DMS(O)MT aminolink C6

Phosphoramidites

Cat. #	Quantity	Price	Lead time
23260 / in 6 mL septum	250 mg	$140	in stock
43260 / in 6 mL septum	1 g	$350	in stock
63260	5 g	$1280	in stock
83260	10 g	$2540	in stock
93260	25 g	please inquire	in stock

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Aminolink phosphoramidite for oligonucleotide synthesis. DMS(O)MT is a special protective group similar to traditional MMT, but designed as an improved alternative to it. DMS(O)MT aminolink is fully compatible with standard coupling, deblock, and purification protocols. However, DMS(O)MT group is much better suited for DMT-on and cartridge purification of amino-oligonucleotides because of higher stability, and better oligonucleotide recovery. Oligonucleotides containing DMS(O)MT are more stable in solution than MMT analogs.

In case of cartridge purification, DMS(O)MT protection allows for 2-3 fold increase of oligonucleotide yield, making this reagent a unique solution for high-throughput manufacturing of amino-oligonucleotides.

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General properties

Appearance:	yellowish viscous oil
Molecular weight:	681.86
CAS number:	1173109-53-9
Molecular formula:	C₃₇H₅₂N₃O₅PS
Solubility:	soluble in acetonitrile, dichloromethane
Quality control:	NMR ¹H, ³¹P, HPLC (95%)
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks.
MSDS:	Download
	Product specifications

Oligo synthesis details

Diluent:	acetonitrile
Coupling conditions:	standard coupling, identical to normal nucleobases
Cleavage conditions:	ammonia, 2 h at room temperature; if an oligonucleotide with trityl group needs to be evaporated, add small amount of Tris base before it, or trityl group can be lost.
Deprotection conditions:	identical to protected nucleobases. Trityl group can be removed by acidic cleavage in either 80% acetic acid, or on C₁₈ cartridge during purification using 2% to 4% trifluoroacetic acid.

Product citations

Novopashina, D.; Vorobyeva, M.; Nazarov, A.; Davydova, A.; Danilin, N.; Koroleva, L.; Matveev, A.; Bardasheva, A.; Tikunova, N.; Kupryushkin, M.; Pyshnyi, D.; Altman, S.; Venyaminova, A. Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P. Frontiers in Pharmacology, 2019, 10, 813. doi: 10.3389/fphar.2019.00813
Aparin, I.O.; Farzan, V.M.; Veselova, O.A.; Chistov, A.A.; Podkolzin, A.T.; Ustinov, A.V.; Shipulin, G.A.; Formanovsky, A.A.; Korshun, V.A.; Zatsepin, T.S. 1-Phenylethynylpyrene (PEPy) as a novel blue-emitting dye for qPCR assay. Analyst, 2016, 141, 1331–1338. doi: 10.1039/c5an01767j

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.