Alkyne NHS ester (hexynoic acid NHS ester)

Cat. # Quantity Price Lead time
41720 25 mg $95.00 5 days
51720 50 mg $180.00 in stock
61720 100 mg $290.00 in stock
91720 1 g please inquire in stock

Alkyne NHS ester for the modification of biomolecules. Alkyne groups for copper catalyzed Click Chemistry reaction are nearly never encountered in natural molecules. However, this NHS ester allows to attach alkyne groups to amino groups, which are ubiquitous in nature, and which are present in proteins, peptides, synthetic amino-DNA and numerous small molecules. Alkyne groups can be subsequently modified and conjugated by Copper catalyzed Click chemistry.

This reagent is a derivative of hexynoic acid.

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General properties

Appearance: yellowish oil / off white crystals
Mass spec M+ increment: 94.0
Molecular weight: 209.20
CAS number: 906564-59-8
Molecular formula: C10H11NO4
IUPAC name: 5-​Hexynoic acid, 2,​5-​dioxo-​1-​pyrrolidinyl ester
Solubility: good in organic solvents (DMF, DMSO, DCM)
Quality control: NMR 1H 95+%
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Product citations

  1. Zanon, P.R.A.; Yu, F.; Musacchio, P.; Lewald, L.; Zollo, M.; Krauskopf, K.; Mrdović, D.; Raunft, P.; Maher, T.E.; Cigler, M.; Chang, C.; Lang, K.; Toste, F.D.; Nesvizhskii, A.I.; Hacker, S.M. Profiling the proteome-wide selectivity of diverse electrophiles. ChemRxiv, preprint. doi: 10.33774/chemrxiv-2021-w7rss-v2
  2. Kleinpenning, F.; Steigenberger, B.; Wu, W.; Heck, A.J.R. Fishing for newly synthesized proteins with phosphonate-handles. Nature Communications, 2020, 11, 3244. doi: 10.1038/s41467-020-17010-0
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