PROTAC in Applications

Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

Thalidomide-carboxylic acid

Thalidomide containing building block with carboxylic acid functionality for convenient PROTAC molecules assembly by attachment via 4-O-position thalidomide of amino-fictionalized linkers and ligands.
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Cat. # Quantity Price Lead time
4169-100mg 100 mg $160.00 in stock
4169-500mg 500 mg $510.00 in stock
4169-1g 1 g $740.00 in stock

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