Cyanine5.5 maleimide

Cat. # Quantity Price Lead time
17080 1 mg $110.00 in stock
27080 5 mg $210.00 in stock
47080 25 mg $410.00 in stock
57080 50 mg $695.00 in stock
67080 100 mg $1190.00 in stock

Cyanine5.5 maleimide is a thiol reactive dye which is capable of selective labeling of sulfhydryl groups in proteins, an analog of Cy5.5® maleimide.

Near infrared emission of Cyanine5.5 makes this dye suitable for bioimaging applications.

Cyanine5.5 can replace Cy5.5®, Alexa Fluor 680, and DyLight 680.

Cy5.5 absorbance and emission spectra

Cy5.5 absorbance and emission spectra

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General properties

Appearance: dark blue powder
Molecular weight: 741.36
CAS number: 1594414-90-0, 1854918-28-7 (without anion), 1593644-50-8 (chloride)
Molecular formula: C46H49ClN4O3
IUPAC name: 1H-​Benz[e]​indolium, 2-​[5-​[3-​[6-​[[2-​(2,​5-​dihydro-​2,​5-​dioxo-​1H-​pyrrol-​1-​yl)​ethyl]​amino]​-​6-​oxohexyl]​-​1,​3-​dihydro-​1,​1-​dimethyl-​2H-​benz[e]​indol-​2-​ylidene]​-​1,​3-​pentadien-​1-​yl]​-​1,​1,​3-​trimethyl-
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 684
ε, L⋅mol−1⋅cm−1: 209000
Emission maximum, nm: 710
Fluorescence quantum yield: 0.2
CF260: 0.07
CF280: 0.03

Product citations

  1. Guo, S.; Xiao, X.; Wang, X.; Luo, Q.; Zhu, H.; Zhang, H.; Li, H.; Gong, Q.; Luo, K. Reductive microenvironment responsive gadolinium-based polymers as potential safe MRI contrast agents. Biomaterials Science, in press. doi: 10.1039/c8bm01103f
  2. Galstyan, A.; Chiechi, A.; Korman, A.J.; Sun, T.; Isreal, L.L.; Braubach, O.; Patil, R.; Shatalova, E.; Ljubimov, V.A.; Markman, J.; Grodzinski, Z.; Black, K.L.; Penichet, M.L.; Holler, E.; Ljubimov, A.V.; Ding, H.; Ljubimova, J.Y. Nano immunoconjugates crossing blood-brain barrier activate local brain tumor immune system for glioma treatment. bioRxiv, preprint. doi: 10.1101/466508
  3. Vishnu Vardhan, G.P.; Hema, M.; Sushmitha, C.; Savithri, H.S.; Natraj, U.; Murthy, M.R.N. Development of sesbania mosaic virus nanoparticles for imaging. Archives of Virology, 2019, 164(2), 497–507. doi: 10.1007/s00705-018-4097-y
  4. Zhang, C.; Moonshi, S.S.; Wang, W.; Ta, H.T.; Han, Y.; Han, F.Y.; Peng, H.; Král, P.; Rolfe, B.E.; Gooding, J.J.; Gaus, K.; Whittaker, A.K. High F-Content Perfluoropolyether-Based Nanoparticles for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging. ACS Nano, 2018, 12(9), 9162–9176. doi: 10.1021/acsnano.8b03726
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