Alkyne maleimide

Cat. # Quantity Price Lead time
41780 25 mg $95 in stock
51780 50 mg $175 in stock
61780 100 mg $200 in stock
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Alkyne maleimide is a bifunctional linker reagent which allows to attach terminal alkyne to various thiol-containing molecules, such as proteins containing cysteine residues. The alkyne moiety can be then conjugated with various azides via copper-catalyzed сlick chemistry reaction.

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General properties

Appearance: colorless solid
Mass spec M+ increment: 234.1
Molecular weight: 234.25
Molecular formula: C12H14N2O3
Solubility: good in DMSO, DMF, alcohols, limited in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Product citations

  1. Hulce, K.R.; Jaishankar, P.; Lee, G.M.; Bohn, M.-F.; Connelly, E.J.; Wucherer, K.; Ongpipattanakul, C.; Volk, R.F.; Chuo, S.-W.; Arkin, M.R.; Renslo, A.R.; Craik, C.S. Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine. Cell Chemical Biology, 2022, 29(5), 785-798.e19. doi: 10.1016/j.chembiol.2022.03.007
  2. Zanon, P.R.A.; Yu, F.; Musacchio, P.; Lewald, L.; Zollo, M.; Krauskopf, K.; Mrdović, D.; Raunft, P.; Maher, T.E.; Cigler, M.; Chang, C.; Lang, K.; Toste, F.D.; Nesvizhskii, A.I.; Hacker, S.M. Profiling the proteome-wide selectivity of diverse electrophiles. ChemRxiv, 2021, preprint. doi: 10.33774/chemrxiv-2021-w7rss-v2
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