Cyanine7.5 azide

Azides Cyanine7.5 Click chemistry Near infrared (NIR) imaging
Cat. # Quantity Price Lead time
16030 100 uL, 10 mM/DMSO
– 
in stock
36030 500 uL, 10 mM/DMSO
$199
 in stock
46030 1 mL, 10 mM/DMSO
$495
 in stock
A6030 1 mg
– 
in stock
B6030 5 mg
$199
 in stock
C6030 10 mg
$297
 in stock
D6030 25 mg
$495
 in stock
E6030 50 mg
$895
 in stock
F6030 100 mg
$1490
 in stock
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Cyanine7.5 is a NIR dye with long-wave infrared fluorescence. This derivative is azide for click chemistry.

Can be used for the construction of various labeled biomolecules containing Cyanine7.5, near-infrared fluorescent dye, and an improved analog of Cy7.5®. These conjugates can take advantage of NIR tissue transparency when used for in vivo imaging. This fluorophore is also useful for other fluorescent applications, especially requiring low fluorescent background.

Azide is available as a DMSO solution, ready for general click chemistry labeling protocol, or in solid form for custom labeling applications.

Structure features a rigid bridged polymethine chain to increase quantum yield by 20%, allowing for a brighter signal.

Cyanine7.5 azide, azide stock solution for click chemistry (10 mM in DMSO), 36030
Cyanine7.5 azide, azide stock solution for click chemistry (10 mM in DMSO), 36030
Cyanine7.5 azide, azide stock solution for click chemistry (10 mM in DMSO), 36030
Cyanine7.5 azide, E6030
Cyanine7.5 azide, E6030
Cyanine7.5 azide, E6030
Cyanine7.5 azide structure
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Cyanine7.5 absorbance and emission spectra

Cyanine7.5 absorbance and emission spectra

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General properties

Appearance: green powder / solution
Molecular weight: 767.44
CAS number: 1628790-36-2; 1628897-78-8 (without anion)
Molecular formula: C48H55ClN6O
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation/absorption maximum, nm: 788
ε, L⋅mol−1⋅cm−1: 223000
Emission maximum, nm: 808
Fluorescence quantum yield: 0.10

Product citations

  1. Hellyer, S.D.; Aggarwal, S.; Chen, A.N.; Leach, K.; Lapinsky, D.J.; Gregory, K.J. Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes. ACS Chemical Neuroscience, 2020, 11(11), 1597–1609. doi: 10.1021/acschemneuro.0c00009
  2. Retout, M.; Brunetti, E.; Valkenier, H.; Bruylants, G. Limits of thiol chemistry revealed by quantitative analysis of mixed layers of thiolated-PEG ligands grafted onto gold nanoparticles. Journal of Colloid and Interface Science, 2019, 557, 807–815. doi: 10.1016/j.jcis.2019.09.047
  3. Pearce, H.A.; Qian, H.; Connell, T.U.; Huang, D.; Gottstein, C.; Donnelly, P.S.; Peter, K.; Gregorevic, P.; Hagemeyer, C.E. Site-specific glycation and chemo-enzymatic antibody sortagging for the retargeting of rAAV6 to inflamed endothelium. Molecular Therapy - Methods & Clinical Development, 2019, 14, 261–269. doi: 10.1016/j.omtm.2019.07.003
  4. Kong, J.-N.; Zhu, Z.; Itokazu, Y.; Wang, G.; Dinkins, M.B.; Zhong, L.; Lin, H.-P.; Elsherbini, A.; Leanhart, S.; Jiang, X.; Qin, H.; Zhi, W.; Spassieva, S.D.; Bieberich, E. Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes. Journal of Lipid Research, 2018, 59(3), 488–506. doi: 10.1194/jlr.M081877
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Cy® is a trademark of GE Healthcare.
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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