Pentynoic acid STP ester

Cat. # Quantity Price Lead time
30720 10 mg $110.00 in stock
40720 25 mg $210.00 in stock
50720 50 mg $410.00 5 days
60720 100 mg $695.00 8 days

This water soluble alkyne activated ester reagent is used for the attachment of alkyne group to variois biomolecules such as proteins, and peptides. Amino-DNA, and other amines can be used as well. Since natural proteins do not contain alkynes, but almost always contain amines (lysines), this molecule is an "adaptor" to turn natural amines into alkynes.

Use this product to enable any of your proteins for click chemistry.

This is an STP (sulfotetrafluorophenyl) ester. STP esters are similar to NHS esters, but possess higher hydrophilicity, and water solubility. It works fine in pure aqueous reactions without addition of organic co-solvent, and is best suited for the modification of proteins.

Calculator

Customers also purchased with this product

Pyrene azide 2

Pyrene azide with longer linker, for Click Chemistry.
Add this product to your cart and
get free express delivery

Cyanine5.5 carboxylic acid

Cy5.5 unactivated free acid cyanine dye.

Sulfo-Cyanine5.5 NHS ester

Water soluble, sulfonated, far-red sulfo-Cyanine5.5 dye in the form of NHS ester.

General properties

Appearance: colorless solid
Mass spec M+ increment: 80.0
Molecular weight: 348.20
CAS number: 1807530-14-8
Molecular formula: C11H5F4NaO5S
IUPAC name: 4-​Pentynoic acid, 2,​3,​5,​6-​tetrafluoro-​4-​sulfophenyl ester, sodium salt
Solubility: good in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Product citations

  1. Zanon, P.R.A.; Yu, F.; Musacchio, P.; Lewald, L.; Zollo, M.; Krauskopf, K.; Mrdović, D.; Raunft, P.; Maher, T.E.; Cigler, M.; Chang, C.; Lang, K.; Toste, F.D.; Nesvizhskii, A.I.; Hacker, S.M. Profiling the proteome-wide selectivity of diverse electrophiles. ChemRxiv, preprint. doi: 10.33774/chemrxiv-2021-w7rss-v2
  2. Abbasov, M.E.; Kavanagh, M.E.; Ichu, T.-A.; Lazear, M.R.; Tao, Y.; Crowley, V.M.; am Ende, C.W.; Hacker, S.M.; Ho, J.; Dix, M.M.; Suciu, R.; Hayward, M.M.; Kiessling, L.L.; Cravatt, B.F. A proteome-wide atlas of lysine-reactive chemistry. Nature Chemistry, 2021, 13(11), 1081–1092. doi: 10.1038/s41557-021-00765-4
  3. Antonov, S.A.; Novosadova, E.V.; Kobylansky, A.G.; Tarantul, V.Z.; Grivennikov, I.A. A Hybrid Detection Method Based on Peroxidase-mediated Signal Amplification and Click Chemistry for Highly Sensitive Background-free Immunofluorescent Staining. Journal of Histochemistry & Cytochemistry, 2019, 67(10), 771–782. doi: 10.1369/0022155419864113
  4. Jandl, B.; Sedghiniya, S.; Carstens, A.; Astakhova, K. Peptide–Fluorophore Hydrogel as a Signal Boosting Approach in Rapid Detection of Cancer DNA. ACS Omega, 2019, 4(9), 13889–13895. doi: 10.1021/acsomega.9b01586
Show more (2)
Your item has been added. View your cart or proceed to checkout
The count of items is incorrect.