DMS(O)MT aminolink C6

Cat. # Quantity Price Lead time
23260 250 mg $140 in stock
43260 1 g $350 in stock
63260 5 g $1280 in stock
83260 10 g $2540 5 days
93260 25 g please inquire in stock
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Aminolink phosphoramidite for oligonucleotide synthesis. DMS(O)MT is a special protective group similar to traditional MMT, but designed as an improved alternative to it. DMS(O)MT aminolink is fully compatible with standard coupling, deblock, and purification protocols. However, DMS(O)MT group is much better suited for DMT-on and cartridge purification of amino-oligonucleotides because of higher stability, and better oligonucleotide recovery. Oligonucleotides containing DMS(O)MT are more stable in solution than MMT analogs.

In case of cartridge purification, DMS(O)MT protection allows for 2-3 fold increase of oligonucleotide yield, making this reagent a unique solution for high-throughput manufacturing of amino-oligonucleotides.

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General properties

Appearance: yellowish viscous oil
Molecular weight: 681.86
CAS number: 1173109-53-9
Molecular formula: C37H52N3O5PS
Solubility: soluble in acetonitrile, dichloromethane
Quality control: NMR 1H, 31P, HPLC (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks.
MSDS: Download
Product specifications

Oligo synthesis details

Diluent: acetonitrile
Coupling conditions: standard coupling, identical to normal nucleobases
Cleavage conditions: ammonia, 2 h at room temperature; if an oligonucleotide with trityl group needs to be evaporated, add small amount of Tris base before it, or trityl group can be lost.
Deprotection conditions: identical to protected nucleobases. Trityl group can be removed by acidic cleavage in either 80% acetic acid, or on C18 cartridge during purification using 2% to 4% trifluoroacetic acid.

Product citations

  1. Novopashina, D.; Vorobyeva, M.; Nazarov, A.; Davydova, A.; Danilin, N.; Koroleva, L.; Matveev, A.; Bardasheva, A.; Tikunova, N.; Kupryushkin, M.; Pyshnyi, D.; Altman, S.; Venyaminova, A. Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P. Frontiers in Pharmacology, 2019, 10, 813. doi: 10.3389/fphar.2019.00813
  2. Aparin, I.O.; Farzan, V.M.; Veselova, O.A.; Chistov, A.A.; Podkolzin, A.T.; Ustinov, A.V.; Shipulin, G.A.; Formanovsky, A.A.; Korshun, V.A.; Zatsepin, T.S. 1-Phenylethynylpyrene (PEPy) as a novel blue-emitting dye for qPCR assay. Analyst, 2016, 141, 1331–1338. doi: 10.1039/c5an01767j
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