Cyanine5 carboxylic acid
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 13090 | 1 mg | $110.00 | in stock | |
| 23090 | 5 mg | $210.00 | in stock | |
| 43090 | 25 mg |
$410.00
|
in stock | |
| 53090 | 50 mg |
$695.00
|
in stock | |
| 63090 | 100 mg |
$1190.00
|
in stock |
Non-activated carboxylic acid, an analog of Cy5® free carboxylic acid. Contains Cyanine5 fluorophore.
This dye has limited water solubility, but can be dissolved in mixtures of water with organic phase (DMF, DMSO, alcohols) to obtain useful concentrations of the material in solution. Water-soluble version is available.
This molecule can be considered non-reactive dye for the use in control samples, and for instrument calibration. For coupling with amines and protein labeling, consider using Cyanine5 NHS ester, or water-soluble sulfo-Cyanine5 NHS ester.
Cyanine5 absorbance and emission spectra
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General properties
| Appearance: | dark blue powder |
| Molecular weight: | 519.12 |
| CAS number: | 1032678-07-1 (chloride), 195867-59-5 (inner salt), 766503-38-2 (without anion) |
| Molecular formula: | C32H39ClN2O2 |
| IUPAC name: | 3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1,3,3-trimethyl-, chloride |
| Solubility: | soluble in organic solvents (DMF, DMSO, dichloromethane), very poorly soluble in water (0.25 mM, 130 mg/L) |
| Quality control: | NMR 1H, HPLC-MS (95%) |
| Storage conditions: | Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation/absorption maximum, nm: | 646 |
| ε, L⋅mol−1⋅cm−1: | 250000 |
| Emission maximum, nm: | 662 |
| Fluorescence quantum yield: | 0.2 |
| CF260: | 0.03 |
| CF280: | 0.04 |
Product citations
- Petrov, R.A.; Mefedova, S.R.; Yamansarov, E.Y.; Maklakova, S.Y.; Grishin, D.A.; Lopatukhina, E.V.; Burenina, O.Y.; Lopukhov, A.V.; Kovalev, S.V.; Timchenko, Y.V.; Ondar, E.E.; Ivanenkov, Y.A.; Evteev, S.A.; Vaneev, A.N.; Timoshenko, R.V.; Klyachko, N.L.; Erofeev, A.S.; Gorelkin, P.V.; Beloglazkina, E.K.; Majouga, A.G. New Small-Molecule Glycoconjugates of Docetaxel and GalNAc for Targeted Delivery to Hepatocellular Carcinoma. Molecular Pharmaceutics, 2021, 18(1), 461–468. doi: 10.1021/acs.molpharmaceut.0c00980
- Wang, Y.; Goun, A.; Laforge, F.; Quine, Z.; Rabitz, H. A key bidirectional switching issue in optogenetics emulated with laser dyes to illustrate its mitigation using nonlinear optical tools. Applied Physics Letters, 2021, 118(2), 024101. doi: 10.1063/5.0035183
- Pfister, J.; Lichius, A.; Summer, D.; Haas, H.; Kanagasundaram, T.; Kopka, K.; Decristoforo, C. Live-cell imaging with Aspergillus fumigatus-specific fluorescent siderophore conjugates. Scientific Reports, 2020, 10, 15519. doi: 10.1038/s41598-020-72452-2
- Reshitko, G.S.; Yamansarov, E.Y.; Evteev, S.A.; Lopatukhina, E.V.; Shkil', D.O.; Saltykova, I.V.; Lopukhov, A.V.; Kovalev, S.V.; Lobov, A.N.; Kislyakov, I.V.; Burenina, O.Y.; Klyachko, N.L.; Garanina, A.S.; Dontsova, O.A.; Ivanenkov, Y.A.; Erofeev, A.S.; Gorelkin, P.V.; Beloglazkina, E.K.; Majouga, A.G. Synthesis and Evaluation of New Trivalent Ligands for Hepatocyte Targeting via the Asialoglycoprotein Receptor. Bioconjugate Chemistry, 2020, 31(5), 1313–1319. doi: 10.1021/acs.bioconjchem.0c00202
Cy® is a trademark of GE Healthcare.
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