Cyanine5 DBCO

Cat. # Quantity Price Lead time
A30F0 1 mg $110.00 in stock
B30F0 5 mg $210.00 in stock
C30F0 10 mg $310.00 in stock
D30F0 25 mg $410.00 in stock
E30F0 50 mg $695.00 in stock
F30F0 100 mg $1190.00 in stock

A derivative of Cyanine5 red-emitting fluorophore possessing DBCO (dibenzocyclooctyne, also known as ADIBO, azodibenzocyclooctyne) group for copper free Click chemistry.

Strained cycloalkynes, such as cyclooctynes, react with azides very rapidly in the absence of copper catalyst in a strain promoted alkyne azide cycloaddition (spAAC). This reaction is very fast, mild, and biocompatible.

Compared to other cycloalkynes, DBCO provide among the fastest reaction kinetics, still possessing good stability.

Absorption and emission spectra of Cyanine5

Absorption and emission spectra of Cyanine5

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Cyanine5.5 tetrazine

A compound containing Cyanine5.5 fluorophore, a far red emitting dye, and tetrazine fragment for the conjugation with trans-cyclooctenes / cyclopropenes via TCO ligation.

Cyanine5.5 NHS ester

Cyanine5.5 NHS is far-red / near-infrared amine-reactive dye.
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Cyanine3 amine

Cyanine3 is an fluorophore with free amino group (amino-dye). It can be conjugated with NHS esters, carboxy groups (after activation), and epoxides.

General properties

Appearance: dark blue solid
Mass spec M+ increment: 928.4
Molecular weight: 929.03
Molecular formula: C53H59N4F6O2P
Solubility: good in DMF, DMSO, chlorinated organic solvents, practically insoluble in water (<1 uM, < 1 mg/L)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 646
ε, L⋅mol−1⋅cm−1: 250000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.2
CF260: 0.03
CF280: 0.04

Product citations

  1. Liu, W.; Zhao, W.; Bai, X.; Jin, S.; Li, Y.; Qiu, C.; Pan, L.; Ding, D.; Xu, Y.; Zhou, Z.; Chen, S. High antitumor activity of Sortase A-generated anti-CD20 antibody fragment drug conjugates. European Journal of Pharmaceutical Sciences, 2019, 134, 81–92. doi: 10.1016/j.ejps.2019.04.015
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