Cycloalkenes are strained alkenes, tetrazine-reactive derivatives for inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).

Trans-cyclooctene (TCO) is one of the most used cycloalkenes for bioconjugation tasks. TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, high yielding, and long-term aqueous stability, which is important in low-concentration applications such as dye-protein conjugations, etc.

AF 488 TCO

AF 488-containing derivative of trans-cyclooctene (TCO) for conjugation with tetrazine via the inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).
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Cat. # Quantity Price Lead time
118H0 1 mg $199 in stock
218H0 5 mg $649 in stock
418H0 25 mg $1789 in stock
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