Crosslinking in Applications

Bifunctional crosslinkers are molecules that contain two functional groups, either identical, or different, for the synthesis of conjugates of biomolecules.

Lumiprobe offers a range of bifunctional crosslinker molecules that contain various terminal reactive groups flanking different linkers, including short alkyls, and longer polyethylene glycols (PEGs).

3-Azidopropanol

Azidopropanol is a short bifunctional linker compound with azide and hydroxyl functional groups.
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1419-1g 1 g $310 in stock
1419-5g 5 g $650 in stock
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3-Azidopropylamine

Water-soluble, bifunctional short crosslinker with amino and azide groups.
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58-1g 1 g $145 in stock
58-5g 5 g $490 in stock
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3-Azidopropylamine hydrochloride

A bifunctional short linker with amino and azido groups. A solid, chemically stable hydrochloride form of azidopropylamine. This product is ideal as an azidopropylamine bulk for applications when a large amount of reagent is needed.
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4003-50g 50 g $5990 in stock
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3-Maleimidopropionic acid NHS-ester

Bifunctional crosslinker with an amine-reactive succinimidyl ester and a thiol-reactive maleimide group.
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3419-500mg 500 mg $110 in stock
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Alkyne hydrazide

Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
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Cat. # Quantity Price Lead time
41770 25 mg $110 in stock
51770 50 mg $195 in stock
61770 100 mg $290 in stock
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Alkyne maleimide

Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
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Cat. # Quantity Price Lead time
41780 25 mg $95 in stock
51780 50 mg $175 in stock
61780 100 mg $200 in stock
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Alkyne-PEG2-amine

Diethyleneglycol (PEG2) based bifunctional linker containing amine and alkyne functional groups.
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2065-1g 1 g $120 in stock
2065-5g 5 g $350 in stock
2065-25g 25 g please inquire in stock
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Alkyne-PEG2-carboxylic acid

Bifunctional diethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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2155-1g 1 g $380 in stock
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Alkyne-PEG2-iodide

Bifunctional reactive crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling, and reactive alkyl iodide group.
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2136-1g 1 g $450 in stock
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Alkyne-PEG2-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
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2219-1g 1 g $450 in stock
2219-5g 5 g $980 in stock
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Alkyne-PEG3-amine

Alkyne-PEG3-amine is a medium-length heterobifunctional linker for conjugation.
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425-1g 1 g $195 in stock
425-5g 5 g $580 in stock
425-25g 25 g please inquire in stock
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Alkyne-PEG3-carboxylic acid

Bifunctional triethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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1743-1g 1 g $490 in stock
1743-5g 5 g $980 in stock
1743-25g 25 g please inquire in stock
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Alkyne-PEG3-maleimide

Bifunctional spacer with alkyne and maleimide groups for conjugation of biomolecules.
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2344-100mg 100 mg $140 in stock
2344-1g 1 g $530 in stock
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Alkyne-PEG3-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
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2298-1g 1 g $490 in stock
2298-5g 5 g $980 in stock
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Alkyne-PEG3-OH

Alkyne-PEG3-OH is a triethyleneglycol based bifunctional linker with a hydroxyl group and an alkyne fragment.
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418-1g 1 g $95 in stock
418-5g 5 g $280 in stock
418-25g 25 g please inquire in stock
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Alkyne-PEG4-amine

A bifunctional linker molecule containing both terminal alkyne moiety for click chemistry, and amine group. Contains a long hydrophilic PEG4 arm.
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2025-100mg 100 mg $95 in stock
2025-1g 1 g $390 in stock
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Alkyne-PEG4-carboxylic acid

Bifunctional tetraethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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2187-1g 1 g $380 in stock
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Alkyne-PEG4-iodide

Bifunctional reactive PEG4-based crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling and reactive alkyl iodide group.
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2188-1g 1 g $450 in stock
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Alkyne-PEG4-maleimide

Water soluble, heterobifunctional hydrophilic linker with a length of 14 Å, containing maleimide for thiol labeling, and alkyne for click chemistry. An ideal reagent to attach an alkyne moiety to a protein.
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Cat. # Quantity Price Lead time
2002-100mg 100 mg $150 in stock
2002-1g 1 g $590 in stock
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Alkyne-PEG4-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
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Cat. # Quantity Price Lead time
2409-100mg 100 mg $250 in stock
2409-1g 1 g $790 in stock
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Amine-PEG2-carboxylic acid

Hydrophilic PEG2-linker with a terminal amino group and a carboxyl group.
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2817-250mg 250 mg $90 in stock
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Amine-PEG3-carboxylic acid

Hydrophilic PEG3-linker with a terminal amino group and a carboxyl group.
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Cat. # Quantity Price Lead time
2616-250mg 250 mg $90 in stock
2616-1g 1 g $230 in stock
2616-2g 2 g $390 in stock
2616-5g 5 g $690 in stock
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Amine-PEG3-OH

Bifunctional PEG3 derivative with amine and hydroxyl groups.
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Cat. # Quantity Price Lead time
2774-1g 1 g $190 in stock
2774-5g 5 g $490 in stock
2774-25g 25 g please inquire in stock
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Amine-PEG4-OH

A hydrophilic tetraethylene glycol derivative with terminal amino and hydroxyl groups.
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2473-1g 1 g $190 in stock
2473-5g 5 g $490 in stock
2473-25g 25 g please inquire in stock
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Azide-PEG2-aldehyde

Bifunctional linker with azide group and aliphatic aldehyde moiety.
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Azide-PEG2-amine

A diethylene glycol (PEG2) linker with azide and amino groups.
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Cat. # Quantity Price Lead time
2581-1g 1 g $110 in stock
2581-5g 5 g $260 in stock
2581-10g 10 g $390 in stock
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Azide-PEG2-carboxylic acid

Bifunctional diethylene glycol with terminal carboxyl and azido groups.
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2816-250mg 250 mg $230 in stock
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Azide-PEG2-iodide

A bifunctional molecule containing hydrophilic PEG2 with azide and iodide groups.
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2636-250mg 250 mg $290 in stock
2636-500mg 500 mg $430 in stock
2636-1g 1 g please inquire in stock
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Azide-PEG3-amine

A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)
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218-1g 1 g $95 in stock
218-5g 5 g $280 in stock
218-25g 25 g please inquire in stock
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Azide-PEG3-azide

Triethylene glycol diazide is a bifunctional crosslinker bearing two azide groups. Suitable for click chemistry.
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207-1g 1 g $95 in stock
207-5g 5 g $390 in stock
207-25g 25 g please inquire in stock
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Azide-PEG3-carboxylic acid

Bifunctional triethylene glycol with terminal carboxyl and azido groups.
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2558-1g 1 g $265 in stock
2558-5g 5 g $950 in stock
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Azide-PEG3-chloride

Azide-PEG3-chloride contains a reactive halogen atom and an azide group for click chemistry reaction. It can also serve as a protected amine group equivalent.
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2106-1g 1 g $490 in stock
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Azide-PEG3-iodide

Azide-PEG3-iodide is a bifunctional linker with a highly reactive alkylative halogen functional group and an azido group for click chemistry or Staudinger ligation.
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Cat. # Quantity Price Lead time
2163-1g 1 g $290 in stock
2163-5g 5 g $590 in stock
2163-25g 25 g please inquire in stock
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Azide-PEG3-OH

Azide-PEG3-OH is a bifunctional molecule with an azide group, primary alcohol, and a hydrophilic PEG3 linker in between.
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1742-1g 1 g $90 in stock
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Azide-PEG3-tetrazine

A hydrophilic bifunctional linker with azide and tetrazine function groups flanking PEG3 (triethylene glycol) spacer.
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2798-250mg 250 mg $549 in stock
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Azide-PEG4-amine

PEG4 amine azide is a bifunctional linker with amine and azide functional groups. It is based on a tetraethyleneglycol core. The length of the PEG4 linker is 1.4 nm.
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Cat. # Quantity Price Lead time
1868-1g 1 g $90 in stock
1868-5g 5 g $250 in stock
1868-25g 25 g please inquire in stock
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Azide-PEG4-azide

PEG4 diazide is a homobifunctional linker with two azide groups. It can be used for the synthesis of dimeric molecules with a hydrophilic core by click chemistry.
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1865-1g 1 g $90 in stock
1865-5g 5 g $250 in stock
1865-25g 25 g $950 in stock
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Azide-PEG6-NHS ester

A hydrophilic bifunctional linker with azide and NHS ester function groups flanking PEG6 (hexaethylene glycol).
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Cat. # Quantity Price Lead time
3692-250mg 250 mg $325 in stock
3692-1g 1 g $539 in stock
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Azidobutyric acid NHS ester

Activated NHS ester for azido-labeling of peptides and proteins.
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Cat. # Quantity Price Lead time
53720 50 mg $110 in stock
63720 100 mg $210 in stock
73720 1 g $950 in stock
83720 5 g please inquire in stock
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BCN-PEG4-Cyanine3 (exo)

BCN-PEG4-Cyanine3 is an ethylene glycol separated linker for the azido-modified molecules for copper-free click conjugation.
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Cat. # Quantity Price Lead time
3269-1mg 1 mg $105 21 days
3269-5mg 5 mg $295 in stock
3269-50mg 50 mg $2500 in stock
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Cyanine7 dicarboxylic acid

Cyanine7 dicarboxylic acid is a bifunctional dye molecule possessing two carboxylic acid groups.
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Cat. # Quantity Price Lead time
1512-1mg 1 mg $125 in stock
1512-5mg 5 mg $260 in stock
1512-25mg 25 mg $510 in stock
1512-50mg 50 mg $895 in stock
1512-100mg 100 mg $1490 in stock
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DBCO amine trifluoroacetate

Bifunctional linker containing dibenzocyclooctyne (DBCO, ADIBO) for strain-promoted copper-free click reaction (SPAAC) and free amine for the coupling with various electrophilic compounds like activated esters and epoxides.
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Cat. # Quantity Price Lead time
1280-100mg 100 mg $240 in stock
1280-500mg 500 mg $600 in stock
1280-1g 1 g $1200 in stock
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DBCO NHS ester

Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
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Cat. # Quantity Price Lead time
34720 10 mg $80 in stock
44720 25 mg $110 in stock
54720 50 mg $135 in stock
64720 100 mg $210 in stock
94720 1 g $1000 in stock
K4720 5 g $3570 in stock
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DBCO STP ester

Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.
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Cat. # Quantity Price Lead time
2584-10mg 10 mg $90 in stock
2584-25mg 25 mg $180 in stock
2584-100mg 100 mg $450 in stock
2584-500mg 500 mg $1700 in stock
2584-1g 1 g $3000 in stock
2584-5g 5 g please inquire in stock
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DBCO-PEG6-NHS ester

A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
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Cat. # Quantity Price Lead time
3664-50mg 50 mg $247 in stock
3664-100mg 100 mg $449 in stock
3664-1g 1 g $3490 5 days
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Disuccinimidyl glutarate (DSG)

Homobifunctional crosslinker with two NHS ester groups at each end of a short 5-atom (7.7 angstrom) spacer.
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Cat. # Quantity Price Lead time
4018-100mg 100 mg $95 in stock
4018-1g 1 g $410 in stock
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Hexynoic acid NHS ester

Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.
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Cat. # Quantity Price Lead time
41720 25 mg $95 in stock
51720 50 mg $180 in stock
61720 100 mg $290 in stock
91720 1 g please inquire in stock
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Hexynoic acid STP ester

Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
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569-25mg 25 mg $95 in stock
569-100mg 100 mg $185 in stock
569-500mg 500 mg $850 in stock
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Hydroxy-PEG2-thiol

Short bifunctional linker with thiol and hydroxyl groups. Thiol can coat gold surfaces forming a hydrophilic monolayer.
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Cat. # Quantity Price Lead time
2389-100mg 100 mg $90 in stock
2389-1g 1 g $270 in stock
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Hydroxy-PEG3-thiol

PEG3 bifunctional linker with thiol and hydroxyl groups. Thiol can coat gold surfaces forming a hydrophilic monolayer.
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2368-100mg 100 mg $110 in stock
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Iodo-PEG3-carboxylic acid

A bifunctional compound containing carboxylic acid functional group, and iodide, an active halogen group.
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2063-1g 1 g $190 in stock
2063-5g 5 g $795 in stock
2063-10g 10 g please inquire in stock
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Iodo-PEG3-iodide

Homobifunctional PEG3 based linker with halogen reactive groups is useful for the crosslinking of nucleophiles.
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2098-1g 1 g $290 in stock
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PEG3-dicarboxylic acid

PEG3-dicarboxylic acid is a bifunctional linker carrying two carboxy groups. It contains a polyethyleneglycol-3 linker between the carboxyls.
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Cat. # Quantity Price Lead time
1715-1g 1 g $490 in stock
1715-5g 5 g $890 in stock
1715-10g 10 g $1370 in stock
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PEG3-tetrazine

PEG3 tetrazine is a mono-reactive triethyleneglycol with a tetrazine group for IEDDA conjugation with strained olefins.
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1978-250mg 250 mg $390 in stock
1978-1g 1 g $950 in stock
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Pentynoic acid STP ester

An activated ester for the introduction of alkyne into peptides/proteins and click reaction.
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Cat. # Quantity Price Lead time
30720 10 mg $110 in stock
40720 25 mg $210 in stock
50720 50 mg $410 in stock
60720 100 mg $595 5 days
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sulfo-Cyanine7 bis-NHS ester

sulfo-Cyanine7 bis-NHS ester is a bifunctional derivative of water-soluble near-infrared sulfo-Cyanine7. It contains two activated ester functional groups.
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Cat. # Quantity Price Lead time
153D0 1 mg $125 in stock
253D0 5 mg $325 in stock
453D0 25 mg $850 in stock
553D0 50 mg $1490 in stock
653D0 100 mg $1990 in stock
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Tetraglycine hydrochloride

Tetraglycine is an oligopeptide composed of four glycine monomers. It is used as a bifunctional linker with amino and carboxyl groups.
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3049-500mg 500 mg $319 in stock
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Thalidomide-carboxylic acid

Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.
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Cat. # Quantity Price Lead time
4169-100mg 100 mg $160 in stock
4169-500mg 500 mg $510 in stock
4169-1g 1 g $740 in stock
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Thalidomide-O-PEG2-azide

Thalidomide-containing building block with PEG2-linker and azide function group for conjugation with alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
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Cat. # Quantity Price Lead time
4154-25mg 25 mg $189 in stock
4154-100mg 100 mg $489 in stock
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Thalidomide-O-PEG2-carboxylic acid

Thalidomide-containing building block with PEG2-linker and carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.
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Cat. # Quantity Price Lead time
4192-25mg 25 mg $148 in stock
4192-100mg 100 mg $480 in stock
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