SynaptoProbe® Green

Neuroscience Cell membrane Synaptic vesicles Microscopy

Cat. #	Quantity	Price	Lead time
3762-100ug	100 ug	–	in stock
3762-1mg	1 mg	$112	in stock
3762-5mg	5 mg	$379	in stock

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SynaptoProbe® Green is an analog of FM^®1-43, a widely used green fluorescent dye for studying synaptic activity in the synapses or neuromuscular junctions by staining synaptic vesicles.

This water-soluble and non-toxic to cells dye is nonfluorescent in an aqueous medium but becomes highly fluorescent after embedding into the outer leaflet of the cell membrane. When a neuron actively releases neurotransmitters, the dye becomes internalized within the recycled synaptic vesicles and stains the nerve terminals.

SynaptoProbe® Green can be used to visualize synaptic vesicles and their exocytosis and endocytosis in living neurons, identify actively firing neurons, and investigate the mechanisms of activity-dependent vesicle cycling. It is also helpful for the visualization of shear stress-induced plasma membrane damage in fibroblasts.

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Absorption and emission spectra of SynaptoProbe Green

General properties

Appearance:	light red solid
Molecular weight:	705.55
CAS number:	149838-22-2 (dibromide)
Molecular formula:	C₃₀H₄₉I₂N₃
IUPAC name:	N-(3-Triethylammoniumpropyl)-4-(4-(Dibutylamino) Styryl) Pyridinium Diiodide
Solubility:	good in water
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

Spectral properties

Excitation/absorption maximum, nm:	492
ε, L⋅mol⁻¹⋅cm⁻¹:	55800
Emission maximum, nm:	594

FM® is the trademark of Molecular Probes™

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.