Cycloalkenes in Reactive groups

Cycloalkenes are strained alkenes, tetrazine-reactive derivatives for inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).

Trans-cyclooctene (TCO) is one of the most used cycloalkenes for bioconjugation tasks. TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, high yielding, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.

AF 488 TCO

AF 488-containing derivative of trans-cyclooctene (TCO) for conjugation with tetrazine via the inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).

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Cat. #	Quantity	Price	Lead time
118H0	1 mg	$199	in stock
218H0	5 mg	$649	in stock
418H0	25 mg	$1789	in stock

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TCO phosphoramidite C6

Trans-cyclooctene (TCO) amidite is used to introduce a TCO moiety into substrates containing primary or secondary hydroxyl group

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Cat. #	Quantity	Price	Lead time
4017-100mg	100 mg	$480	in stock
4017-250mg	250 mg	$920	in stock
4017-1g	1 g	please inquire	in stock

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TCO-PEG4-NHS ester (axial isomer)

A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.

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