragment.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 418-1g | 1 g | $95.00 | in stock | |
| 418-5g | 5 g | $280.00 | in stock | |
| 418-25g | 25 g | please inquire | in stock |
Alkyne-PEG4-amine
A bifunctional linker molecule containing both terminal alkyne moiety for click chemistry, and amine group. Contains a long hydrophilic PEG4 arm.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2025-100mg | 100 mg | $95.00 | in stock | |
| 2025-1g | 1 g | $390.00 | in stock |
Alkyne-PEG4-carboxylic acid
Bifunctional tetraethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2187-1g | 1 g | $380.00 | in stock |
Alkyne-PEG4-iodide
Bifunctional reactive PEG4-based crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling and reactive alkyl iodide group.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2188-1g | 1 g |
$450.00
|
in stock |
Alkyne-PEG4-maleimide
Water soluble, heterobifunctional hydrophilic linker with a length of 14 Å, containing maleimide for thiol labeling, and alkyne for click chemistry. An ideal reagent to attach an alkyne moiety to a protein.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2002-100mg | 100 mg | $150.00 | in stock | |
| 2002-1g | 1 g |
$590.00
|
in stock |
Alkyne-PEG4-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2409-100mg | 100 mg | $250.00 | 5 days | |
| 2409-1g | 1 g |
$790.00
|
in stock |
Alkyne-PEG4-phosphoramidite
Alkyne phosphoramidite for conjugation of oligonucleotides with biomolecules.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2779-100mg | 100 mg | $390.00 | in stock | |
| 2779-250mg | 250 mg |
$680.00
|
in stock | |
| 2779-1g | 1 g |
$1640.00
|
in stock | |
| 2779-5g | 5 g | please inquire | in stock |