EdU (5-ethynyl-2'-deoxyuridine)

Cat. # Quantity Price Lead time
10540 100 mg $120.00 in stock
20540 250 mg $195.00 5 days
30540 500 mg $345.00 in stock
40540 1 g $590.00 in stock

EdU (ethynyldeoxyuridine) is a nucleoside, an analog of thymidine, carrying an ethynyl group. This nucleoside behaves as a substrate for cellular DNA replication machinery. Then, DNA containing ethynyl groups can be developed by Click chemistry reaction with various dye azides. Fluorescent DNA can be detected by microscopy, or cells can be sorted by FACS.

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General properties

Appearance: light beige to light brown solid
Molecular weight: 252.22
CAS number: 61135-33-9
Molecular formula: C11H12N2O5
Solubility: good in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks.
MSDS: Download
Product specifications

Product citations

  1. Wells, C.I.; Al-Ali, H.; Andrews, D.M.; Asquith, C.R.M.; Axtman, A.D.; Chung, M.; Dikic, I.; Ebner, D.; Elkins, J.M.; Ettmayer, P.; Fischer, C.; Frederiksen, M.; Gray, N.S.; Hatch, S.; Knapp, S.; Lee, S.; Lücking, U.; Michaelides, M.; Mills, C.E.; Müller, S.; Owen, D.; Picado, A.; Ramadan, K.; Saikatendu, K.S.; Schröder, M.; Stolz, A.; Tellechea, M.; Treiber, D.K.; Turunen, B.J.; Vilar, S.; Wang, J.; Zuercher, W.J.; Willson, T.M.; Drewry, D.H. The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification. bioRxiv, preprint. doi: 10.1101/2019.12.22.886523
  2. Gerosa, L.; Chidley, C.; Froehlich, F.; Sanchez, G.; Lim, S.K.; Muhlich, J.; Chen, J.-Y.; Baker, G.J.; Schapiro, D.; Shi, T.; Yi, L.; Nicora, C.D.; Claas, A.; Lauffenburger, D.A.; Qian, W.-J.; Wiley, H.S.; Sorger, P.K. Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells. bioRxiv, preprint. doi: 10.1101/762294
  3. Li, Z.; Pinch, B.J.; Olson, C.M.; Donovan, K.A.; Nowak, R.P.; Mills, C.E.; Scott, D.A.; Doctor, Z.M.; Eleuteri, N.A.; Chung, M.; Sorger, P.K.; Fischer, E.S.; Gray, N.S. Development and Characterization of a Wee1 Kinase Degrader. Cell Chemical Biology, 2020, 27(1), 57–65.e9. doi: 10.1016/j.chembiol.2019.10.013
  4. Wang, Z.; Cui, M.; Shah, A.M.; Ye, W.; Tan, W.; Min, Y.-L.; Botten, G.A.; Shelton, J.M.; Liu, N.; Bassel-Duby, R.; Olson, E.N. Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling. Proceedings of the National Academy of Sciences of the U.S.A., 2019, 116(37), 18455–18465. doi: 10.1073/pnas.1905824116
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