DBCO NHS ester
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
34720 | 10 mg | $80.00 | 5 days | |
44720 | 25 mg | $110.00 | 5 days | |
54720 | 50 mg | $135.00 | 5 days | |
64720 | 100 mg | $210.00 | in stock | |
94720 | 1 g | $1000.00 | 5 days | |
K4720 | 5 g | $3570.00 | 5 days |
Dibenzocyclooctyne (ADIBO, DBCO) is one of the most reactive cycloalkynes for strain-promoted alkyne azide cycloaddition (SPAAC) – a copper-free click chemistry reaction.
DBCO reacts instantly with azides. The reaction rate is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines - this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines.
This amine-reactive NHS ester provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.
Customers also purchased with this product
AmdU (5-Azidomethyl-2'-deoxyuridine)
Azidomethyldeoxyuridine (AmdU) is an azide-contained nucleoside that is incorporated into nascent DNA by cellular polymerases. The azide groups attached to DNA this way can be subsequently modified with alkynes or cycloalkynes via copper-catalyzed or strain-promoted click reaction.FAM alkyne, 6-isomer
Fluorescein dye alkyne for click chemistry conjugation, pure 6-isomer.Azide-PEG4-amine
PEG4 amine azide is a bifunctional linker with amine and azide functional groups. It is based on a tetraethyleneglycol core. The length of the PEG4 linker is 1.4 nm.General properties
Appearance: | off white solid |
Mass spec M+ increment: | 315.1 |
Molecular weight: | 430.45 |
CAS number: | 1384870-47-6 |
Molecular formula: | C25H22N2O5 |
IUPAC name: | 6-{2-Azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-6-oxohexanamide |
Solubility: | good in DCM, DMF, DMSO |
Quality control: | NMR 1H, HPLC-MS (95%) |
Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
MSDS: | Download |
Product specifications |
Product citations
- Gabold, B.; Adams, F.; Brameyer, S.; Jung, K.; Ried, C. L.; Merdan, T.; Merkel, O. M. Transferrin-Modified Chitosan Nanoparticles for Targeted Nose-to-Brain Delivery of Proteins. Drug Deliv. and Transl. Res., 2023, 13(3), 822–838. doi: 10.1007/s13346-022-01245-z
- Edr, A.; Wrobel, D.; Krupková, A.; Šťastná, L. Č.; Cuřínová, P.; Novák, A.; Malý, J.; Kalasová, J.; Malý, J.; Malý, M.; Strašák, T. Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects. International Journal of Molecular Sciences, 2022, 23(4), 2114. doi: 10.3390/ijms23042114
- Jo, M. H.; Li, J.; Jaumouillé, V.; Hao, Y.; Coppola, J.; Yan, J.; Waterman, C. M.; Springer, T. A.; Ha, T. Single-Molecule Characterization of Subtype-Specific Β1 Integrin Mechanics. Nature Communications, 2022, 13(1), 7471. doi: 10.1038/s41467-022-35173-w
- Xu, L.; Faruqu, F.N.; Liam-or, R.; Abu Abed, O.; Li, D.; Venner, K.; Errington, R.J.; Summers, H.; Wang, J.T.-W.; Al-Jamal, K.T. Design of experiment (DoE)-driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copper-free click chemistry-based labelling. Journal of Extracellular Vesicles, 2020, 9(1), 1779458. doi: 10.1080/20013078.2020.1779458