Cycloalkynes in Reactive groups

Strained cycloalkynes, like cyclooctynes, react quickly with azides in a reaction called SPAAC, strain-promoted alkyne-azide cycloaddition. The reaction does not require catalyst, it is very rapid and high yielding. The process is useful for the conjugation of different classes of molecules even in vivo.

There is a balance between reactivity and stability of cycloalkynes. Azodibenzocyclooctynes (DBCO, ADIBO) are cyclooctyne derivatives that are characterized by excellent reaction kinetics and very good stability.

AF 488 DBCO

Dibenzocyclooctyne (DBCO, ADIBO) containing the green fluorophore AF 488 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples. Pure 5-isomer.
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Cat. # Quantity Price Lead time
118F0 1 mg $140 in stock
218F0 5 mg $450 in stock
418F0 25 mg $1460 in stock
518F0 50 mg $1890 in stock
618F0 100 mg $2640 in stock
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AF 568 DBCO

Dibenzocyclooctyne (DBCO, ADIBO) containing the orange fluorophore AF 568 for cooper-free labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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Cat. # Quantity Price Lead time
1158F0 1 mg $140 in stock
2158F0 5 mg $450 in stock
4158F0 25 mg $1460 in stock
5158F0 50 mg $1890 in stock
6158F0 100 mg $2990 in stock
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BCN-PEG4-Cyanine3 (exo)

BCN-PEG4-Cyanine3 is an ethylene glycol separated linker for the azido-modified molecules for copper-free click conjugation.
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Cat. # Quantity Price Lead time
3269-1mg 1 mg $105 21 days
3269-5mg 5 mg $295 in stock
3269-50mg 50 mg $2500 in stock
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BDP 558/568 DBCO

BDP 558/568 DBCO is a bright and photostable dye with emission in the yellow spectrum range. It contains a cyclooctyne substituting group (i.e. DBCO), which can react with various azides in Click Chemistry reactions.
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Cat. # Quantity Price Lead time
174F0 1 mg $125 in stock
274F0 5 mg $260 in stock
374F0 10 mg $325 in stock
474F0 25 mg $510 in stock
574F0 50 mg $895 in stock
674F0 100 mg $1490 in stock
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BDP 581/591 DBCO

BDP 581/591 is a borondipyrromethene dye that can be used not only as a fluorescent dye, but also as a ROS probe. It can be conjugated with azides using copper-free click chemistry.
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Cat. # Quantity Price Lead time
A64F0 1 mg $125 in stock
B64F0 5 mg $260 in stock
C64F0 10 mg $325 in stock
D64F0 25 mg $510 in stock
E64F0 50 mg $895 in stock
F64F0 100 mg $1490 in stock
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BDP 650/665 DBCO

This red-fluorescent dye contains a substituting group for copper-free click chemistry.
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Cat. # Quantity Price Lead time
AE4F0 1 mg $125 in stock
BE4F0 5 mg $260 in stock
CE4F0 10 mg $325 in stock
DE4F0 25 mg $510 in stock
EE4F0 50 mg $895 in stock
FE4F0 100 mg $1490 in stock
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BDP FL DBCO

BDP FL DBCO is a dye cyclooctyne for copper-free click chemistry reaction with azides. Absorption and emission wavelengths of BDP FL correspond to those of fluorescein (FAM), but BDP FL is significantly more photostable.
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Cat. # Quantity Price Lead time
A14F0 1 mg $125 in stock
B14F0 5 mg $260 in stock
C14F0 10 mg $325 in stock
D14F0 25 mg $510 in stock
E14F0 50 mg $895 in stock
F14F0 100 mg $1490 in stock
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BDP R6G DBCO

A derivative of BDP R6G dye with azodibenzocyclooctyne (DBCO or ADIBO) for copper-free click chemistry conjugation with azides.
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Cat. # Quantity Price Lead time
A44F0 1 mg $125 in stock
B44F0 5 mg $260 in stock
C44F0 10 mg $325 in stock
D44F0 25 mg $510 in stock
E44F0 50 mg $895 in stock
F44F0 100 mg $1490 in stock
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BDP TMR DBCO

This yellow-orange-fluorescent boron dipyrromethene dye contains a DBCO substituting group for participation in click chemistry reactions.
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Cat. # Quantity Price Lead time
124F0 1 mg $125 in stock
224F0 5 mg $260 in stock
424F0 25 mg $510 in stock
524F0 50 mg $895 in stock
624F0 100 mg $1490 in stock
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BDP TR DBCO

A dye with a dibenzocyclooctyne substituting group for the ROX channel.
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Cat. # Quantity Price Lead time
1D4F0 1 mg $125 in stock
2D4F0 5 mg $260 in stock
4D4F0 25 mg $510 in stock
5D4F0 50 mg $895 in stock
6D4F0 100 mg $1490 in stock
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Cyanine3 DBCO

Cyanine3 dibenzocyclooctyne (DBCO, or ADIBO) is a cycloalkyne dye derivative for copper-free click chemistry.
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Cat. # Quantity Price Lead time
A10F0 1 mg $125 in stock
B10F0 5 mg $260 in stock
C10F0 10 mg $325 in stock
D10F0 25 mg $510 in stock
E10F0 50 mg $895 in stock
F10F0 100 mg $1490 in stock
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Cyanine3.5 DBCO

Cyclooctyne derivative of Cyanine3.5 dye, which easily reacts with various azides resulting in stable conjugates.
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Cat. # Quantity Price Lead time
A20F0 1 mg $125 in stock
B20F0 5 mg $260 in stock
C20F0 10 mg $325 in stock
D20F0 25 mg $510 in stock
E20F0 50 mg $895 in stock
F20F0 100 mg $1490 in stock
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Cyanine3B DBCO

Dibenzocyclooctyne (DBCO, ADIBO) containing Cyanine3B fluorophore for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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Cat. # Quantity Price Lead time
193F0 1 mg $369 21 days
293F0 5 mg $627 21 days
493F0 25 mg please inquire 21 days
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Cyanine5 DBCO

Cyanine5 dye with dibenzocyclooctyne (DBCO) functional group for copper-free click chemistry.
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Cat. # Quantity Price Lead time
A30F0 1 mg $125 in stock
B30F0 5 mg $260 in stock
C30F0 10 mg $325 in stock
D30F0 25 mg $510 in stock
E30F0 50 mg $895 in stock
F30F0 100 mg $1490 in stock
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Cyanine5.5 DBCO

Cyanine5.5 is a far-red / NIR emitting dye that is useful for bioimaging studies. Cyanine5.5 DBCO is a derivative of the dye with a cycloalkyne moiety for copper-free click chemistry.
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Cat. # Quantity Price Lead time
A70F0 1 mg $125 in stock
B70F0 5 mg $260 in stock
C70F0 10 mg $325 in stock
D70F0 25 mg $510 in stock
E70F0 50 mg $895 in stock
F70F0 100 mg $1490 in stock
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Cyanine7 DBCO

NIR fluorescent dye functionalized with cyclooctyne moiety for copper free click chemistry conjugation with azides.
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Cat. # Quantity Price Lead time
A50F0 1 mg $125 in stock
B50F0 5 mg $260 in stock
C50F0 10 mg $325 in stock
D50F0 25 mg $510 in stock
E50F0 50 mg $895 in stock
F50F0 100 mg $1490 in stock
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DBCO amine trifluoroacetate

Bifunctional linker containing dibenzocyclooctyne (DBCO, ADIBO) for strain-promoted copper-free click reaction (SPAAC) and free amine for the coupling with various electrophilic compounds like activated esters and epoxides.
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Cat. # Quantity Price Lead time
1280-100mg 100 mg $240 in stock
1280-500mg 500 mg $600 in stock
1280-1g 1 g $1200 in stock
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DBCO NHS ester

Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
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Cat. # Quantity Price Lead time
34720 10 mg $80 in stock
44720 25 mg $110 in stock
54720 50 mg $135 in stock
64720 100 mg $210 in stock
94720 1 g $1000 in stock
K4720 5 g $3570 in stock
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DBCO STP ester

Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.
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Cat. # Quantity Price Lead time
2584-10mg 10 mg $90 in stock
2584-25mg 25 mg $180 in stock
2584-100mg 100 mg $450 in stock
2584-500mg 500 mg $1700 in stock
2584-1g 1 g $3000 in stock
2584-5g 5 g please inquire 21 days
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DBCO-PEG6-NHS ester

A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
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Cat. # Quantity Price Lead time
3664-50mg 50 mg $247 in stock
3664-100mg 100 mg $449 in stock
3664-1g 1 g $3490 5 days
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endo-BCN CE-phosphoramidite

BCN-containing phosphoramidite for the synthesis of oligonucleotides and their labeling using copper-free click reactions.
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Cat. # Quantity Price Lead time
3005-100mg 100 mg $390 in stock
3005-250mg 250 mg $800 in stock
3005-1g 1 g $2350 in stock
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Exo-BCN-PNP

BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.
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Cat. # Quantity Price Lead time
4043-100mg 100 mg $280 in stock
4043-500mg 500 mg $990 in stock
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FAM DBCO, 6-isomer

Cyclooctyne derivative of fluorescein (FAM) for copper-free click chemistry reaction with azides. Pure 6-isomer of fluorescein.
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Cat. # Quantity Price Lead time
151F0 1 mg $110 in stock
251F0 5 mg $160 in stock
451F0 25 mg $260 in stock
551F0 50 mg $370 in stock
651F0 100 mg $525 in stock
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ROX DBCO, 5-isomer

ROX (rhodamine X) is a bright rhodamine dye. This is a DBCO (dibenzocyclooctyne) derivative that has high reactivity against azides.
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Cat. # Quantity Price Lead time
112F0 1 mg $110 in stock
212F0 5 mg $210 in stock
412F0 25 mg $410 in stock
512F0 50 mg $695 in stock
612F0 100 mg $1190 in stock
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sulfo-Cyanine3 DBCO

sulfo-Cyanine3 DBCO is a cycloalkyne derivative of water-soluble fluorophore sulfo-Cyanine3 for copper-free click chemistry.
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Cat. # Quantity Price Lead time
113F0 1 mg $125 in stock
213F0 5 mg $325 in stock
413F0 25 mg $850 in stock
513F0 50 mg $1490 in stock
613F0 100 mg $1990 in stock
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sulfo-Cyanine5 DBCO

Water soluble cycloalkyne for copper-free click chemistry reaction with azides. A derivative of sulfo-Cyanine5.
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Cat. # Quantity Price Lead time
133F0 1 mg $125 in stock
233F0 5 mg $325 in stock
433F0 25 mg $850 in stock
533F0 50 mg $1490 in stock
633F0 100 mg $1990 in stock
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sulfo-Cyanine5.5 DBCO

Sulfo-Cyanine5.5 DBCO is a far-red, water-soluble reagent for copper-free click reaction with azides.
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Cat. # Quantity Price Lead time
173F0 1 mg $125 in stock
273F0 5 mg $325 in stock
473F0 25 mg $850 in stock
573F0 50 mg $1490 in stock
673F0 100 mg $1990 in stock
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sulfo-Cyanine7 DBCO

Dibenzocyclooctyne (DBCO, or ADIBO) conjugated with sulfo-Cyanine7, a water-soluble near-IR dye for labeling azide-containing biomolecules inside living cells, whole organisms, and inanimate samples.
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Cat. # Quantity Price Lead time
153F0 1 mg $125 in stock
253F0 5 mg $325 in stock
453F0 25 mg $850 in stock
553F0 50 mg $1490 in stock
653F0 100 mg $1990 in stock
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TAMRA DBCO, 5-isomer

Cyclooctyne derivative of tetramethylrhodamine (TMR, TAMRA) for copper-free click chemistry conjugation with azides. Pure 5-isomer.
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Cat. # Quantity Price Lead time
171F0 1 mg $125 in stock
271F0 5 mg $395 in stock
471F0 25 mg $890 in stock
571F0 50 mg $1490 in stock
671F0 100 mg $1990 in stock
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