Cyanine7.5 NHS ester

Cyanine7.5 NHS esters Near infrared (NIR) imaging
Cat. # Quantity Price Lead time
16020 1 mg 110.00$ 5 days
26020 5 mg 210.00$ in stock
46020 25 mg 410.00$ in stock
56020 50 mg 695.00$ in stock
66020 100 mg 1190.00$ in stock
Bulk inquiry

Cyanine7.5 is a NIR dye with very long-wave emission. This product is amine-reactive derivative of this fluorophore.

Near infrared radiation readily penetrates tissues and can be used for imaging applications in vivo.

This product can be used for the labeling of various biomolecules containing amine groups, such as proteins and peptides, to track their distribution in organism in vivo by NIR imaging.

Increased rigidity of central polymethyne moiety allows to increase quantum yield by 20% compared to parent structure of Cy7.5® NHS.

Cyanine7.5 NHS ester
Cyanine7.5 NHS ester
Cyanine7.5 NHS ester
Cy7.5 NHS ester structure
Download in
ChemDraw format

Cy7.5 absorbance and emission spectra

Cy7.5 absorbance and emission spectra

Customers also purchased with this product

dsGreen Gel Staining Solution, 10000×

dsGreen, a SYBR Green I analog for staining dsDNA in gels

BDP FL NHS ester

Amino-reactive BDP FL, a very bright and photostable dye for fluorescein channel.

Sulfo-Cyanine5 carboxylic acid

Water-soluble Cyanine5 carboxylic acid, non-activated fluorescent dye.

Recommended protocol

NHS ester labeling of amino biomolecules

General properties

Appearance: green powder
Molecular weight: 782.41
Molecular formula: C49H52ClN3O4
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download

Spectral properties

Excitation maximum, nm: 788
ε, L⋅mol−1⋅cm−1: 223000
Emission maximum, nm: 808

Product citations

  1. Loebel, C.; Rodell, C.B.; Chen, M.H.; Burdick, J.A. Shear-thinning and self-healing hydrogels as injectable therapeutics and for 3D-printing. Nature Protocols, 2017, 12(8), 1521–1541. doi: 10.1038/nprot.2017.053
  2. O'Mary, H.L.; Aldayel, A.M.; Valdes, S.A.; Naguib, Y.W.; Li, X.; Salvady, K.; Cui, Z. Acid-sensitive sheddable PEGylated, mannose-modified nanoparticles increase the delivery of betamethasone to chronic inflammation sites in a mouse model. Molecular Pharmaceutics, 2017, 14(6), 1929–1937. doi: 10.1021/acs.molpharmaceut.7b00024
  3. Sivak, L.; Subr, V.; Tomala, J.; Rihova, B.; Strohalm, J.; Etrych, T.; Kovar, M. Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate. Biomaterials, 2017, 115, 65–80. doi: 10.1016/j.biomaterials.2016.11.013
  4. Lin, S.; Shah, A.; Hernández-Gil, J.; Stanziola, A.; Harriss, B.I.; Matsunaga, T.O.; Long, N.; Bamber, J.; Tang, M.-X. Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging. Photoacoustics, 2017, 6, 26–36. doi: 10.1016/j.pacs.2017.04.001
  5. Cheng, J.; Feng, S.; Han, S.; Zhang, X.; Chen, Y.; Zhou, X.; Wang, R.; Li, X.; Hu, H.; Zhang, J. Facile Assembly of Cost-Effective and Locally Applicable or Injectable Nanohemostats for Hemorrhage Control. ACS Nano, 2016, 10(11), 9957&ndash9973. doi: 10.1021/acsnano.6b04124
  6. Zhang, Q.; Tao, H.; Lin, Y.; Hu, Y.; An, H.; Zhang, D.; Feng, S.; Hu, H.; Wang, R.; Li, X.; Zhang, J. A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease. Biomaterials, 2016, 105, 206–221. doi: 10.1016/j.biomaterials.2016.08.010
  7. Feng, S.; Hu, Y.; Peng, S.; Han, S.; Tao, H.; Zhang, Q.; Xu, X.; Zhang, J.; Hu, H. Nanoparticles responsive to the inflammatory microenvironment for targeted treatment of arterial restenosis. Biomaterials, 2016, 105, 167–184. doi: 10.1016/j.biomaterials.2016.08.003
  8. Dou, Y.; Guo, J.; Chen, Y.; Han, S.; Xu, X.; Shi, Q.; Jia, Y.; Liu, Y.; Deng, Y.; Wang, R.; Li, X.; Zhang, J. Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice. Journal of Controlled Release, 2016, 235, 48–62. doi: 10.1016/j.jconrel.2016.05.049
  9. Markovic, S.; Belz, J.; Kumar, R.; Cormack, R.A.; Sridhar, S.; Niedre, M. Near-infrared fluorescence imaging platform for quantifying in vivo nanoparticle diffusion from drug loaded implants. International Journal of Nanomedicine, 2016, 11, 1213–1223. doi: 10.2147/IJN.S93324
  10. Zhang, Z.; Cai, H.; Liu, Z.; Yao, P. Effective Enhancement of Hypoglycemic Effect of Insulin by Liver-targeted Nanoparticles Containing Cholic Acid-modified Chitosan Derivative. Molecular Pharmaceutics, 2016, 13(7), 2433–2442. doi: 10.1021/acs.molpharmaceut.6b00188
  11. Han, F.Y.; Thurecht, K.J.; Lam, A.-L.; Whittaker, A.K.; Smith, M.T. Novel Polymeric Bioerodable Microparticles for Prolonged-Release Intrathecal Delivery of Analgesic Agents for Relief of Intractable Cancer-Related Pain. Journal of Pharmaceutical Sciences, 2015, 104(7), 2334–2344. doi: 10.1002/jps.24497
  12. Duong, H.T.T.; Dong, Z.; Su, L; Boyer, C.; George, J.; Davis, T.P.; Wang, J. The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension. Small, 2015, 11(19), 2291–2304. doi: 10.1002/smll.201402870
  13. Chen, K.; Xu, X.; Guo, J.W.; Zhang, X.; Han, S.; Wang, R.; Li, X.; Zhang, J. Enhanced Intracellular Delivery and Tissue Retention of Nanoparticles by Mussel-Inspired Surface Chemistry. Biomacromolecules, 2015, 16(11), 3574–3583. doi: 10.1021/acs.biomac.5b01056
  14. Lin, Y.-A.; Cheetham, A.G.; Zhang, P.; Ou, Y.-C.; Li, Y.; Liu, G.; Hermida Merino, D.; Hamley, I.W.; Cui, H. Multi-Walled Nanotubes Formed by Catanionic Mixtures of Drug Amphiphiles. ACS Nano, 2014, 8(12), 12690-12700. doi: 10.1021/nn505688b
  15. Graen, T.M.D.; Hoefling, M.; Grubmüller, H. AMBER-DYES: Characterization of Charge Fluctuations and Force Field Parameterization of Fluorescent Dyes for Molecular Dynamics Simulations. Journal of Chemical Theory and Computation, 2014, 10(12), 5505-5512. doi: 10.1021/ct500869p
  16. Lu, H.D.; Soranno, D.E.; Rodell, C.B.; Kim, I.L.; Burdick, J.A. Secondary Photocrosslinking of Injectable Shear-Thinning Dock-and-Lock Hydrogels. Advanced Healthcare Materials, 2013, 2(7), 1028-1036. doi: 10.1002/adhm.201200343
  17. Yang, H.; Mao, H.; Wan, Z.; Zhu, A.; Guo, M.; Li, Y.; Li, X.; Wan, J.; Yang, X.; Shuai, X. et al. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials, 2013, 34(36), 9124-9133. doi: 10.1016/j.biomaterials.2013.08.022
  18. Zhou, K.; Liu, H.; Zhang, S.; Huang, X.; Wang, Y.; Huang, G.; Sumer, B.D.; Gao, J. Multicolored pH-Tunable and Activatable Fluorescence Nanoplatform Responsive to Physiologic pH Stimuli. Journal of the American Chemical Society, 2012, 134(18), 7803-7811. doi: 10.1021/ja300176w
Show more (14)
Cy® is a trademark of GE Healthcare.
Your item has been added. View your cart or proceed to checkout
The count of items is incorrect.
translate