Cyanine7.5 NHS ester

Cat. # Quantity Price Lead time
16020 1 mg $110.00 in stock
26020 5 mg $210.00 in stock
46020 25 mg $410.00 in stock
56020 50 mg $695.00 in stock
66020 100 mg $1190.00 in stock

Cyanine7.5 is a NIR dye with very long-wave emission. This product is amine-reactive derivative of this fluorophore.

Near infrared radiation readily penetrates tissues and can be used for imaging applications in vivo.

This product can be used for the labeling of various biomolecules containing amine groups, such as proteins and peptides, to track their distribution in organism in vivo by NIR imaging.

Increased rigidity of central polymethyne moiety allows to increase quantum yield by 20% compared to parent structure of Cy7.5® NHS.

Cy7.5 absorbance and emission spectra

Cy7.5 absorbance and emission spectra

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General properties

Appearance: green powder
Mass spec M+ increment: 630.4
Molecular weight: 833.76
CAS number: 1469541-54-5 (without anion), 1469278-04-3 (chloride)
Molecular formula: C49H52N3BF4O4
IUPAC name: 1H-​Benz[e]​indolium, 2-​[2-​[3-​[2-​(1,​3-​dihydro-​1,​1,​3-​trimethyl-​2H-​benz[e]​indol-​2-​ylidene)​ethylidene]​-​1-​cyclohexen-​1-​yl]​ethenyl]​-​3-​[6-​[(2,​5-​dioxo-​1-​pyrrolidinyl)​oxy]​-​6-​oxohexyl]​-​1,​1-​dimethyl-
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 788
ε, L⋅mol−1⋅cm−1: 223000
Emission maximum, nm: 808

Product citations

  1. Näkki, S.; Wang, J.T.-W.; Wu, J.; Fan, L.; Rantanen, J.; Nissinen, T.; Kettunen, M.I.; Backholm, M.; Ras, R.H.A.; Al-Jamal, K.T.; Lehto, V.-P.; Xu, W. Designed inorganic porous nanovector with controlled release and MRI features for safe administration of doxorubicin. International Journal of Pharmaceutics, 2019, 554, 327–336. doi: 10.1016/j.ijpharm.2018.10.074
  2. Xu, H.; Bandari, R.; Lee, L.E.; Li, R.; Yu, P.; Smith, C.J.; Ma, L. Design, Synthesis, and In Vitro and In Vivo Evaluation of High Affinity and Specificity Near-Infrared Fluorescent Bombesin Antagonists for Tumor Imaging. Journal of Medicinal Chemistry, 2018, 61(17), 7657–7670. doi: 10.1021/acs.jmedchem.8b00614
  3. Jones, J.E.; Busi, S.B.; Mitchem, J.B.; Amos-Landgraf, J.M.; Lewis, M.R. Evaluation of a Tumor-Targeting, Near-Infrared Fluorescent Peptide for Early Detection and Endoscopic Resection of Polyps in a Rat Model of Colorectal Cancer. Molecular Imaging, 2018, 17, 1536012118790065. doi: 10.1177/1536012118790065
  4. He, S.; Li, C.; Zhang, Q.; Ding, J.; Liang, X.-J.; Chen, X.; Xiao, H.; Chen, X.; Zhou, D.; Huang, Y. Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine. ACS Nano, 2018, 12(7), 7272–7281. doi: 10.1021/acsnano.8b03476
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