Cycloalkenes

Cycloalkenes are strained alkenes, tetrazine-reactive derivatives for inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).

Trans-cyclooctene (TCO) is one of the most used cycloalkenes for bioconjugation tasks. TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, high yielding, and long-term aqueous stability, which is important in low-concentration applications such as dye-protein conjugations, etc.

AF 488 TCO

AF 488-containing derivative of trans-cyclooctene (TCO) for conjugation with tetrazine via the inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).
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Cat. # Quantity Price Lead time
118H0 1 mg
$339.90
in stock
218H0 5 mg
$1199.00
in stock
418H0 25 mg
$3099.00
in stock
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AF 568 TCO

AF 568 TCO is a bright, photostable dye bearing a trans-cyclooctene (TCO) handle for rapid bioorthogonal labeling of tetrazine-modified biomolecules in live or fixed samples.
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Cat. # Quantity Price Lead time
148H0 1 mg
$318.00
in stock
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AF 647 TCO

A derivative of the AF 647 fluorophore functionalized with trans-cyclooctene (TCO) for rapid and highly selective bioorthogonal conjugation to tetrazine-containing molecules.
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Cat. # Quantity Price Lead time
1G8H0 1 mg
$196.00
in stock
2G8H0 5 mg
$528.00
in stock
4G8H0 25 mg
$1680.00
in stock
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BDP® FL TCO

A green-fluorescent dye functionalized with a trans-cyclooctene (TCO) moiety for rapid and selective bioorthogonal conjugation.
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Cat. # Quantity Price Lead time
214H0 5 mg
$490.00
in stock
314H0 10 mg
$790.00
in stock
414H0 25 mg
$1550.00
in stock
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Cyanine3B TCO

Derivative of the Cyanine3B dye functionalized with trans-cyclooctene (TCO) for rapid and selective conjugation to tetrazine-containing biomolecules.
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Cat. # Quantity Price Lead time
139H0 1 mg
$590.00
in stock
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sulfo-Cyanine5 TCO

A water-soluble far-red fluorescent dye functionalized with a trans-cyclooctene group for rapid and highly selective bioorthogonal labeling of tetrazine-containing biomolecules under mild conditions.
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Cat. # Quantity Price Lead time
133H0 1 mg
$290.00
in stock
233H0 5 mg
$348.00
in stock
333H0 10 mg
$578.00
in stock
433H0 25 mg
$1220.00
in stock
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sulfo-Cyanine7 TCO

A bright near-infrared (NIR) fluorescent dye functionalized with a trans-cyclooctene (TCO) moiety for rapid, catalyst-free bioorthogonal labeling of tetrazine-containing biomolecules.
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Cat. # Quantity Price Lead time
153H0 1 mg
$290.00
in stock
253H0 5 mg
$348.00
in stock
353H0 10 mg
$578.00
in stock
453H0 25 mg
$1220.00
in stock
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