Azidobutyric acid NHS ester

Cat. # Quantity Price Lead time
53720 50 mg $110.00 in stock
63720 100 mg $210.00 in stock
73720 1 g $950.00 in stock
83720 5 g please inquire in stock

Convert your proteins and peptides into click chemistry reactive form with this reagent.

While click chemistry involves reaction between terminal alkyne and azide, both azides and alkynes are very uncommon in nature. However, there are reagents to attach these fragments to abundant amino groups which are ubiquitous in the world of biomolecules. This azido-NHS ester is designed for the conversion of proteins, peptides, amino-DNA, and other amines into click chemistry reactive azides.

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General properties

Appearance: colorless solid
Mass spec M+ increment: 111.0
Molecular weight: 226.19
CAS number: 943858-70-6
Molecular formula: C8H10N4O4
IUPAC name: Butanoic acid, 4-​azido-​, 2,​5-​dioxo-​1-​pyrrolidinyl ester
Solubility: soluble in organic solvents (DMF, DMSO)
Quality control: NMR 1H (95%), HPLC
Storage conditions: Storage: 12 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications

Product citations

  1. Sim, J.; Li, M.; Park, K. M.; Kim, K. Identification of Mitochondrial Proteins Associated with Cyanine 5 Using a Combination of Affinity-Based Photocrosslinking with Bio-Orthogonal Supramolecular Latching. J. Porphyrins Phthalocyanines, 2023, 27(07n10), 1148–1155. doi: 10.1142/S108842462350058X
  2. Mauser, A.; Quevedo, D. F.; Zhang, B.; Hernandez, Y.; Berardi, A.; Brown, W.; Lee, S.; Miki, R.; Raymond, J.; Lahann, J.; Greineder, C. F. Enzyme-Based Synthetic Protein Nanoparticles as Colloidal Antioxidants , 2023, 2300007. doi: 10.1002/adtp.202300007
  3. Jo, M. H.; Li, J.; Jaumouillé, V.; Hao, Y.; Coppola, J.; Yan, J.; Waterman, C. M.; Springer, T. A.; Ha, T. Single-Molecule Characterization of Subtype-Specific Β1 Integrin Mechanics. Nature Communications, 2022, 13(1), 7471. doi: 10.1038/s41467-022-35173-w
  4. Wang, Y.; Yao, J.; Cai, L.; Liu, T.; Wang, X.; Zhang, Y.; Zhou, Z.; Li, T.; Liu, M.; Lai, R.; Liu, X. Bone-Targeted Extracellular Vesicles from Mesenchymal Stem Cells for Osteoporosis Therapy. IJN, 2020, 15, 7967–7977. doi: 10.2147/IJN.S263756
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