Alkyne dT phosphoramidite

Oligonucleotide synthesis Alkynes Phosphoramidites Click chemistry

Cat. #	Quantity	Price	Lead time
1897-100mg	100 mg	$330 $195	in stock
1897-1g	1 g	$2590 $1250	in stock
1897-5g	5 g	$9900 $2850	in stock

Found better price? Let us know and we will propose the way forward!

This reagent is designed for the synthesis of oligonucleotides bearing triple bond (alkyne) in the middle of the chain. Alkyne is attached to the deoxyuridine fragment, and it does not interfere with the hybridization of the complementary strand. This allows the preparation of modified oligonucleotide probes bearing fluorescent dyes, quenchers, and other fragments attached to the middle of the chain by virtue of copper-catalyzed Click chemistry reaction with various azides.

This phosphoramidite is solid, so it is easy to dispense and handle. It is compatible with the standard deblocking conditions.

Download in
ChemDraw format

Customers also purchased with this product

THPTA ligand

THPTA is a water-soluble ligand for Cu(I)-catalyzed click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.

HEX azide, 6-isomer

Azide of green-yellow emitting HEX dye for conjugation with oligonucleotides via [3+2]-dipolar cycloaddition.

DusQ® 2 CPG 500

Controlled pore glass (CPG) 500 modified support for the synthesis of oligonucleotides with DusQ® 2 quencher at the 3′ end. Compatible with standard deblocking conditions.

Add this product to your cart and
get free express delivery

General properties

Appearance:	off white solid
Mass spec M+ increment:	437.1
Molecular weight:	877.96
Molecular formula:	C₄₈H₅₆N₅O₉P
Solubility:	good in acetonitrile, DCM
Quality control:	NMR ¹H, NMR ³¹P, HPLC-MS
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

Oligo synthesis details

Diluent:	acetonitrile
Coupling conditions:	standard coupling, identical to normal nucleobases
Cleavage conditions:	ammonia, 2 h at room temperature
Deprotection conditions:	identical to protected nucleobases

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.