Cyanine5 carboxylic acid

Cat. # Quantity Price Lead time
13090 1 mg $110.00 in stock
23090 5 mg $210.00 in stock
43090 25 mg $410.00 in stock
53090 50 mg $695.00 in stock
63090 100 mg $1190.00 in stock

Non-activated carboxylic acid, an analog of Cy5® free carboxylic acid. Contains Cyanine5 fluorophore.

This dye has limited water solubility, but can be dissolved in mixtures of water with organic phase (DMF, DMSO, alcohols) to obtain useful concentrations of the material in solution. Water-soluble version is available.

This molecule can be considered non-reactive dye for the use in control samples, and for instrument calibration. For coupling with amines and protein labeling, consider using Cyanine5 NHS ester, or water-soluble sulfo-Cyanine5 NHS ester.

Cyanine5 absorbance and emission spectra

Cyanine5 absorbance and emission spectra

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Cyanine3 amine

Cyanine3 is an fluorophore with free amino group (amino-dye). It can be conjugated with NHS esters, carboxy groups (after activation), and epoxides.

Sulfo-Cyanine7 carboxylic acid

Sulfo-Cy7 carboxylic acid is a non-reactive fluorescent dye which can be used as a NIR (near infrared) marker.

Sulfo-Cyanine5 NHS ester

Water-soluble Cyanine 5 succinimide ester.

General properties

Appearance: dark blue powder
Molecular weight: 519.12
CAS number: 1032678-07-1 (chloride), 195867-59-5 (inner salt), 766503-38-2 (without anion)
Molecular formula: C32H39ClN2O2
IUPAC name: 3H-​Indolium, 2-​[5-​[1-​(5-​carboxypentyl)​-​1,​3-​dihydro-​3,​3-​dimethyl-​2H-​indol-​2-​ylidene]​-​1,​3-​pentadien-​1-​yl]​-​1,​3,​3-​trimethyl-​, chloride
Solubility: soluble in organic solvents (DMF, DMSO, dichloromethane), very poorly soluble in water (0.25 mM, 130 mg/L)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 646
ε, L⋅mol−1⋅cm−1: 250000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.2
CF260: 0.03
CF280: 0.04

Product citations

  1. Wang, Y.; Goun, A.; Laforge, F.; Quine, Z.; Rabitz, H. A key bidirectional switching issue in optogenetics emulated with laser dyes to illustrate its mitigation using nonlinear optical tools. Applied Physics Letters, 2021, 118(2), 024101. doi: 10.1063/5.0035183
  2. Pfister, J.; Lichius, A.; Summer, D.; Haas, H.; Kanagasundaram, T.; Kopka, K.; Decristoforo, C. Live-cell imaging with Aspergillus fumigatus-specific fluorescent siderophore conjugates. Scientific Reports, 2020, 10, 15519. doi: 10.1038/s41598-020-72452-2
  3. Reshitko, G.S.; Yamansarov, E.Y.; Evteev, S.A.; Lopatukhina, E.V.; Shkil', D.O.; Saltykova, I.V.; Lopukhov, A.V.; Kovalev, S.V.; Lobov, A.N.; Kislyakov, I.V.; Burenina, O.Y.; Klyachko, N.L.; Garanina, A.S.; Dontsova, O.A.; Ivanenkov, Y.A.; Erofeev, A.S.; Gorelkin, P.V.; Beloglazkina, E.K.; Majouga, A.G. Synthesis and Evaluation of New Trivalent Ligands for Hepatocyte Targeting via the Asialoglycoprotein Receptor. Bioconjugate Chemistry, 2020, 31(5), 1313–1319. doi: 10.1021/acs.bioconjchem.0c00202
  4. Martínez-Jothar, L.; Barendrecht, A.D.; de Graaff, A.M.; Oliveira, S.; van Nostrum, C.F.; Schiffelers, R.M.; Hennink, W.E.; Fens, M.H.A.M. Endothelial Cell Targeting by cRGD-Functionalized Polymeric Nanoparticles under Static and Flow Conditions. Nanomaterials, 2020, 10(7), 1353. doi: 10.3390/nano10071353
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