Cyanine7.5 NHS ester

Cat. # Quantity Price Lead time
16020 1 mg $110.00 in stock
26020 5 mg $210.00 in stock
46020 25 mg $410.00 in stock
56020 50 mg $695.00 in stock
66020 100 mg $1190.00 in stock

Cyanine7.5 is a NIR dye with very long-wave emission. This product is amine-reactive derivative of this fluorophore.

Near infrared radiation readily penetrates tissues and can be used for imaging applications in vivo.

This product can be used for the labeling of various biomolecules containing amine groups, such as proteins and peptides, to track their distribution in organism in vivo by NIR imaging.

Increased rigidity of central polymethyne moiety allows to increase quantum yield by 20% compared to parent structure of Cy7.5® NHS.

Cy7.5 absorbance and emission spectra

Cy7.5 absorbance and emission spectra

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Sulfo-Cyanine7 amine

Water-soluble NIR dye amine, sulfonated derivative of Cyanine7 dye, for the modification via enzymatical transamination.

General properties

Appearance: green powder
Mass spec M+ increment: 630.4
Molecular weight: 833.76
CAS number: 1469541-54-5 (without anion), 1469278-04-3 (chloride)
Molecular formula: C49H52N3BF4O4
IUPAC name: 1H-​Benz[e]​indolium, 2-​[2-​[3-​[2-​(1,​3-​dihydro-​1,​1,​3-​trimethyl-​2H-​benz[e]​indol-​2-​ylidene)​ethylidene]​-​1-​cyclohexen-​1-​yl]​ethenyl]​-​3-​[6-​[(2,​5-​dioxo-​1-​pyrrolidinyl)​oxy]​-​6-​oxohexyl]​-​1,​1-​dimethyl-
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 788
ε, L⋅mol−1⋅cm−1: 223000
Emission maximum, nm: 808

Product citations

  1. Gonzales, J.; Pirovano, G.; Chow, C.Y.; de Souza Franca, P.D.; Carter, L.M.; Klint, J.K.; Guru, N.; Lewis, J.S.; King, G.F.; Reiner, T. Fluorescence labeling of a Nav1.7-targeted peptide for near-infrared nerve visualization. EJNMMI Research, 2020, 10, 49. doi: 10.1186/s13550-020-00630-4
  2. Zhang, Y.; García-Gabilondo, M.; Grayston, A.; Feiner, I.V.J.; Anton-Sales, I.; Loiola, R.A.; Llop, J.; Ramos-Cabrer, P.; Barba, I:; Garcia-Dorado, D.; Gosselet, F.; Rosell, A.; Roig, A. PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities. Nanoscale, 2020, 12(8), 4988–5002. doi: 10.1039/c9nr10620k
  3. Jiang, S.; Prozeller, D.; Pereira, J.; Simon, J.; Han, S.; Wirsching, S.; Fichter, M.; Mottola, M.; Lieberwirth, I.; Morsbach, S.; Mailänder, V.; Gehring, S.; Crespy, D.; Landfester, K. Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules. Nanoscale, 2020, 12(4), 2626–2637. doi: 10.1039/c9nr09879h
  4. Gui, Z.; Zhu, J.; Ye, S.; Ye, J.; Chen, J.; Ling, Y.; Cai, X.; Cao, P.; He, Z.; Hu, C. Prolonged melittin release from polyelectrolyte-based nanocomplexes decreases acute toxicity and improves blood glycemic control in a mouse model of type II diabetes. International Journal of Pharmaceutics, 2020, 577, 119071. doi: 10.1016/j.ijpharm.2020.119071
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