THPTA ligand
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
F4050 | 100 mg | $65.00 | in stock | |
H4050 | 500 mg | $199.00 | in stock | |
I4050 | 1 g | $369.00 | in stock | |
K4050 | 5 g | $1568.00 | in stock |
THPTA ligand (tris-hydroxypropyltriazolylmethylamine) is a triazole ligand for water-based copper-catalyzed click chemistry reactions. This reagent is very well water-soluble. It is especially useful for click chemistry labeling and conjugation of proteins, including antibodies, when organic co-solvents are undesirable.
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THPTA is a water-soluble ligand for Cu(I)-catalyzed click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.General properties
Appearance: | off white solid |
Molecular weight: | 434.5 |
CAS number: | 760952-88-3 |
Molecular formula: | C18H30N10O3 |
IUPAC name: | 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol |
Solubility: | good in water, DMF, DMSO |
Quality control: | NMR 1H, HPLC-MS (95%) |
Storage conditions: | Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. |
MSDS: | Download |
Product specifications |
Product citations
- Soxpollard, N.; Strauss, S.; Jungmann, R.; MacPherson, I. Selection of Antibody-Binding Covalent Aptamers. bioRxiv, 2023, preprint. doi: 10.1101/2023.03.09.530504
- Slapak, E.J.; el Mandili, M.; Brink, M.S.T.; Kros, A.; Bijlsma, M.F.; Spek, C.A. Preclinical Assessment of ADAM9-Responsive Mesoporous Silica Nanoparticles for the Treatment of Pancreatic Cancer. International Journal of Molecular Sciences, 2023, 24(13), 10704. doi: 10.3390/ijms241310704
- Ramey-Ward, A.N.; Dong, Y.; Yang, J.; Ogasawara, H.; Bremer-Sai, E.C.; Brazhkina, O.; Franck, C.; Davis, M.; Salaita, K. Optomechanically Actuated Hydrogel Platform for Cell Stimulation with Spatial and Temporal Resolution. ACS Biomaterials Science & Engineering, 2023, 9(9), 5361-5375. doi: 10.1021/acsbiomaterials.3c00516
- Salazar-Chaparro, A. F.; Halder, S.; Trader, D. J. Synthesis and Application of a Clickable Epoxomicin-Based Probe for Proteasome Activity Analysis. Current Protocols, 2022, 2(7), e490. doi: 10.1002/cpz1.490
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