THPTA ligand

Cat. # Quantity Price Lead time
F4050 100 mg $50.00 in stock
H4050 500 mg $250.00 in stock
I4050 1 g $370.00 in stock

THPTA ligand (tris-hydroxypropyltriazolylmethylamine) is a triazole ligand for water based copper catalyzed Click chemistry reactions. This reagent is very well water soluble. It is especially useful for Click chemistry labeling and conjugation of proteins including antibodies, when organic co-solvents are undesirable.

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General properties

Appearance: off white solid
Molecular weight: 434.5
CAS number: 760952-88-3
Molecular formula: C18H30N10O3
IUPAC name: 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol
Solubility: good in water, DMF, DMSO
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks.
MSDS: Download
Product specifications

Product citations

  1. Sundah, N.R.; Ho, N.R.Y.; Lim, G.S.; Natalia, A.; Ding, X.; Liu, Y.; Seet, J.E.; Chan, C.W.; Loh, T.P.; Shao, H. Barcoded DNA nanostructures for the multiplexed profiling of subcellular protein distribution. Nature Biomedical Engineering, 2019, 3(9), 684–694. doi: 10.1038/s41551-019-0417-0
  2. Yang, H.; Sukamtoh, E.; Du, Z.; Wang, W.; Ando, M.; Kwakwa, Y.N.; Zhang, J.; Zhang, G. Click chemistry approach to characterize curcumin-protein interactions in vitro and in vivo}. The Journal of Nutritional Biochemistry, 2019, 68, 1–6. doi: 10.1016/j.jnutbio.2019.02.010
  3. Wilder, L.M.; Fies, W.A.; Rabin, C.; Webb, L.J.; Crooks, R.M. Conjugation of an α-Helical Peptide to the Surface of Gold Nanoparticles. Langmuir, 2019, 35(9), 3363–3371. doi: 10.1021/acs.langmuir.9b00075
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