Sulfo-Cyanine3 maleimide

Cat. # Quantity Price Lead time
11380 1 mg $110.00 5 days
21380 5 mg $290.00 in stock
41380 25 mg $690.00 in stock
51380 50 mg $1270.00 in stock
61380 100 mg $1990.00 in stock

Sulfo-Cyanine3 maleimide is a water soluble, thiol reactive dye for the labeling with hydrophilic sulfo-Cyanine3 fluorophore. This is an analog of Cy3® maleimide.

This product is recommended for the labeling of antibodies and other labile proteins in mild, purely aqueous conditions. The dye is water soluble and does not require use of organic co-solvent.

A non-sulfonated Cyanine3 maleimide is available.

Sulfo-Cyanine3 maleimide

Sulfo-Cyanine3 maleimide

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General properties

Appearance: red powder
Molecular weight: 776.96
CAS number: 1656990-68-9
Molecular formula: C36H41KN4O9S2
IUPAC name: 3H-​Indolium, 2-​[3-​[1-​[6-​[[2-​(2,​5-​dihydro-​2,​5-​dioxo-​1H-​pyrrol-​1-​yl)​ethyl]​amino]​-​6-​oxohexyl]​-​1,​3-​dihydro-​3,​3-​dimethyl-​5-​sulfo-​2H-​indol-​2-​ylidene]​-​1-​propen-​1-​yl]​-​1,​3,​3-​trimethyl-​5-​sulfo-​, inner salt, potassium salt
Solubility: soluble in water (0.39 M = 30 g/L), DMF, DMSO
Quality control: NMR 1H, HPLC-MS (95+%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 548
ε, L⋅mol−1⋅cm−1: 162000
Emission maximum, nm: 563
Fluorescence quantum yield: 0.1
CF260: 0.03
CF280: 0.06

Product citations

  1. Wouters, S.; Vugs, W.; Arts, R.; de Leeuw, N.; Teeuwen, R.; Merkx, M. Bioluminescent antibodies through photoconjugation of protein-G-luciferase fusion proteins. Bioconjugate Chemistry, in press. doi: 10.1021/acs.bioconjchem.9b00804
  2. Baksheeva, V.E.; Nemashkalova, E.L.; Firsov, A.M.; Zalevsky, A.O.; Vladimirov, V.I.; Tikhomirova, N.K.; Philippov, P.P.; Zamyatnin, A.A.; Zinchenko, D.V.; Antonenko, Y.N.; Permyakov, S.E.; Zernii, E.Y. Membrane Binding of Neuronal Calcium Sensor-1: Highly Specific Interaction with Phosphatidylinositol-3-Phosphate. Biomolecules, 2020, 10, 164. doi: 10.3390/biom10020164
  3. Zhang, N.; Shi, S.; Jia, T.Z.; Ziegler, A.; Yoo, B.; Yuan, X.; Li, W.; Zhang, S. A general LC-MS-based RNA sequencing method for direct analysis of multiple-base modifications in RNA mixtures. Nucleic Acids Research, 2019, 47(20), e125. doi: 10.1093/nar/gkz731
  4. Cundiff, M.D.; Hurley, C.M.; Wong, J.D.; Boscia, J.A.; Bashyal, A.; Rosenberg, J:; Reichard, E.L.; Nassif, N.D.; Brodbelt, J.S.; Kraut, D.A. Ubiquitin receptors are required for substrate-mediated activation of the proteasome's unfolding ability. Scientific Reports, 2019, 9, 14506. doi: 10.1038/s41598-019-50857-y
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