Alkyne-PEG3-COOH

Cat. # Quantity Price Lead time
1743-1g 1 g $490.00 in stock
1743-5g 5 g $980.00 in stock
1743-25g 25 g please inquire in stock

Alkyne-PEG3-COOH is a bifunctional triethyleneglycol derivative bearing a carboxy group, and an alkyne moiety. The former can be activated with peptide coupling reagents like PyBOP or carbodiimides like EDC to form a stable amide linkage with amines. The alkyne group can be coupled with azides in a CuAAc reaction.

PEGs are hydrophilic linkers that are useful in the synthesis of water soluble conjugates.

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Azide-PEG3-Amine

A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)

General properties

Appearance: colorless to yellow oil
Molecular weight: 246.26
CAS number: 1415800-32-6
Molecular formula: C11H18O6
IUPAC name: 3,6,9,12-tetraoxapentadecyn-15-oic acid
Solubility: good in most organic solvents and water
Quality control: NMR 1H, GC-MS (95%, as Me ester)
Storage conditions: Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications

Product citations

  1. Petrov, R.A.; Mefedova, S.R.; Yamansarov, E.Y.; Maklakova, S.Y.; Grishin, D.A.; Lopatukhina, E.V.; Burenina, O.Y.; Lopukhov, A.V.; Kovalev, S.V.; Timchenko, Y.V.; Ondar, E.E.; Ivanenkov, Y.A.; Evteev, S.A.; Vaneev, A.N.; Timoshenko, R.V.; Klyachko, N.L.; Erofeev, A.S.; Gorelkin, P.V.; Beloglazkina, E.K.; Majouga, A.G. New Small-Molecule Glycoconjugates of Docetaxel and GalNAc for Targeted Delivery to Hepatocellular Carcinoma. Molecular Pharmaceutics, 2021, 18(1), 461–468. doi: 10.1021/acs.molpharmaceut.0c00980
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