Alkynes in Reactive groups

Terminal alkynes react with azides in a copper-catalyzed process called copper-catalyzed alkyne azide cycloaddition (CuAAC). The reaction is a useful method for the conjugation and fluorescent labeling of biomolecules.

Click chemistry (CuAAc) reaction scheme

Lumiprobe offers a range of terminal alkyne derivatives, including fluorescent dye alkynes, and linkers with alkyne group.

1-Ethynyl pyrene

Pyrene is a polyaromatic hydrocarbon containing four fused rings. This reagent contains a terminal alkyne group for click chemistry and other reactions, such as Sonogashira coupling.
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Cat. # Quantity Price Lead time
515B0 50 mg $50 in stock
615B0 100 mg $64 in stock
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3-Ethynylperylene

Alkyne derivative of ultra-bright and photostable perylene fluorophore.
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Cat. # Quantity Price Lead time
555B0 50 mg $100 in stock
655B0 100 mg $160 in stock
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Ac4GalNAl (N-(4-pentynoyl)-galactosamine-tetraacylated)

An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
4037-5mg 5 mg $129 in stock
4037-25mg 25 mg $240 in stock
4037-100mg 100 mg $630 in stock
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Ac4GlcNAl (N-4-pentynoyl-glucosamine-tetraacylated)

An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
4130-5mg 5 mg $129 in stock
4130-25mg 25 mg $240 in stock
4130-100mg 100 mg $630 in stock
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Ac4ManNAl (N-(4-pentynoyl)-mannosamine-tetraacylated)

An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
3431-5mg 5 mg $129 in stock
3431-25mg 25 mg $240 in stock
3431-100mg 100 mg $630 in stock
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AF 430 alkyne

Alkyne derivative of yellow-green fluorescent dye AF 430 for copper-catalyzed click reaction with azides.
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Cat. # Quantity Price Lead time
A08B0 1 mg $125 in stock
B08B0 5 mg $325 in stock
C08B0 10 mg $480 in stock
D08B0 25 mg $950 in stock
E08B0 50 mg $1625 in stock
F08B0 100 mg $2090 in stock
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AF 488 alkyne

Alkyne derivative of AF 488 dye for copper-catalyzed cycloaddition to azides. Pure 5-isomer.
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Cat. # Quantity Price Lead time
A18B0 1 mg $125 in stock
B18B0 5 mg $325 in stock
D18B0 25 mg $950 in stock
E18B0 50 mg $1625 in stock
F18B0 100 mg $2090 in stock
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AF 568 alkyne

AF 568 derivative designed for fluorescence microscopy and flow cytometry. Pure 5-isomer.
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Cat. # Quantity Price Lead time
A48B0 1 mg $140 in stock
B48B0 5 mg $450 in stock
C48B0 10 mg $585 in stock
D48B0 25 mg $1460 in stock
E48B0 50 mg $1890 in stock
F48B0 100 mg $2990 in stock
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Alkyne amidite, hydroxyprolinol

Acetylenic amidite for the incorporation of acetylene groups into oligos.
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Cat. # Quantity Price Lead time
21360 250 mg $110 in stock
41360 1 g $390 in stock
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Alkyne CPG modifier 500

Solid support for the synthesis of 3'-modified oligonucleotides with alkyne group for Click Chemistry.
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Cat. # Quantity Price Lead time
12860 100 mg $60 in stock
22860 250 mg $120 in stock
32860 500 mg $230 in stock
42860 1 g $380 in stock
52860 5 g $1450 in stock
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Alkyne dT phosphoramidite

Phosphoramidite modifier for the synthesis of oligonucleotides containing alkyne modification in the middle of the chain.
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Cat. # Quantity Price Lead time
1897-100mg 100 mg $330 $195 in stock
1897-1g 1 g $2590 $1250 5 days
1897-5g 5 g $9900 $2850 in stock
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Alkyne hydrazide

Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
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Cat. # Quantity Price Lead time
41770 25 mg $110 in stock
51770 50 mg $195 in stock
61770 100 mg $290 in stock
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Alkyne maleimide

Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
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Cat. # Quantity Price Lead time
41780 25 mg $95 in stock
51780 50 mg $175 in stock
61780 100 mg $200 in stock
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Alkyne phosphoramidite, 5'-terminal

Alkyne phosphoramidite for the synthesis of oligonucleotides ready for click chemistry.
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Cat. # Quantity Price Lead time
22260 250 mg $110 in stock
32260 500 mg $210 in stock
42260 1 g $350 in stock
62260 5 g $1290 in stock
82260 10 g please inquire in stock
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Alkyne-PEG2-amine

Diethyleneglycol (PEG2) based bifunctional linker containing amine and alkyne functional groups.
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Cat. # Quantity Price Lead time
2065-1g 1 g $120 in stock
2065-5g 5 g $350 in stock
2065-25g 25 g please inquire in stock
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Alkyne-PEG2-carboxylic acid

Bifunctional diethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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Cat. # Quantity Price Lead time
2155-1g 1 g $380 in stock
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Alkyne-PEG2-iodide

Bifunctional reactive crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling, and reactive alkyl iodide group.
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Cat. # Quantity Price Lead time
2136-1g 1 g $450 in stock
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Alkyne-PEG2-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
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Cat. # Quantity Price Lead time
2219-1g 1 g $450 in stock
2219-5g 5 g $980 in stock
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Alkyne-PEG3-amine

Alkyne-PEG3-amine is a medium-length heterobifunctional linker for conjugation.
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Cat. # Quantity Price Lead time
425-1g 1 g $195 in stock
425-5g 5 g $580 in stock
425-25g 25 g please inquire in stock
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Alkyne-PEG3-carboxylic acid

Bifunctional triethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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Cat. # Quantity Price Lead time
1743-1g 1 g $490 in stock
1743-5g 5 g $980 in stock
1743-25g 25 g please inquire in stock
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Alkyne-PEG3-iodide

PEG3 with alkyne and iodide functional groups, a reactive and hydrophilic linker for alkylation and click chemistry.
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Cat. # Quantity Price Lead time
2193-1g 1 g $490 in stock
2193-5g 5 g $1150 in stock
2193-25g 25 g please inquire in stock
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Alkyne-PEG3-maleimide

Bifunctional spacer with alkyne and maleimide groups for conjugation of biomolecules.
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Cat. # Quantity Price Lead time
2344-100mg 100 mg $140 in stock
2344-1g 1 g $530 in stock
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Alkyne-PEG3-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
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Cat. # Quantity Price Lead time
2298-1g 1 g $490 in stock
2298-5g 5 g $980 in stock
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Alkyne-PEG3-OH

Alkyne-PEG3-OH is a triethyleneglycol based bifunctional linker with a hydroxyl group and an alkyne fragment.
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Cat. # Quantity Price Lead time
418-1g 1 g $95 in stock
418-5g 5 g $280 in stock
418-25g 25 g please inquire in stock
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Alkyne-PEG4-amine

A bifunctional linker molecule containing both terminal alkyne moiety for click chemistry, and amine group. Contains a long hydrophilic PEG4 arm.
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Cat. # Quantity Price Lead time
2025-100mg 100 mg $95 in stock
2025-1g 1 g $390 in stock
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Alkyne-PEG4-carboxylic acid

Bifunctional tetraethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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Cat. # Quantity Price Lead time
2187-1g 1 g $380 in stock
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Alkyne-PEG4-iodide

Bifunctional reactive PEG4-based crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling and reactive alkyl iodide group.
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Cat. # Quantity Price Lead time
2188-1g 1 g $450 in stock
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Alkyne-PEG4-maleimide

Water soluble, heterobifunctional hydrophilic linker with a length of 14 Å, containing maleimide for thiol labeling, and alkyne for click chemistry. An ideal reagent to attach an alkyne moiety to a protein.
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Cat. # Quantity Price Lead time
2002-100mg 100 mg $150 in stock
2002-1g 1 g $590 in stock
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Alkyne-PEG4-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
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Cat. # Quantity Price Lead time
2409-100mg 100 mg $250 in stock
2409-1g 1 g $790 in stock
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Alkyne-PEG4-phosphoramidite

Alkyne phosphoramidite for conjugation of oligonucleotides with biomolecules.
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Cat. # Quantity Price Lead time
2779-100mg 100 mg $390 in stock
2779-250mg 250 mg $680 in stock
2779-1g 1 g $1640 in stock
2779-5g 5 g please inquire in stock
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BDP 558/568 alkyne

BDP 558/568 is a borondipyrromethene dye for Cyanine3-channel. This product is a terminal alkyne derivative for copper-catalyzed click chemistry.
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Cat. # Quantity Price Lead time
A74B0 1 mg $125 in stock
B74B0 5 mg $260 in stock
C74B0 10 mg $325 in stock
D74B0 25 mg $510 in stock
E74B0 50 mg $895 in stock
F74B0 100 mg $1490 in stock
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BDP 581/591 alkyne

BDP 581/591 is a borondipyrromethene fluorophore useful for fluorescence polarization assays, microscopy, and two-photon experiments. This alkyne is a derivative for copper-catalyzed click chemistry.
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Cat. # Quantity Price Lead time
A64B0 1 mg $125 in stock
B64B0 5 mg $260 in stock
C64B0 10 mg $325 in stock
D64B0 25 mg $510 in stock
E64B0 50 mg $895 in stock
F64B0 100 mg $1490 in stock
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BDP 630/650 alkyne

Alkyne dye for copper-catalyzed click chemistry, containing borondipyrromethene fluorophore BDP 630/650 for the red channel.
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Cat. # Quantity Price Lead time
A54B0 1 mg $125 in stock
B54B0 5 mg $260 in stock
C54B0 10 mg $325 in stock
D54B0 25 mg $510 in stock
E54B0 50 mg $895 in stock
F54B0 100 mg $1490 in stock
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BDP 650/665 alkyne

BDP 650/665 is a bright borondipyrromethene red-emitting dye. The terminal ethynyl group of BDP 650/665 alkyne can be easily conjugated with various azides using a copper-catalyzed click reaction.
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Cat. # Quantity Price Lead time
A84B0 1 mg $125 in stock
B84B0 5 mg $260 in stock
C84B0 10 mg $325 in stock
D84B0 25 mg $510 in stock
E84B0 50 mg $895 in stock
F84B0 100 mg $1490 in stock