Cyanine5.5 maleimide

Cat. # Quantity Price Lead time
17080 1 mg $110.00 5 days
27080 5 mg $210.00 in stock
47080 25 mg $410.00 in stock
57080 50 mg $695.00 in stock
67080 100 mg $1190.00 in stock

Cyanine5.5 maleimide is a thiol reactive dye which is capable of selective labeling of sulfhydryl groups in proteins, an analog of Cy5.5® maleimide.

Near infrared emission of Cyanine5.5 makes this dye suitable for bioimaging applications.

Cyanine5.5 can replace Cy5.5®, Alexa Fluor 680, and DyLight 680.

Cy5.5 absorbance and emission spectra

Cy5.5 absorbance and emission spectra

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General properties

Appearance: dark blue powder
Molecular weight: 741.36
CAS number: 1594414-90-0; 1593644-50-8; 1854918-28-7
Molecular formula: C46H49ClN4O3
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download

Spectral properties

Excitation maximum, nm: 684
ε, L⋅mol−1⋅cm−1: 209000
Emission maximum, nm: 710
Fluorescence quantum yield: 0.2
CF260: 0.07
CF280: 0.03

Product citations

  1. Zhang, C.; Moonshi, S.S.; Han, Y.; Puttick, S.; Peng, H.; Magoling, B.J.A.; Reid, J.C.; Bernardi, S.; Searles, D.J.; Král, P.; Whittaker, A.K. PFPE-Based Polymeric 19F MRI Agents: A New Class of Contrast Agents with Outstanding Sensitivity. Macromolecules, 2017, 50(15), 5953–5963. doi: 10.1021/acs.macromol.7b01285
  2. Masarapu, H.; Patel, B.K.; Chariou, P.L.; Hu, H.; Gulati, N.M.; Carpenter, B.L.; Ghiladi, R.A.; Shukla, S.; Steinmetz, N.F. Physalis Mottle Virus-Like Particles as Nanocarriers for Imaging Reagents and Drugs. Biomacromolecules, 2017, 18(12), 4141–4153. doi: 10.1021/acs.biomac.7b01196
  3. Wilks, M.Q.; Normandin, M.D.; Yuan, H.; Cho, H.; Guo, Y.; Herisson, F.; Ayata, C.; Wooten, D.W.; El Fakhri, G.; Josephson, L. Imaging PEG-Like Nanoprobes in Tumor, Transient Ischemia, and Inflammatory Disease Models. Bioconjugate Chemistry, 2015, 26(6), 1061–1069. doi: 10.1021/acs.bioconjchem.5b00213
  4. Cai, H.; Singh, A.N.; Sun, X.; Peng, F. Synthesis and Characterization of Her2-NLP Peptide Conjugates Targeting Circulating Breast Cancer Cells: Cellular Uptake and Localization by Fluorescent Microscopic Imaging. Journal of Fluorescence, 2015, 25(1), 113–117. doi: 10.1007/s10895-014-1486-9
  5. Graen, T.M.D.; Hoefling, M.; Grubmüller, H. AMBER-DYES: Characterization of Charge Fluctuations and Force Field Parameterization of Fluorescent Dyes for Molecular Dynamics Simulations. Journal of Chemical Theory and Computation, 2014, 10(12), 5505-5512. doi: 10.1021/ct500869p
  6. Park, S.; Kim, Y.-J.; Jon, S. A high-affinity peptide for nicotinic acetylcholine receptor-α1 and its potential use in pulmonary drug delivery. Journal of Controlled Release, 2014, 192, 141-147. doi: 10.1016/j.jconrel.2014.07.006
  7. Wang, X.; Yang, Y.; Jia, H.; Jia, W.; Miller, S.; Bowman, B.; Feng, J.; Zhan, F. Peptide decoration of nanovehicles to achieve active targeting and pathology-responsive cellular uptake for bone metastasis chemotherapy. Biomaterials Science, 2014, 2(7), 961-971. doi: 10.1039/c4bm00020j
  8. Fan, H.; Zhang, I.; Chen, X.; Zhang, L.; Wang, H.; Da Fonseca, A.; Manuel, E.R.; Diamond, D.J.; Raubitschek, A.; Badie, B. Intracerebral CpG Immunotherapy with Carbon Nanotubes Abrogates Growth of Subcutaneous Melanomas in Mice. Clinical Cancer Research, 2012, 18(20), 5628-5638. doi: 10.1158/1078-0432.ccr-12-1911
  9. Zhao, D.; Alizadeh, D.; Zhang, L.; Liu, W.; Farrukh, O.; Manuel, E.; Diamond, D.J.; Badie, B. Carbon Nanotubes Enhance CpG Uptake and Potentiate Antiglioma Immunity. Clinical Cancer Research, 2011, 17(4), 771–782. doi: 10.1158/1078-0432.ccr-10-2444
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