Cyanine5.5 maleimide

Cyanine5.5 Maleimides Microscopy
Cat. # Quantity Price Lead time
17080 1 mg $110.00 in stock
27080 5 mg $210.00 in stock
47080 25 mg $410.00 in stock
57080 50 mg $695.00 in stock
67080 100 mg $1190.00 in stock
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Cyanine5.5 maleimide is a thiol reactive dye which is capable of selective labeling of sulfhydryl groups in proteins, an analog of Cy5.5® maleimide.

Near infrared emission of Cyanine5.5 makes this dye suitable for bioimaging applications.

Cyanine5.5 can replace Cy5.5®, Alexa Fluor 680, and DyLight 680.

Cy5.5 maleimide structure
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Cy5.5 absorbance and emission spectra

Cy5.5 absorbance and emission spectra

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General properties

Appearance: dark blue powder
Molecular weight: 741.36
CAS number: 1594414-90-0; 1593644-50-8; 1854918-28-7
Molecular formula: C46H49ClN4O3
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download

Spectral properties

Excitation maximum, nm: 684
ε, L⋅mol−1⋅cm−1: 209000
Emission maximum, nm: 710
Fluorescence quantum yield: 0.2
CF260: 0.07
CF280: 0.03

Product citations

  1. Chung, S.W.; Choi, J.U.; Cho, Y.S.; Kim, H.R.; Won, T.H.; Dimitrion, P.; Jeon, O.-C.; Kim, S.W.; Kim, I.-S.; Kim, S.Y.; Byun, Y. Self-Triggered Apoptosis Enzyme Prodrug Therapy (STAEPT): Enhancing Targeted Therapies via Recurrent Bystander Killing Effect by Exploiting Caspase-Cleavable Linker. Advanced Science, in press. doi: 10.1002/advs.201800368
  2. Cai, H.; Wang, X.; Zhang, H.; Sun, L.; Pan, D.; Gong, Q.; Gu, Z.; Luo, K. Enzyme-sensitive biodegradable and multifunctional polymeric conjugate as theranostic nanomedicine. Applied Materials Today, 2018, 11, 207–218. doi: 10.1016/j.apmt.2018.02.003
  3. Matsuoka, D.; Watanabe, H.; Shimizu, Y.; Kimura, H.; Yagi, Y.; Kawai, R.; Ono, M.; Saji, H. Structure–activity relationships of succinimidyl-Cys-C (O)-Glu derivatives with different near-infrared fluorophores as optical imaging probes for prostate-specific membrane antigen. Bioorganic & Medicinal Chemistry, 2018, 26(9), 2291–2301. doi: 10.1016/j.bmc.2018.03.015
  4. Zhang, C.; Moonshi, S.S.; Han, Y.; Puttick, S.; Peng, H.; Magoling, B.J.A.; Reid, J.C.; Bernardi, S.; Searles, D.J.; Král, P.; Whittaker, A.K. PFPE-Based Polymeric 19F MRI Agents: A New Class of Contrast Agents with Outstanding Sensitivity. Macromolecules, 2017, 50(15), 5953–5963. doi: 10.1021/acs.macromol.7b01285
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Cy® is a trademark of GE Healthcare.
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