Potentiometric probes are voltage-sensitive dyes that change their spectral properties in response to electric potential changes. They allow linear measurements of the firing activity of electrically active cells: neurons, myocytes, and some secretory cells. Potentiometric dyes are used to measure spatial and temporal fluctuations in potential across the membrane of single cells and large cell populations. It also makes it possible to monitor the electrical activity inside cell organelles like mitochondria and dendritic spines, where direct electrode insertion is not feasible.
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