Disuccinimidyl glutarate (DSG)

Cat. # Quantity Price Lead time
4018-100mg 100 mg $95 in stock
4018-1g 1 g $410 in stock
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Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinker that contains two N-hydroxysuccinimide (NHS) ester groups at each end of a short 5-atom (7.7 angstrom) spacer.

DSG is a membrane-permeable and non-cleavable crosslinker, allowing for intracellular labeling of peptides and proteins. NHS esters react with amines of lysine residues and N-termini of peptides and proteins, forming a covalent amide bond and releasing the NHS group. DSG is commonly used to pair radiolabelled ligands to cell surface receptors and determine DNA-protein binding interactions in ChIP assays. DSG labeling is often combined with formaldehyde fixation to improve the detection of DNA-protein complexes.

DSG is water-insoluble and must be dissolved in an organic solvent, such as DMSO or DMF, before being added to aqueous solutions.

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General properties

Appearance: off-white powder
Molecular weight: 326.26
CAS number: 79642-50-5
Molecular formula: C13H14N2O8
IUPAC name: Bis(2,5-dioxopyrrolidin-1-yl) Pentanedioate
Solubility: DMF, DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
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