Cycloalkenes in Reactive groups
Cycloalkenes are strained alkenes, tetrazine-reactive derivatives for inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).
Trans-cyclooctene (TCO) is one of the most used cycloalkenes for bioconjugation tasks. TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, high yielding, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.
AF 488 TCO
AF 488-containing derivative of trans-cyclooctene (TCO) for conjugation with tetrazine via the inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 118H0 | 1 mg | $199 | 12 days | |
| 218H0 | 5 mg |
$649
|
12 days | |
| 418H0 | 25 mg |
$1789
|
12 days |
TCO phosphoramidite C6
Trans-cyclooctene (TCO) amidite is used to introduce a TCO moiety into substrates containing primary or secondary hydroxyl group
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4017-250mg | 250 mg |
$920
|
in stock | |
| 4017-1g | 1 g | please inquire | 12 days |
TCO-PEG4-NHS ester (axial isomer)
A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3056-10mg | 10 mg | $145 | in stock | |
| 3056-25mg | 25 mg | $225 | in stock | |
| 3056-100mg | 100 mg |
$550
|
in stock |
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