TCO-PEG4-NHS ester (axial isomer)
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3056-10mg | 10 mg | $145 | in stock | |
| 3056-25mg | 25 mg | $225 | in stock | |
| 3056-100mg | 100 mg |
$550
|
in stock |
TCO-PEG4-NHS ester is a bifunctional linker with trans-cyclooctene (TCO) and NHS ester groups flanking PEG4 (tetraethylene glycol).
The PEG spacer increases solubility in aqueous media and provides a long and flexible connection that minimizes steric hindrance involved with ligation.
The amine-reactive N-hydroxysuccinimide residue provides easy attachment to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.
Trans-cyclooctene readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.
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| Appearance: | colorless syrup |
| Molecular weight: | 514.57 |
| CAS number: | 1621096-79-4 |
| Molecular formula: | C24H38N2O10 |
| Solubility: | DMSO, DMF, THF, Acetonitrile, Dichloromethane |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
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