DBCO NHS ester
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
34720 | 10 mg | $80.00 | in stock | |
44720 | 25 mg | $110.00 | in stock | |
54720 | 50 mg | $135.00 | in stock | |
64720 | 100 mg | $210.00 | in stock | |
94720 | 1 g |
$1000.00
|
in stock | |
K4720 | 5 g |
$3570.00
|
in stock |
Dibenzocyclooctyne (ADIBO, DBCO) is one of the most reactive cycloalkynes for strain-promoted alkyne azide cycloaddition (SPAAC) – a copper-free click chemistry reaction.
DBCO reacts instantly with azides. The reaction rate is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines - this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines.
This amine-reactive NHS ester provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.
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General properties
Appearance: | off white solid |
Mass spec M+ increment: | 315.1 |
Molecular weight: | 430.45 |
CAS number: | 1384870-47-6 |
Molecular formula: | C25H22N2O5 |
IUPAC name: | 6-{2-Azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-6-oxohexanamide |
Solubility: | good in DCM, DMF, DMSO |
Quality control: | NMR 1H, HPLC-MS (95%) |
Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
MSDS: | Download |
Product specifications |
Product citations
- Gabold, B.; Adams, F.; Brameyer, S.; Jung, K.; Ried, C. L.; Merdan, T.; Merkel, O. M. Transferrin-Modified Chitosan Nanoparticles for Targeted Nose-to-Brain Delivery of Proteins. Drug Deliv. and Transl. Res., 2023, 13(3), 822–838. doi: 10.1007/s13346-022-01245-z
- Edr, A.; Wrobel, D.; Krupková, A.; Šťastná, L. Č.; Cuřínová, P.; Novák, A.; Malý, J.; Kalasová, J.; Malý, J.; Malý, M.; Strašák, T. Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects. International Journal of Molecular Sciences, 2022, 23(4), 2114. doi: 10.3390/ijms23042114
- Jo, M. H.; Li, J.; Jaumouillé, V.; Hao, Y.; Coppola, J.; Yan, J.; Waterman, C. M.; Springer, T. A.; Ha, T. Single-Molecule Characterization of Subtype-Specific Β1 Integrin Mechanics. Nature Communications, 2022, 13(1), 7471. doi: 10.1038/s41467-022-35173-w
- Adams, M.R.; Moody, C.T.; Sollinger, J.L.; Brudno, Y. Extracellular Matrix-Anchored Click Motifs for Specific Tissue Targeting. Molecular Pharmaceutics, 2020, 17(2), 392–403. doi: 10.1021/acs.molpharmaceut.9b00589
