THPTA ligand

Cat. # Quantity Price Lead time
F4050 100 mg $65.00 in stock
H4050 500 mg $199.00 in stock
I4050 1 g $369.00 in stock
K4050 5 g $1568.00 in stock

THPTA ligand (tris-hydroxypropyltriazolylmethylamine) is a triazole ligand for water-based copper-catalyzed click chemistry reactions. This reagent is very well water-soluble. It is especially useful for click chemistry labeling and conjugation of proteins, including antibodies, when organic co-solvents are undesirable.

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THPTA ligand

THPTA is a water-soluble ligand for Cu(I)-catalyzed click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.

General properties

Appearance: off white solid
Molecular weight: 434.5
CAS number: 760952-88-3
Molecular formula: C18H30N10O3
IUPAC name: 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol
Solubility: good in water, DMF, DMSO
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks.
MSDS: Download
Product specifications

Product citations

  1. Soxpollard, N.; Strauss, S.; Jungmann, R.; MacPherson, I. Selection of Antibody-Binding Covalent Aptamers. bioRxiv, 2023, preprint. doi: 10.1101/2023.03.09.530504
  2. Slapak, E.J.; el Mandili, M.; Brink, M.S.T.; Kros, A.; Bijlsma, M.F.; Spek, C.A. Preclinical Assessment of ADAM9-Responsive Mesoporous Silica Nanoparticles for the Treatment of Pancreatic Cancer. International Journal of Molecular Sciences, 2023, 24(13), 10704. doi: 10.3390/ijms241310704
  3. Ramey-Ward, A.N.; Dong, Y.; Yang, J.; Ogasawara, H.; Bremer-Sai, E.C.; Brazhkina, O.; Franck, C.; Davis, M.; Salaita, K. Optomechanically Actuated Hydrogel Platform for Cell Stimulation with Spatial and Temporal Resolution. ACS Biomaterials Science & Engineering, 2023, 9(9), 5361-5375. doi: 10.1021/acsbiomaterials.3c00516
  4. Salazar-Chaparro, A. F.; Halder, S.; Trader, D. J. Synthesis and Application of a Clickable Epoxomicin-Based Probe for Proteasome Activity Analysis. Current Protocols, 2022, 2(7), e490. doi: 10.1002/cpz1.490
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