Pentynoic acid STP ester

Cat. # Quantity Price Lead time
30720 10 mg $110.00 in stock
40720 25 mg $210.00 5 days
50720 50 mg $410.00 in stock
60720 100 mg $695.00 in stock

This water soluble alkyne activated ester reagent is used for the attachment of alkyne group to variois biomolecules such as proteins, and peptides. Amino-DNA, and other amines can be used as well. Since natural proteins do not contain alkynes, but almost always contain amines (lysines), this molecule is an "adaptor" to turn natural amines into alkynes.

Use this product to enable any of your proteins for Click Chemistry.

This is an STP (sulfotetrafluorophenyl) ester. STP esters are similar to NHS esters, but possess higher hydrophilicity, and water solubility. It works fine in pure aqueous reactions without addition of organic co-solvent, and is best suited for the modification of proteins.

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General properties

Appearance: colorless solid
Mass spec M+ increment: 80.0
Molecular weight: 348.20
CAS number: 1807530-14-8
Molecular formula: C11H5F4NaO5S
IUPAC name: 4-​Pentynoic acid, 2,​3,​5,​6-​tetrafluoro-​4-​sulfophenyl ester, sodium salt
Solubility: good in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download

Product citations

  1. Samuelsen, S.V.; Maity, A.; Nybo, M.; Macaubas, C.; Lønstrup, L.; Balboni, I.M.; Mellins, E.D.; Astakhova, K. Novel Phospholipid-Protein Conjugates Allow Improved Detection of Antibodies in Patients with Autoimmune Diseases. PLoS One, 2016, 11(6), e0156125. doi: 10.1371/journal.pone.0156125
  2. Maity, A.; Macaubas, C.; Mellins, E.; Astakhova, K. Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies. Molecules, 2015, 20(6), 10253–10263. doi: 10.3390/molecules200610253
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