Cycloalkynes in Reactive groups
Strained cycloalkynes, like cyclooctynes, react quickly with azides in a reaction called SPAAC, strain-promoted alkyne-azide cycloaddition. The reaction does not require catalyst, it is very rapid and high yielding. The process is useful for the conjugation of different classes of molecules even in vivo.
There is a balance between reactivity and stability of cycloalkynes. Azodibenzocyclooctynes (DBCO, ADIBO) are cyclooctyne derivatives that are characterized by excellent reaction kinetics and very good stability.
AF 488 DBCO
Dibenzocyclooctyne (DBCO, ADIBO) containing the green fluorophore AF 488 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples. Pure 5-isomer.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 118F0 | 1 mg | $140 | in stock | |
| 218F0 | 5 mg |
$450
|
in stock | |
| 418F0 | 25 mg |
$1460
|
in stock | |
| 518F0 | 50 mg |
$1890
|
in stock | |
| 618F0 | 100 mg |
$2640
|
in stock |
AF 555 DBCO
Dibenzocyclooctyne (DBCO, ADIBO) containing the yellow fluorophore AF 555 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1K8F0 | 1 mg | $140 | in stock | |
| 2K8F0 | 5 mg |
$450
|
in stock | |
| 4K8F0 | 25 mg |
$1460
|
in stock | |
| 5K8F0 | 50 mg |
$1890
|
in stock | |
| 6K8F0 | 100 mg |
$2990
|
in stock |
AF 568 DBCO
Dibenzocyclooctyne (DBCO, ADIBO) containing the orange fluorophore AF 568 for cooper-free labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1158F0 | 1 mg | $140 | in stock | |
| 2158F0 | 5 mg |
$450
|
in stock | |
| 4158F0 | 25 mg |
$1460
|
in stock | |
| 5158F0 | 50 mg |
$1890
|
in stock | |
| 6158F0 | 100 mg |
$2990
|
in stock |
AF 647 DBCO
Dibenzocyclooctyne (DBCO, ADIBO) derivative of the far red fluorophore AF 647 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1G8F0 | 1 mg | $140 | in stock | |
| 2G8F0 | 5 mg |
$450
|
in stock | |
| 4G8F0 | 25 mg |
$1460
|
in stock | |
| 5G8F0 | 50 mg |
$1890
|
in stock | |
| 6G8F0 | 100 mg |
$2990
|
in stock |
BDP® 558/568 DBCO
BDP 558/568 DBCO is a bright and photostable dye with emission in the yellow spectrum range. It contains a cyclooctyne substituting group (i.e. DBCO), which can react with various azides in Click Chemistry reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 174F0 | 1 mg | $125 | in stock | |
| 274F0 | 5 mg | $260 | in stock | |
| 374F0 | 10 mg | $325 | in stock | |
| 474F0 | 25 mg |
$510
|
in stock | |
| 574F0 | 50 mg |
$895
|
in stock | |
| 674F0 | 100 mg |
$1490
|
in stock |
BDP® 581/591 DBCO
BDP 581/591 is a borondipyrromethene dye that can be used not only as a fluorescent dye, but also as a ROS probe. It can be conjugated with azides using copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A64F0 | 1 mg | $125 | in stock | |
| B64F0 | 5 mg | $260 | in stock | |
| C64F0 | 10 mg | $325 | in stock | |
| D64F0 | 25 mg |
$510
|
in stock | |
| E64F0 | 50 mg |
$895
|
in stock | |
| F64F0 | 100 mg |
$1490
|
in stock |
BDP® 650/665 DBCO
This red-fluorescent dye contains a substituting group for copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| AE4F0 | 1 mg | $125 | in stock | |
| BE4F0 | 5 mg | $260 | in stock | |
| CE4F0 | 10 mg | $325 | in stock | |
| DE4F0 | 25 mg |
$510
|
in stock | |
| EE4F0 | 50 mg |
$895
|
in stock | |
| FE4F0 | 100 mg |
$1490
|
in stock |
BDP® FL DBCO
BDP FL DBCO is a dye cyclooctyne for copper-free click chemistry reactions with azides. Its absorption and emission wavelengths correspond to those of fluorescein (FAM), but BDP FL is significantly more photostable.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A14F0 | 1 mg | $125 | in stock | |
| B14F0 | 5 mg | $260 | in stock | |
| C14F0 | 10 mg | $325 | in stock | |
| D14F0 | 25 mg |
$510
|
in stock | |
| E14F0 | 50 mg |
$895
|
in stock | |
| F14F0 | 100 mg |
$1490
|
in stock |
BDP® R6G DBCO
A derivative of BDP R6G dye with azodibenzocyclooctyne (DBCO or ADIBO) for copper-free click chemistry conjugation with azides.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A44F0 | 1 mg | $125 | in stock | |
| B44F0 | 5 mg | $260 | in stock | |
| C44F0 | 10 mg | $325 | in stock | |
| D44F0 | 25 mg |
$510
|
in stock | |
| E44F0 | 50 mg |
$895
|
in stock | |
| F44F0 | 100 mg |
$1490
|
in stock |
BDP® TMR DBCO
This yellow-orange-fluorescent boron dipyrromethene dye contains a DBCO substituting group for participation in click chemistry reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 124F0 | 1 mg | $125 | in stock | |
| 224F0 | 5 mg | $260 | in stock | |
| 424F0 | 25 mg |
$510
|
in stock | |
| 524F0 | 50 mg |
$895
|
in stock | |
| 624F0 | 100 mg |
$1490
|
in stock |
BDP® TR DBCO
A dye with a dibenzocyclooctyne substituting group for the ROX channel.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1D4F0 | 1 mg | $125 | in stock | |
| 2D4F0 | 5 mg | $260 | in stock | |
| 4D4F0 | 25 mg |
$510
|
in stock | |
| 5D4F0 | 50 mg |
$895
|
in stock | |
| 6D4F0 | 100 mg |
$1490
|
in stock |
Cyanine3 DBCO
Cyanine3 dibenzocyclooctyne (DBCO, or ADIBO) is a cycloalkyne dye derivative for copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A10F0 | 1 mg | $125 | in stock | |
| B10F0 | 5 mg | $260 | in stock | |
| C10F0 | 10 mg | $325 | in stock | |
| D10F0 | 25 mg |
$510
|
in stock | |
| E10F0 | 50 mg |
$895
|
in stock | |
| F10F0 | 100 mg |
$1490
|
in stock |
Cyanine3-PEG4-BCN (exo)
Cyanine3-PEG4-BCN is an ethylene glycol separated linker for the azido-modified molecules for copper-free click conjugation.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| NO items of this product available in stock but you can submit request for bulk. | ||||
Cyanine3.5 DBCO
Cyclooctyne derivative of Cyanine3.5 dye, which easily reacts with various azides resulting in stable conjugates.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A20F0 | 1 mg | $125 | in stock | |
| B20F0 | 5 mg | $260 | in stock | |
| C20F0 | 10 mg | $325 | in stock | |
| D20F0 | 25 mg |
$510
|
in stock | |
| E20F0 | 50 mg |
$895
|
in stock | |
| F20F0 | 100 mg |
$1490
|
in stock |
Cyanine3B DBCO
Dibenzocyclooctyne (DBCO, ADIBO) containing Cyanine3B fluorophore for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 193F0 | 1 mg | $369 | in stock | |
| 293F0 | 5 mg |
$727
|
in stock | |
| 493F0 | 25 mg |
$1950
|
in stock |
Cyanine5 DBCO
Cyanine5 dye with dibenzocyclooctyne (DBCO) functional group for copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A30F0 | 1 mg | $125 | in stock | |
| B30F0 | 5 mg | $260 | in stock | |
| C30F0 | 10 mg | $325 | in stock | |
| D30F0 | 25 mg |
$510
|
in stock | |
| E30F0 | 50 mg |
$895
|
in stock | |
| F30F0 | 100 mg |
$1490
|
in stock |
Cyanine5.5 DBCO
Cyanine5.5 is a far-red / NIR emitting dye that is useful for bioimaging studies. Cyanine5.5 DBCO is a derivative of the dye with a cycloalkyne moiety for copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A70F0 | 1 mg | $125 | in stock | |
| B70F0 | 5 mg | $260 | in stock | |
| C70F0 | 10 mg | $325 | in stock | |
| D70F0 | 25 mg |
$510
|
in stock | |
| E70F0 | 50 mg |
$895
|
in stock | |
| F70F0 | 100 mg |
$1490
|
in stock |