Alkyne-PEG4-maleimide

Alkynes Click chemistry Maleimides Crosslinking

Cat. #	Quantity	Price	Lead time	Buy this product
2002-100mg	100 mg	$150	in stock
2002-1g	1 g	$590	in stock

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When proteins or other sensitive biomolecules need to be conjugated, polyethyleneglycol (PEG) linkers are a great choice. They provide hydrophilicity and maintain separation between conjugated molecules. This linker based on PEG4, has length of 14Å (1.4 nm). Heterobifunctional linkers carrying different reactive groups can be used to prepare cross-conjugates between different molecules.

Maleimide functional group is especially useful, because they can label proteins site specifically. Most proteins have only limited number of cysteine residues that selectively react with maleimides. Alkyne group can be then conjugated with azides in a selective copper-catalyzed process, CuAAC (copper-catalyzed alkyne-azide cycloaddition).

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Conjugation of Alkyne- or Azide-modified Proteins with Dye Azides or Alkynes

Maleimide Labeling of Proteins and Other Thiolated Biomolecules

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General properties

Appearance:	yellow oil
Mass spec M+ increment:	311.3
Molecular weight:	311.33
CAS number:	1262681-30-0
Molecular formula:	C₁₅H₂₁NO₆
Solubility:	good in water, DMF, DMSO
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download
	Product specifications

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.