Sulfo-Cyanine5 NHS ester

Cat. # Quantity Price Lead time
13320 1 mg $110.00 in stock
23320 5 mg $290.00 in stock
43320 25 mg $690.00 in stock
53320 50 mg $1270.00 in stock
63320 100 mg $1990.00 in stock

Water soluble Cyanine 5 succinimidyl ester (SE), an equivalent of Cy5® NHS ester, for the labeling of various amine-containing molecules in aqueous phase without use of any organic co-solvent. This product is therefore particularly useful for the labeling of proteins which denature in the presence of organic co-solvents, as well as for proteins with low solubility.

Sulfo-Cyanine 5 is an analog of Cy5®, one of the most popular fluorophores which is compatible with various equipment such as plate readers, microscopes, and imagers.

This dye is highly hydrophilic and water-soluble. A non-sulfonated analog is also available.

Can be used as a replacement for Cy5®, Alexa Fluor 647, DyLight 649 for all applications.

Sulfo-Cyanine 5 absorbance and emission spectra

Sulfo-Cyanine 5 absorbance and emission spectra

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General properties

Appearance: dark blue powder
Molecular weight: 777.95
Molecular formula: C36H40N3KO10S2
Solubility: very good in water, good in DMF and DMSO
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 646
ε, L⋅mol−1⋅cm−1: 271000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.28
CF260: 0.04
CF280: 0.04

Product citations

  1. Le, D.H.T.; Méndez-López, E.; Wang, C.; Commandeur, U.; Aranda, M.A.; Steinmetz, N.F. Biodistribution of Filamentous Plant Virus Nanoparticles: Pepino Mosaic Virus versus Potato Virus X. Biomacromolecules, 2019, 20(1), 469–477. doi: 10.1021/acs.biomac.8b01365
  2. Pirutin, S.K.; Efremova, M.V.; Yusipovich, A.I.; Turovetskii, V.B.; Maksimov, G.V.; Druzhko, A.B.; Mazhuga, A.G. Visualization and Cytotoxicity of Fluorescence-Labeled Dimeric Magnetite-Gold Nanoparticles Conjugated with Prostate-Specific Membrane Antigen in Mouse Macrophages. Bulletin of Experimental Biology and Medicine, 2019, 166(3), 386–389. doi: 10.1007/s10517-019-04356-9
  3. Lalonde, T.; Shepherd, T.G.; Dhanvantari, S.; Luyt, L.G. Stapled ghrelin peptides as fluorescent imaging probes. Peptide Science, 2019, 111(1), e24055. doi: 10.1002/pep2.24055
  4. Kluender, E.J.; Hedrick, J.L.; Brown, K.A.; Rao, R.; Meckes, B.; Du, J.S.; Moreau, L.M.; Maruyama, B.; Mirkin, C.A. Catalyst discovery through megalibraries of nanomaterials. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(1), 40–45. doi: 10.1073/pnas.1815358116
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