DMSO is a polar aprotic solvent widely used in bioconjugation. This solvent can be considered as very important co-solvent for Click reactions to label various objects with poorly water-soluble fluorescent dyes. DMSO is also recommended as an auxiliary solvent in the reaction mixture when a hydrophobic label is used for protein labeling, or when a label molecule needs to be aliquoted before the reaction.
Coumarin 343 is a blue emitting fluorophore that can serve as a FRET donor for fluorescein (FAM). This azide derivative can be conjugated with alkynes by Click chemistry. An extended linker arm between the fluorophore and the azide group enhances solubility, and provides spatial separation between the dye and the biomolecule.
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