Activated esters
Primary or secondary amino groups are ubiquitous in biomolecules. They are present in proteins and peptides as ε-amino groups of lysines and N-terminal amino groups. Many natural and synthetic small molecules are amines, and DNAs with amino groups can be prepared by solid phase synthesis, and enzymatically.
Amino groups can be modified by acylation with various activated carbonyl compounds. Among these compounds, activated N-hydroxysuccinimide esters are most suitable for biolabeling and bioconjugation applications.
Compared to other activated esters, NHS derivatives possess good stability in aqueous environment. Optimal pH for the coupling of amines with NHS esters in aqueous buffers is 8.3-8.5. Labeling is also possible in organic solvents. Polar aprotic solents, such as DMF or DMSO, are preferred. One equivalent of tertiary amine base, such as triethylamine, or diisopropylethylamine (DIPEA) is necessary to achieve efficient amine acylation in non-aqueous solution.
3-Maleimidopropionic acid NHS-ester
Bifunctional crosslinker with an amine-reactive succinimidyl ester and a thiol-reactive maleimide group.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3419-100mg | 100 mg | – | in stock | |
| 3419-500mg | 500 mg | $110 | in stock |
Alkyne-PEG2-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2219-1g | 1 g |
$450
|
in stock | |
| 2219-5g | 5 g |
$980
|
in stock |
Alkyne-PEG3-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2298-1g | 1 g |
$490
|
in stock | |
| 2298-5g | 5 g |
$980
|
in stock |
Alkyne-PEG4-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2409-100mg | 100 mg | $250 | in stock | |
| 2409-1g | 1 g |
$790
|
in stock |
ATFB SE (N-Succinimidyl 4-Azidotetrafluorobenzoate)
N-Succinimidyl 4-Azidotetrafluorobenzoate (ATFB SE, ATFB-OSu) is a photo-activatable linker used as a versatile labeling agent for investigating biological receptors.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2574-250mg | 250 mg | $134 | in stock | |
| 2574-1g | 1 g |
$419
|
in stock |
Azide-PEG6-NHS ester
A hydrophilic bifunctional linker with azide and NHS ester function groups flanking PEG6 (hexaethylene glycol).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3692-250mg | 250 mg | $325 | in stock | |
| 3692-1g | 1 g |
$539
|
in stock |
Azidobutyric acid NHS ester
Activated NHS ester for azido-labeling of peptides and proteins.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 53720 | 50 mg | $110 | in stock | |
| 63720 | 100 mg | $210 | in stock | |
| 73720 | 1 g |
$950
|
in stock | |
| 83720 | 5 g | please inquire | in stock |
Biotin-PEG4-NHS ester
PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2893-100mg | 100 mg | $145 | in stock | |
| 2893-1g | 1 g |
$590
|
in stock |
Biotin-XX-NHS ester
Biotin derivative with long spacer to reduce steric effect when binding amino acids, peptides, or proteins by reacting with primary amines.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2897-100mg | 100 mg | $225 | in stock | |
| 2897-1g | 1 g |
$670
|
in stock |
DBCO-NHS ester
Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 34720 | 10 mg | $80 | in stock | |
| 44720 | 25 mg | $110 | in stock | |
| 54720 | 50 mg | $135 | in stock | |
| 64720 | 100 mg | $178 | in stock | |
| 94720 | 1 g |
$970
|
in stock | |
| K4720 | 5 g |
$2990
|
in stock |
DBCO-PEG6-NHS ester
A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3664-10mg | 10 mg | – | in stock | |
| 3664-50mg | 50 mg | $247 | in stock | |
| 3664-100mg | 100 mg |
$449
|
in stock | |
| 3664-1g | 1 g |
$3490
|
5 days |
DBCO-STP ester
Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2584-5mg | 5 mg | – | in stock | |
| 2584-10mg | 10 mg | $90 | in stock | |
| 2584-25mg | 25 mg | $180 | in stock | |
| 2584-100mg | 100 mg |
$450
|
in stock | |
| 2584-500mg | 500 mg |
$1700
|
in stock | |
| 2584-1g | 1 g |
$3000
|
in stock | |
| 2584-5g | 5 g | please inquire | in stock |
Disuccinimidyl glutarate (DSG)
Homobifunctional crosslinker with two NHS ester groups at each end of a short 5-atom (7.7 angstrom) spacer.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4018-100mg | 100 mg | $95 | in stock | |
| 4018-1g | 1 g |
$410
|
in stock |
Exo-BCN-PNP
BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4043-100mg | 100 mg | $280 | in stock | |
| 4043-500mg | 500 mg |
$990
|
in stock |
Hexynoic acid NHS ester
Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 41720 | 25 mg | $95 | in stock | |
| 51720 | 50 mg | $180 | in stock | |
| 61720 | 100 mg | $290 | in stock | |
| 91720 | 1 g | please inquire | in stock |
Hexynoic acid STP ester
Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 569-25mg | 25 mg | $95 | in stock | |
| 569-100mg | 100 mg | $185 | in stock | |
| 569-500mg | 500 mg |
$850
|
in stock |
Pentynoic acid STP ester
An activated ester for the introduction of alkyne into peptides/proteins and click reaction.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 30720 | 10 mg | $110 | in stock | |
| 40720 | 25 mg | $210 | in stock | |
| 50720 | 50 mg |
$410
|
in stock | |
| 60720 | 100 mg |
$595
|
10 days |
TCO-PEG4-NHS ester (axial isomer)
A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3056-10mg | 10 mg | $145 | in stock | |
| 3056-25mg | 25 mg | $225 | in stock | |
| 3056-100mg | 100 mg |
$550
|
in stock |
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