Bioconjugation reagents

Bioconjugation reagents / product groups & items in this category
Bioconjugation reagents: biotin, streptavidin, biotinylation reagents, bifunctional cross-linkers, PEG-linkers, auxiliary reagents for click chemistry, etc.

Activated esters

Bifunctional activated NHS and STP esters for binding with primary and secondary amine groups.
Group tags Crosslinking, NHS esters, Cycloalkenes, Copper-free click chemistry, STP esters, Biotinylation, Cycloalkynes, Maleimides, Azides, Alkynes, Click chemistry, Protein labeling
    • Pentynoic acid STP ester
      An activated ester for the introduction of alkyne into peptides/proteins and click reaction.
    • Azide-PEG6-NHS ester
      A hydrophilic bifunctional linker with azide and NHS ester function groups flanking PEG6 (hexaethylene glycol).
    • ATFB SE (N-Succinimidyl 4-Azidotetrafluorobenzoate)
      N-Succinimidyl 4-Azidotetrafluorobenzoate (ATFB SE, ATFB-OSu) is a photo-activatable linker used as a versatile labeling agent for investigating biological receptors.
    • Exo-BCN-PNP
      BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.
    • Disuccinimidyl glutarate (DSG)
      Homobifunctional crosslinker with two NHS ester groups at each end of a short 5-atom (7.7 angstrom) spacer.
    • Biotin-PEG4-NHS ester
      PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.
    • 3-Maleimidopropionic acid NHS-ester
      Bifunctional crosslinker with an amine-reactive succinimidyl ester and a thiol-reactive maleimide group.
    • DBCO-PEG6-NHS ester
      A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
    • TCO-PEG4-NHS ester (axial isomer)
      A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.
    • Azidobutyric acid NHS ester
      Activated NHS ester for azido-labeling of peptides and proteins.
    • DBCO-STP ester
      Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.
    • Hexynoic acid STP ester
      Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
    • Alkyne-PEG2-NHS ester
      Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
    • Alkyne-PEG4-NHS ester
      Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
    • Alkyne-PEG3-NHS ester
      Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
    • DBCO-NHS ester
      Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
    • Hexynoic acid NHS ester
      Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.
    • Biotin-XX-NHS ester
      Biotin derivative with long spacer to reduce steric effect when binding amino acids, peptides, or proteins by reacting with primary amines.

Azides

Various non-fluorescent azides for click chemistry. Fluorescent azides are listed under Reactive dyes category.
Group tags Crosslinking, PROTAC, NHS esters, Copper-free click chemistry, Tetrazines, Biotinylation, Maleimides, Carboxylic acids, Azides, Halides, Click chemistry, Protein labeling, Amines
    • Azide-PEG4-maleimide kit
    • 3-Azidopropylamine
      Water-soluble, bifunctional short crosslinker with amino and azide groups.
    • Azide-PEG4-carboxylic acid
      Bifunctional tetraethylene glycol with terminal carboxyl and azido groups.
    • Azide-PEG6-OH
      Water-soluble heterobifunctional crosslinker with a primary hydroxyl group, alkyne-reactive azide group, and a PEG6 hydrophilic linker.
    • Thalidomide-O-PEG2-azide
      Thalidomide-containing building block with PEG2-linker and azide function group for conjugation with alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
    • ATFB SE (N-Succinimidyl 4-Azidotetrafluorobenzoate)
      N-Succinimidyl 4-Azidotetrafluorobenzoate (ATFB SE, ATFB-OSu) is a photo-activatable linker used as a versatile labeling agent for investigating biological receptors.
    • Azide-PEG2-carboxylic acid
      Bifunctional diethylene glycol with terminal carboxyl and azido groups.
    • 3-Azidopropylamine hydrochloride
      A bifunctional short linker with amino and azido groups. A solid, chemically stable hydrochloride form of azidopropylamine. This product is ideal as an azidopropylamine bulk for applications when a large amount of reagent is needed.
    • Azide-PEG3-tetrazine
      A hydrophilic bifunctional linker with azide and tetrazine function groups flanking PEG3 (triethylene glycol) spacer.
    • Biotin-PEG4-azide
      Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
    • Azide-PEG6-NHS ester
      A hydrophilic bifunctional linker with azide and NHS ester function groups flanking PEG6 (hexaethylene glycol).
    • 3-Azidopropanol
      Azidopropanol is a short bifunctional linker compound with azide and hydroxyl functional groups.
    • Azide-PEG2-iodide
      A bifunctional molecule containing hydrophilic PEG2 with azide and iodide groups.
    • Azidobutyric acid NHS ester
      Activated NHS ester for azido-labeling of peptides and proteins.
    • Azide-PEG2-amine
      A diethylene glycol (PEG2) linker with azide and amino groups.
    • Azide-PEG3-carboxylic acid
      Bifunctional triethylene glycol with terminal carboxyl and azido groups.
    • Azide-PEG4-OH
      Azide-PEG4-OH is a bifunctional molecule with an azide group, primary alcohol, and a hydrophilic PEG4 linker in between.
    • Azide-PEG3-OH
      Azide-PEG3-OH is a bifunctional molecule with an azide group, primary alcohol, and a hydrophilic PEG3 linker in between.
    • Azide-PEG3-iodide
      Azide-PEG3-iodide is a bifunctional linker with a highly reactive alkylative halogen functional group and an azido group for click chemistry or Staudinger ligation.
    • Azide-PEG3-chloride
      Azide-PEG3-chloride contains a reactive halogen atom and an azide group for click chemistry reaction. It can also serve as a protected amine group equivalent.
    • Azide-PEG4-amine
      PEG4 amine azide is a bifunctional linker with amine and azide functional groups. It is based on a tetraethyleneglycol core. The length of the PEG4 linker is 1.4 nm.
    • Azide-PEG4-azide
      PEG4 diazide is a homobifunctional linker with two azide groups. It can be used for the synthesis of dimeric molecules with a hydrophilic core by click chemistry.
    • Azide-PEG3-amine
      A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)
    • Azide-PEG3-azide
      Triethylene glycol diazide is a bifunctional crosslinker bearing two azide groups. Suitable for click chemistry.
    • (S,R,S)-AHPC-PEG2-C2-azide
      Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

Alkynes

Various terminal alkynes for сlick сhemistry. Fluorescent dye alkynes are listed under 'Reactive dyes' category.
Group tags Crosslinking, NHS esters, STP esters, Biotinylation, Maleimides, Carboxylic acids, Alkynes, Halides, Hydrazides, Click chemistry, Protein labeling, Amines
    • Pentynoic acid STP ester
      An activated ester for the introduction of alkyne into peptides/proteins and click reaction.
    • Alkyne-PEG3-amine
      Alkyne-PEG3-amine is a medium-length heterobifunctional linker for conjugation.
    • Biotin-PEG4-alkyne
      Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
    • Alkyne-PEG3-maleimide
      Bifunctional spacer with alkyne and maleimide groups for conjugation of biomolecules.
    • Alkyne-PEG2-carboxylic acid
      Bifunctional diethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
    • Alkyne-PEG4-iodide
      Bifunctional reactive PEG4-based crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling and reactive alkyl iodide group.
    • Alkyne-PEG4-carboxylic acid
      Bifunctional tetraethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
    • Hexynoic acid STP ester
      Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
    • Alkyne-PEG2-NHS ester
      Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
    • Alkyne-PEG4-NHS ester
      Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
    • Alkyne-PEG3-NHS ester
      Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
    • Hexynoic acid NHS ester
      Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.
    • Alkyne-PEG3-iodide
      PEG3 with alkyne and iodide functional groups, a reactive and hydrophilic linker for alkylation and click chemistry.
    • Alkyne-PEG2-iodide
      Bifunctional reactive crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling, and reactive alkyl iodide group.
    • Alkyne-PEG2-amine
      Diethyleneglycol (PEG2) based bifunctional linker containing amine and alkyne functional groups.
    • Alkyne-PEG4-maleimide
      Water soluble, heterobifunctional hydrophilic linker with a length of 14 Å, containing maleimide for thiol labeling, and alkyne for click chemistry. An ideal reagent to attach an alkyne moiety to a protein.
    • Alkyne-PEG4-amine
      A bifunctional linker molecule containing both terminal alkyne moiety for click chemistry, and amine group. Contains a long hydrophilic PEG4 arm.
    • Alkyne-PEG3-carboxylic acid
      Bifunctional triethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
    • Alkyne-PEG3-OH
      Alkyne-PEG3-OH is a triethyleneglycol based bifunctional linker with a hydroxyl group and an alkyne fragment.
    • Alkyne hydrazide
      Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
    • Alkyne maleimide
      Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
    • Biotin-PEG2-alkyne
      Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.

Cycloalkynes

Highly reactive cycloalkynes for copper-free click reaction (SPAAC, strain-promoted azide-alkyne cycloaddition).
Group tags Crosslinking, NHS esters, Copper-free click chemistry, STP esters, Cycloalkynes, Maleimides, Cyanine3, Click chemistry, Protein labeling, Amines
    • DBCO-NHS ester
      Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
    • DBCO-STP ester
      Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.
    • Cyanine3-PEG4-BCN (exo)
      Cyanine3-PEG4-BCN is an ethylene glycol separated linker for the azido-modified molecules for copper-free click conjugation.
    • DBCO-amine trifluoroacetate
      Bifunctional linker containing dibenzocyclooctyne (DBCO, ADIBO) for strain-promoted copper-free click reaction (SPAAC) and free amine for the coupling with various electrophilic compounds like activated esters and epoxides.
    • DBCO-PEG6-NHS ester
      A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
    • Exo-BCN-PNP
      BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.
    • DBCO-maleimide
      Bifunctional linker containing a thiol-reactive maleimide group and an azide-reactive dibenzocyclooctyne moiety.

Tetrazines

Non-fluorescent tetrazines for inverse electron demand Diels-Alder reaction (IEDDA) with terminal alkenes and strained olefins, such as trans-cyclooctenes and some cyclooctynes.
Group tags Crosslinking, Copper-free click chemistry, Tetrazines, Biotinylation, Azides, Click chemistry
    • Tetrazine-PEG3-OH
      Tetrazine-PEG3-OH is a mono-reactive triethyleneglycol with a tetrazine group for IEDDA conjugation with strained olefins.
    • Azide-PEG3-tetrazine
      A hydrophilic bifunctional linker with azide and tetrazine function groups flanking PEG3 (triethylene glycol) spacer.
    • Biotin-PEG4-tetrazine
      Biotin tetrazine is a reagent for copper-free click chemistry labeling with biotin, a well-known affinity probe to streptavidin.

Cycloalkenes

Cycloalkenes for copper-free alkene-tetrazine click reaction.
Group tags Crosslinking, NHS esters, Cycloalkenes, Copper-free click chemistry, Protein labeling
    • TCO-PEG4-NHS ester (axial isomer)
      A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.

Amines

Amines for the coupling with various electrophilic compounds like activated esters and epoxides.
Group tags Crosslinking, PROTAC, Copper-free click chemistry, Biotinylation, Cycloalkynes, Carboxylic acids, Azides, Alkynes, Click chemistry, Amines
    • Azide-PEG3-amine
      A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)
    • DBCO-amine trifluoroacetate
      Bifunctional linker containing dibenzocyclooctyne (DBCO, ADIBO) for strain-promoted copper-free click reaction (SPAAC) and free amine for the coupling with various electrophilic compounds like activated esters and epoxides.
    • (S,R,S)-AHPC-PEG2-C2-amine
      Degrader building block containing an E3 ligase ligand with linker and amino group for conjugation with other functionalized linkers and target protein ligands.
    • VHL Ligand 1 dihydrochloride
      VHL Ligand 1 is a building block for synthesizing proteolysis-targeting chimera (PROTAC) molecules.
    • Thalidomide-O-PEG2-amine
      Thalidomide-containing building block with PEG2-linker and amino group for conjugation with other functionalized linkers and target protein ligands.
    • Amine-PEG6-OH
      A hydrophilic hexaethylene glycol derivative with terminal amino and hydroxyl groups.
    • Tetraglycine hydrochloride
      Tetraglycine is an oligopeptide composed of four glycine monomers. It is used as a bifunctional linker with amino and carboxyl groups.
    • 3-Azidopropylamine hydrochloride
      A bifunctional short linker with amino and azido groups. A solid, chemically stable hydrochloride form of azidopropylamine. This product is ideal as an azidopropylamine bulk for applications when a large amount of reagent is needed.
    • Amine-PEG2-carboxylic acid
      Hydrophilic PEG2-linker with a terminal amino group and a carboxyl group.
    • Biotin-PEG4-amine
      Tetraethylene glycol (PEG4) based bifunctional molecule containing biotin and amine functional group.
    • Amine-PEG3-carboxylic acid
      Hydrophilic PEG3-linker with a terminal amino group and a carboxyl group.
    • Azide-PEG4-amine
      PEG4 amine azide is a bifunctional linker with amine and azide functional groups. It is based on a tetraethyleneglycol core. The length of the PEG4 linker is 1.4 nm.
    • Amine-PEG3-OH
      Bifunctional PEG3 derivative with amine and hydroxyl groups.
    • Biotin-PEG2-amine
      Diethylene glycol (PEG2) based bifunctional molecule containing biotin and amine functional group.
    • Biotin-PEG3-amine
      Triethylene glycol (PEG3) based bifunctional molecule containing biotin and amine functional group.
    • Azide-PEG2-amine
      A diethylene glycol (PEG2) linker with azide and amino groups.
    • Amine-PEG4-OH
      A hydrophilic tetraethylene glycol derivative with terminal amino and hydroxyl groups.
    • Alkyne-PEG3-amine
      Alkyne-PEG3-amine is a medium-length heterobifunctional linker for conjugation.
    • Alkyne-PEG2-amine
      Diethyleneglycol (PEG2) based bifunctional linker containing amine and alkyne functional groups.
    • Alkyne-PEG4-amine
      A bifunctional linker molecule containing both terminal alkyne moiety for click chemistry, and amine group. Contains a long hydrophilic PEG4 arm.
    • Amine-PEG4-carboxylic acid
      Hydrophilic PEG4-linker with a terminal amino group and a carboxyl group.

Hydrazides

Hydrazides are carbonyl-reactive reagents for the labeling of aldehydes and ketones.
Group tags Crosslinking, Biotinylation, Azides, Alkynes, Hydrazides, Click chemistry, Protein labeling
    • Alkyne hydrazide
      Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
    • Biotin-X-hydrazide
      Hydrazide biotin reagent with aminocaproic spacer useful for biotinylation of macromolecule reactive carbonyls.
    • Azide-PEG4-hydrazide
      A bifunctional reagent containing the azide group and hydrazide function. It reacts with aldehydes and ketones. The azide group can then be coupled with various alkynes via CuAAC reaction.

Maleimides

Maleimides are thiol-reactive compounds for labeling sulfhydryl (thiol) groups in proteins.
Group tags Crosslinking, NHS esters, Copper-free click chemistry, Biotinylation, Cycloalkynes, Maleimides, ICG (Indocyanine Green), Azides, Alkynes, Click chemistry
    • Azide-PEG4-maleimide kit
    • Alkyne maleimide
      Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
    • Alkyne-PEG4-maleimide
      Water soluble, heterobifunctional hydrophilic linker with a length of 14 Å, containing maleimide for thiol labeling, and alkyne for click chemistry. An ideal reagent to attach an alkyne moiety to a protein.
    • Alkyne-PEG3-maleimide
      Bifunctional spacer with alkyne and maleimide groups for conjugation of biomolecules.
    • 3-Maleimidopropionic acid NHS-ester
      Bifunctional crosslinker with an amine-reactive succinimidyl ester and a thiol-reactive maleimide group.
    • Biotin-X-maleimide
      Thiol-reactive bifunctional linker for attaching biotin to proteins, peptides, and other thiolated molecules.
    • DBCO-maleimide
      Bifunctional linker containing a thiol-reactive maleimide group and an azide-reactive dibenzocyclooctyne moiety.
    • ICG maleimide
      ICG maleimide is a thiol-reactive dye for labeling protein and other thiol-containing molecules.

Thiols

Bifunctional reagents with a thiol (-SH) functional group. Thiols are nucleophilic compounds that participate in many reactions with electrophiles.
Group tags Crosslinking, Thiols
    • Hydroxy-PEG3-thiol
      PEG3 bifunctional linker with thiol and hydroxyl groups. Thiol can coat gold surfaces forming a hydrophilic monolayer.
    • Hydroxy-PEG2-thiol
      Short bifunctional linker with thiol and hydroxyl groups. Thiol can coat gold surfaces forming a hydrophilic monolayer.

Halides

Halogen derivatives with reactive groups for bioconjugation.
Group tags Crosslinking, Biotinylation, Carboxylic acids, Azides, Alkynes, Halides, Click chemistry
    • Iodo-PEG3-carboxylic acid
      A bifunctional compound containing carboxylic acid functional group, and iodide, an active halogen group.
    • Azide-PEG3-chloride
      Azide-PEG3-chloride contains a reactive halogen atom and an azide group for click chemistry reaction. It can also serve as a protected amine group equivalent.
    • Iodo-PEG3-iodide
      Homobifunctional PEG3 based linker with halogen reactive groups is useful for the crosslinking of nucleophiles.
    • Alkyne-PEG2-iodide
      Bifunctional reactive crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling, and reactive alkyl iodide group.
    • Azide-PEG3-iodide
      Azide-PEG3-iodide is a bifunctional linker with a highly reactive alkylative halogen functional group and an azido group for click chemistry or Staudinger ligation.
    • Alkyne-PEG3-iodide
      PEG3 with alkyne and iodide functional groups, a reactive and hydrophilic linker for alkylation and click chemistry.
    • Alkyne-PEG4-iodide
      Bifunctional reactive PEG4-based crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling and reactive alkyl iodide group.
    • Azide-PEG2-iodide
      A bifunctional molecule containing hydrophilic PEG2 with azide and iodide groups.
    • Biotin-PEG4-iodide
      A highly reactive biotinylation reagent that readily and efficiently interacts with various nucleophiles.

Carboxylic acids

Carboxylic acids with reactive groups for the conjugation of different biomolecules.
Group tags Crosslinking, PROTAC, Biotinylation, Carboxylic acids, Azides, Alkynes, Halides, Click chemistry, Amines

Alcohols

Alcohols with reactive groups for the conjugation of different biomolecules.
Group tags Crosslinking, Thiols, Copper-free click chemistry, Tetrazines, Biotinylation, Azides, Alkynes, Click chemistry, Amines
    • Alkyne-PEG3-OH
      Alkyne-PEG3-OH is a triethyleneglycol based bifunctional linker with a hydroxyl group and an alkyne fragment.
    • Tetrazine-PEG3-OH
      Tetrazine-PEG3-OH is a mono-reactive triethyleneglycol with a tetrazine group for IEDDA conjugation with strained olefins.
    • Azide-PEG3-OH
      Azide-PEG3-OH is a bifunctional molecule with an azide group, primary alcohol, and a hydrophilic PEG3 linker in between.
    • Hydroxy-PEG3-thiol
      PEG3 bifunctional linker with thiol and hydroxyl groups. Thiol can coat gold surfaces forming a hydrophilic monolayer.
    • Hydroxy-PEG2-thiol
      Short bifunctional linker with thiol and hydroxyl groups. Thiol can coat gold surfaces forming a hydrophilic monolayer.
    • Azide-PEG4-OH
      Azide-PEG4-OH is a bifunctional molecule with an azide group, primary alcohol, and a hydrophilic PEG4 linker in between.
    • Amine-PEG4-OH
      A hydrophilic tetraethylene glycol derivative with terminal amino and hydroxyl groups.
    • 3-Azidopropanol
      Azidopropanol is a short bifunctional linker compound with azide and hydroxyl functional groups.
    • Amine-PEG3-OH
      Bifunctional PEG3 derivative with amine and hydroxyl groups.
    • Azide-PEG6-OH
      Water-soluble heterobifunctional crosslinker with a primary hydroxyl group, alkyne-reactive azide group, and a PEG6 hydrophilic linker.
    • Amine-PEG6-OH
      A hydrophilic hexaethylene glycol derivative with terminal amino and hydroxyl groups.
    • Biotin-PEG3-OH
      Bifunctional triethyleneglycol linker with biotin and hydroxyl moieties.

Biotin

Biotin derivatives with different spacers for introducing biotin labels into proteins, antibodies, and nucleic acids.
Group tags Crosslinking, NHS esters, Copper-free click chemistry, Tetrazines, Biotinylation, Maleimides, Carboxylic acids, Neuroscience, Azides, Alkynes, Halides, Hydrazides, sulfo-Cyanine3, Microscopy, Click chemistry, sulfo-Cyanine5, Tyramides, Protein labeling, Amines
    • Biotin-PEG3-azide
      Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
    • Biotin-PEG4-azide
      Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
    • Biotin-PEG3-OH
      Bifunctional triethyleneglycol linker with biotin and hydroxyl moieties.
    • Biotin-XX-NHS ester
      Biotin derivative with long spacer to reduce steric effect when binding amino acids, peptides, or proteins by reacting with primary amines.
    • Biotin-X-maleimide
      Thiol-reactive bifunctional linker for attaching biotin to proteins, peptides, and other thiolated molecules.
    • Biotin-PEG4-tetrazine
      Biotin tetrazine is a reagent for copper-free click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
    • Biotin-PEG4-iodide
      A highly reactive biotinylation reagent that readily and efficiently interacts with various nucleophiles.
    • Biotin-PEG4-amine
      Tetraethylene glycol (PEG4) based bifunctional molecule containing biotin and amine functional group.
    • Biotin-PEG2-alkyne
      Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
    • Biotin-PEG4-alkyne
      Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
    • Biotin-PEG4-NHS ester
      PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.
    • Biotin alkyne
      Biotin alkyne is a reactive affinity label which can be attached to biomolecules via click reaction.
    • Biotin-PEG4-carboxylic acid
      Bifunctional tetraethyleneglycol linker with biotin and carboxylic acid moieties.
    • Biocytin hydrochloride
      Lysine derivative of biotin for conjugation with avidin or streptavidin, neuroanatomical tracer.
    • Biotin-cystamine hydrochloride
      Biotin and cystamine conjugate is a cleavable biotinylation reagent.
    • Biotin-X-hydrazide
      Hydrazide biotin reagent with aminocaproic spacer useful for biotinylation of macromolecule reactive carbonyls.
    • sulfo-Cyanine3-PEG3-biotin
      Conjugate of hydrophilic sulfo-Cyanine3 dye with biotin, affinity label for avidin/streptavidin.
    • Biotin-PEG3-amine
      Triethylene glycol (PEG3) based bifunctional molecule containing biotin and amine functional group.
    • Biotin-PEG2-azide
      Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
    • Biotin-X-NHS ester
      Biotin derivative with C6-spacer to reduce steric effect when binding amino acids, peptides, or proteins by reacting with primary amines.
    • sulfo-Cyanine5-PEG3-biotin
      Biotin conjugate of the far-red fluorescent sulfo-Cyanine5 dye.
    • Biotinyl tyramide
      Biotin derivative of tyramide for amplification and subsequent signal detection with a labeled streptavidin conjugate.

Homobifunctional reagents

Homobifunctional crosslinkers with identical reactive groups at opposite ends of the spacer for intramolecular crosslinks and chemical crosslinking of macromolecular chains.
Group tags Crosslinking, NHS esters, Carboxylic acids, Azides, Halides, Click chemistry
    • Azide-PEG3-azide
      Triethylene glycol diazide is a bifunctional crosslinker bearing two azide groups. Suitable for click chemistry.
    • PEG3-dicarboxylic acid
      PEG3-dicarboxylic acid is a bifunctional linker carrying two carboxy groups. It contains a polyethyleneglycol-3 linker between the carboxyls.
    • Azide-PEG4-azide
      PEG4 diazide is a homobifunctional linker with two azide groups. It can be used for the synthesis of dimeric molecules with a hydrophilic core by click chemistry.
    • Iodo-PEG3-iodide
      Homobifunctional PEG3 based linker with halogen reactive groups is useful for the crosslinking of nucleophiles.
    • Disuccinimidyl glutarate (DSG)
      Homobifunctional crosslinker with two NHS ester groups at each end of a short 5-atom (7.7 angstrom) spacer.

Click chemistry ligands and catalysts

Auxiliary reagents for click chemistry: catalysts, buffers, and ligands for copper-catalyzed click reaction (CuAAC).
Group tags Click chemistry
    • Copper(II)-TBTA complex
      A catalyst for click reaction. A stable copper(II) complex which must be converted to monovalent copper(I) in situ using reducing agents. The complex can be used to prepare a reaction buffer of any composition.
    • Ascorbic acid
      Ascorbic acid is a reducing agent converting copper(II) into a monovalent form that catalyzes the click reaction.
    • Copper(II)-TВTA catalytic buffer, 1.5x
      Ready-to-use catalytic buffer containing сopper(II) and TBTA ligand. It is suitable for click chemistry modification of nucleic acids and small molecules.
    • THPTA ligand
      THPTA is a water-soluble ligand for Cu(I)-catalyzed click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.
    • TBTA ligand
      TBTA is one of the most widely used water-insoluble ligands for copper-catalyzed azide-alkyne cycloadditions (CuAAC).
    • Copper(II)-THPTA catalytic buffer, 1.5x
      Ready-to-use catalytic buffer containing сopper(II) and water-soluble THPTA ligand. It is suitable for click chemistry modification of proteins.
    • BTTAA ligand
      BTTAA is the newest generation of water-soluble ligands for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) that dramatically accelerates reaction rates and suppresses cell cytotoxicity.
    • Copper(II)-BTTAA complex
      A catalyst for copper-catalyzed click reactions in aqueous media. A stable сopper(II) complex with BTTAA which must be converted to copper(I) using reducing agents. The complex can be used to prepare a reaction buffer of any composition.

Auxiliary reagents for bioconjugation

Auxiliary reagents, various buffers, and solvents for labeling and conjugation.
Group tags Click chemistry
Short link - lumiprobe.com/sh/c/l
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