sulfo-Cyanine3 NHS ester

Cat. # Quantity Price Lead time
11320 1 mg $91 in stock
21320 5 mg $119 in stock
41320 25 mg $395 in stock
51320 50 mg $729 in stock
61320 100 mg $1290 in stock
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Water soluble, amino-reactive sulfo-Cyanine3 NHS ester that efficiently labels proteins and peptides in purely aqueous solution without needing organic co-solvent. Ideal for proteins with low solubility and proteins prone to denaturation.

This is the sulfonated, hydrophilic, and water-soluble dye. Non-sulfonated Cyanine3 NHS ester is also available.

This product is an analog of Cy3® NHS ester. sulfo-Cyanine3 NHS ester replaces Cy3® and DyLight 549 for all applications.

sulfo-Cyanine3 absorbance and emission spectra

sulfo-Cyanine3 absorbance and emission spectra

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General properties

Appearance: dark red crystals
Molecular weight: 751.91
CAS number: 1424150-38-8 (sodium salt); 1424433-17-9, 1518643-34-9 (inner salt)
Molecular formula: C34H38N3KO10S2
IUPAC name: 3H-​Indolium, 2-​[3-​(1,​3-​dihydro-​1,​3,​3-​trimethyl-​5-​sulfo-​2H-​indol-​2-​ylidene)​-​1-​propen-​1-​yl]​-​1-​[6-​[(2,​5-​dioxo-​1-​pyrrolidinyl)​oxy]​-​6-​oxohexyl]​-​3,​3-​dimethyl-​5-​sulfo-​, inner salt, sodium salt
Solubility: soluble in water (0.62 M = 47 g/L), in polar organic solvents (DMF, DMSO)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation/absorption maximum, nm: 548
ε, L⋅mol−1⋅cm−1: 162000
Emission maximum, nm: 563
Fluorescence quantum yield: 0.1
CF260: 0.03
CF280: 0.06

Product citations

  1. Yang, B.; Picchetti, P.; Wang, Y.; Wang, W.; Seeger, C.; Bozov, K.; Malik, S.; Mallach, D.; Schäfer, A.H.; Ibrahim, M.; Hirtz, M.; Powell, A.K. Patterned immobilization of polyoxometalate-loaded mesoporous silica particles via amine-ene Michael additions on alkene functionalized surfaces. Scientific Reports, 2024, 14, 1249. doi: 10.1038/s41598-023-50846-2
  2. Takahashi, S.; Homma, K. The molecular principles underlying diverse functions of the SLC26 family of proteins. The Journal of Biological Chemistry, 2024, 300(5), 107261. doi: 10.1016/j.jbc.2024.107261
  3. Zhao, J.; Elgeti, M.; O’Brien, E.S.; Sár, C.P.; EI Daibani, A.; Heng, J.; Sun, X.; White, E.; Che, T.; Hubbell, W.L.; Kobilka, B.K.; Chen, C. Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature, 2024, 629(8011), 474-480. doi: 10.1038/s41586-024-07295-2
  4. Carias, A.M.; Schneider, J.R.; Madden, P.; Lorenzo-Redondo, R.; Araínga, M.; Pegu, A.; Cianci, G.C.; Maric, D.; Villinger, F.; Mascola, J.R.; Veazey, R.S.; Hope, T.J. Anatomic distribution of intravenous injected IgG takes approximately 1 week to achieve stratum corneum saturation in vaginal tissues. The Journal of Immunology, 2023, 207(2), 505-511. doi: 10.4049/jimmunol.2100253
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