Sulfo-Cyanine3 NHS ester

Cat. # Quantity Price Lead time
11320 1 mg $110.00 in stock
21320 5 mg $210.00 in stock
41320 25 mg $410.00 in stock
51320 50 mg $695.00 in stock
61320 100 mg $1190.00 in stock

Water soluble, amino-reactive sulfo-Cyanine3 NHS ester. Efficiently labels proteins and peptides in purely aqueous solution, without need for organic co-solvent. Ideal for proteins with low solubility, and proteins prone to denaturation.

This is sulfonated, hydrophilic and water-soluble dye. Non-sulfonated Cyanine3 NHS ester is also available.

This product is an analog of Cy3® NHS ester. Sulfo-Cyanine3 NHS ester replaces Cy3®, Alexa Fluor 546, and DyLight 549 for all applications.

Sulfo-Cyanine3 absorbance and emission spectra

Sulfo-Cyanine3 absorbance and emission spectra

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Sulfo-Cyanine5 carboxylic acid

Water-soluble Cyanine5 carboxylic acid, non-activated fluorescent dye.

Cyanine5.5 carboxylic acid

Cy5.5 unactivated free acid cyanine dye.

General properties

Appearance: dark red crystals
Molecular weight: 751.91
CAS number: 1424150-38-8 (sodium salt); 1424433-17-9, 1518643-34-9 (inner salt)
Molecular formula: C34H38N3KO10S2
IUPAC name: 3H-​Indolium, 2-​[3-​(1,​3-​dihydro-​1,​3,​3-​trimethyl-​5-​sulfo-​2H-​indol-​2-​ylidene)​-​1-​propen-​1-​yl]​-​1-​[6-​[(2,​5-​dioxo-​1-​pyrrolidinyl)​oxy]​-​6-​oxohexyl]​-​3,​3-​dimethyl-​5-​sulfo-​, inner salt, sodium salt
Solubility: soluble in water (0.62 M = 47 g/L), in polar organic solvents (DMF, DMSO)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 548
ε, L⋅mol−1⋅cm−1: 162000
Emission maximum, nm: 563
Fluorescence quantum yield: 0.1
CF260: 0.03
CF280: 0.06

Product citations

  1. Baker, Y.; Yuan, L.; Chen J.; Belle, R.; Carlisle, R.; El-Sagheer, A.; Brown, T. Expanding the Chemical Repertoire of DNA Nanomaterials Generated by Rolling Circle Amplification. ChemRxiv, preprint. doi: 10.26434/chemrxiv.12566963.v1
  2. Shramova, E.; Proshkina, G.; Shipunova, V.; Ryabova, A.; Kamyshinsky, R.; Konevega, A.; Schulga, A.; Konovalova, E.; Telegin, G.; Deyev, S. Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape. Cancers, 2020, 12(10), 3014. doi: 10.3390/cancers12103014
  3. Kang, J.; Lhee, S.; Lee, J.K.; Zare, R.N.; Nam, H.G. Restricted intramolecular rotation of fluorescent molecular rotors at the periphery of aqueous microdroplets in oil. Scientific Reports, 2020, 10, 16859. doi: 10.1038/s41598-020-73980-7
  4. Shuvalova, M.L.; Kopylov, A.T.; Mazurov, D.V.; Pichugin, A.V.; Bovin, N.V.; Filatov, A.V. CD44-Associated Tn Antigen as a New Biomarkerof Tumor Cells with Aberrant Glycosylation. Biochemistry (Moscow), 2020, 85(9), 1064–1071. doi: 10.1134/S0006297920090060
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