THPTA ligand

Click chemistry
Cat. # Quantity Price Lead time
F4050 100 mg $50.00 in stock
H4050 500 mg $250.00 in stock
I4050 1 g $370.00 in stock
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THPTA ligand (tris-hydroxypropyltriazolylmethylamine) is a triazole ligand for water based copper catalyzed Click chemistry reactions. This reagent is very well water soluble. It is especially useful for Click chemistry labeling and conjugation of proteins including antibodies, when organic co-solvents are undesirable.

THPTA ligand
THPTA ligand
THPTA ligand
Structure of THPTA ligand
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General properties

Appearance: off white solid
Molecular weight: 434.5
CAS number: 760952-88-3
Molecular formula: C18H30N10O3
IUPAC name: 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol
Solubility: good in water, DMF, DMSO
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks.
MSDS: Download
Product specifications

Product citations

  1. Ramey-Ward, A.N.; Su, H.; Salaita, K. Mechanical stimulation of adhesion receptors using light-responsive nanoparticle actuators enhances myogenesis. ACS Applied Materials & Interfaces, 2020, 12(32), 35903–35917. doi: 10.1021/acsami.0c08871
  2. Hahn, F.; Niesar, A.; Wangen, C.; Wild, M.; Grau, B.; Herrmann, L.; Capci, A.; Adrait, A.; Couté, Y.; Tsogoeva, S.B.; Marschall, M. Target verification of artesunate-related antiviral drugs: assessing the role of mitochondrial and regulatory proteins by click chemistry and fluorescence labeling. Antiviral Research, 2020, 180, 104861. doi: 10.1016/j.antiviral.2020.104861
  3. Kleinpenning, F.; Steigenberger, B.; Wu, W.; Heck, A.J.R. Fishing for newly synthesized proteins with phosphonate-handles. Nature Communications, 2020, 11, 3244. doi: 10.1038/s41467-020-17010-0
  4. Zhou, J.; Wang, W.; Zhang, J.; Du, Z.; Yang, H.; Zhang, G. Click chemistry-based imaging to study tissue distribution of curcumin-protein complex in mice. Food & Function, 2020, 11(2), 1684–1691. doi: 10.1039/c9fo02012h
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