Cyanine5.5 NHS ester

Cat. # Quantity Price Lead time
17020 1 mg $110.00 in stock
27020 5 mg $210.00 in stock
47020 25 mg $410.00 in stock
57020 50 mg $695.00 in stock
67020 100 mg $1190.00 in stock

Cyanine5.5 NHS ester is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides, an analog of Cy5.5® NHS ester.

Cy5.5 is a far-red (and near-infrared) emitting dye which is ideal for fluorescence measurements where background fluorescence is a concern. It is also suitable for in vivo NIR imaging experiments.

This reagent can replace NHS esters of Cy5.5®, Alexa Fluor 680, and DyLight 680.

Cy5.5 absorbance and emission spectra

Cy5.5 absorbance and emission spectra

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General properties

Appearance: dark blue solid
Molecular weight: 767.66
CAS number: 2375105-86-3
Molecular formula: C44H46N3BF4O4
IUPAC name: 1H-​Benz[e]​indolium, 2-​[5-​(1,​3-​dihydro-​1,​1,​3-​trimethyl-​2H-​benz[e]​indol-​2-​ylidene)​-​1,​3-​pentadien-​1-​yl]​-​3-​[6-​[(2,​5-​dioxo-​1-​pyrrolidinyl)​oxy]​-​6-​oxohexyl]​-​1,​1-​dimethyl-
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), practically insoluble in water (< 1 uM, < 1 mg/L)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation/absorption maximum, nm: 684
ε, L⋅mol−1⋅cm−1: 198000
Emission maximum, nm: 710
Fluorescence quantum yield: 0.2
CF260: 0.07
CF280: 0.03

Product citations

  1. Umebara, M.; Sugai, N.; Murayama, K.; Sugawara, T.; Akashi, Y.; Morita, Y.; Kato, R.; Komatsu, T. Catalase-driven protein microtube motors with different exterior surfaces as ultrasmall biotools. Materials Advances, in press. doi: 10.1039/D1MA00610J
  2. Chung, I.J.; Moon, H.; Jeon, S.I.; Lee, H.J.; Ahn, C.-H. Ultrasound-triggered imaging and drug delivery using microbubble-self-aggregate complexes. Journal of Biomaterials Science, Polymer Edition, in press. doi: 10.1080/09205063.2021.1976362
  3. Son, S.; Shin, J.M.; Shin, S.; Kim, C.H.; Lee, J.A.; Ko, H.; Lee, E.S.; Jung, J.M:; Kim, J.; Park, J.H. Repurposing macitentan with nanoparticle modulates tumor microenvironment to potentiate immune checkpoint blockade. Biomaterials, 2021, 276, 121058. doi: 10.1016/j.biomaterials.2021.121058
  4. Pham, L.M.; Poudel, K.; Phung, C.D.; Nguyen, T.T.; Pandit, M.; Nguyen, H.T.; Chang, J.-H.; Jin, S.G.; Jeong, J.-H.; Ku, S.K.; Choi, H.-G.; Yong, C.S.; Kim, J.O. Preparation and evaluation of dabrafenib-loaded, CD47-conjugated human serum albumin-based nanoconstructs for chemoimmunomodulation. Colloids and Surfaces B: Biointerfaces, 2021, 208, 112093. doi: 10.1016/j.colsurfb.2021.112093
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