Thalidomide-carboxylic acid

Cat. # Quantity Price Lead time
4169-100mg 100 mg $160 in stock
4169-500mg 500 mg $510 in stock
4169-1g 1 g $740 in stock
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Thalidomide containing building block with carboxylic acid functionality for convenient PROTAC molecules assembly by attachment via 4-O-position thalidomide of amino-fictionalized linkers and ligands.

Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

There are several types of E3 ligases that are practically suitable for such a purpose. Thalidomide is the ligand capable of recruiting Cereblon (CRBN) E3 ligase.

General properties

Appearance: beige powder
Molecular weight: 332.27
CAS number: 1061605-21-7
Molecular formula: C15H12N2O7
Solubility: DMF, DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
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