THPTA ligand

Click chemistry

Cat. #	Quantity	Price	Lead time
F4050	100 mg	$65	in stock
H4050	500 mg	$199	in stock
I4050	1 g	$369	in stock
K4050	5 g	$1568	in stock

Found better price? Let us know and we will propose the way forward!

THPTA ligand (tris-hydroxypropyltriazolylmethylamine) is a triazole ligand for water-based copper-catalyzed click chemistry reactions. This reagent is very well water-soluble. It is especially useful for click chemistry labeling and conjugation of proteins, including antibodies, when organic co-solvents are undesirable.

Download in
ChemDraw format

Customers also purchased with this product

Universal CPG type II, 1000A

This universal support is intended for automated synthesis of oligonucleotides to accelerate the dephosphorylation process during deblocking. Pore size of 1000 Å is recommended for the synthesis of oligonucleotides up to 120 bases.

EdU (5-Ethynyl-2'-deoxyuridine)

EdU is a nucleoside that is incorporated into replicated DNA by cellular enzymes. After it, DNA contained in the cells can be developed by click chemistry reaction with fluorescent dye azides to reveal cell proliferation.

Cyanine5 azide

Cyanine5 azide is a reagent for click chemistry labeling with Cyanine5, a popular fluorescent dye.

Add this product to your cart and
get free express delivery

General properties

Appearance:	off white solid
Molecular weight:	434.5
CAS number:	760952-88-3
Molecular formula:	C₁₈H₃₀N₁₀O₃
IUPAC name:	3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol
Solubility:	good in water, DMF, DMSO
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks.
MSDS:	Download
	Product specifications

Product citations

Slapak, E.J.; el Mandili, M.; Ten Brink, M.S.; Kros, A.; Bijlsma, M.F.; Spek, C.A. CAPN2-responsive mesoporous silica nanoparticles: A promising nanocarrier for targeted therapy of pancreatic cancer. Cancer Letters, 2024, 590, 216845. doi: 10.1016/j.canlet.2024.216845
Narum, S.; Deal, B.; Ogasawara, H.; Mancuso, J. N.; Zhang, J.; Salaita, K. An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids. ACS Nano, 2024, 18(8), 6186–6201. doi: 10.1021/acsnano.3c09027
Cardenas, A. J.; Thomas, K. S.; Broden, M. W.; Ferraro, N. J.; Pires, M. M.; John, C. M.; Jarvis, G. A.; Criss, A. K. Neisseria Gonorrhoeae Scavenges Host Sialic Acid for Siglec-Mediated, Complement-Independent Suppression of Neutrophil Activation. mBio, 2024, 15(5), e00119-24. doi: 10.1128/mbio.00119-24
Soxpollard, N.; Strauss, S.; Jungmann, R.; MacPherson, I. S. Selection of Antibody-Binding Covalent Aptamers. Commun Chem, 2024, 7(1), 1-11. doi: 10.1038/s42004-024-01255-7