Cyanine5 maleimide

Cat. # Quantity Price Lead time
13080 1 mg $110.00 in stock
23080 5 mg $210.00 in stock
43080 25 mg $410.00 in stock
53080 50 mg $695.00 in stock
63080 100 mg $1190.00 in stock

Cyanine5 maleimide is a mono-reactive dye which selectively couples with thiol groups (for example, with cysteines in peptides and proteins) to give labeled conjugates.

Cyanine5 is an analog of Cy5®, a common fluorophore which is compatible with various instrumentation like microscopes, imagers, and fluorescence readers.

For the labeling of antibodies and sensitive proteins we recommend to use the water soluble sulfo-Cyanine5 maleimide.

Cy5 excitation and emission spectra

Cy5 excitation and emission spectra

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BDP 630/650 maleimide

BDP 630/650 maleimide is a thiol reactive, borondipyrromethene based dye tuned to match the far red channel of Cyanine5 fluorophore.

Sulfo-Cyanine5 alkyne

Sulfo-Cyanine5 is a water-soluble Cyanine5 dye alkyne for Click chemistry.

BDP 630/650 carboxylic acid

BDP 630/650 is a bright fluorophore for far red part of the spectrum. This dye is perfect for microscopy and fluorescence polarization assays. This is a carboxylic acid that can be activated for the coupling, or used as a control.
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General properties

Appearance: dark blue powder
Molecular weight: 641.24
CAS number: 1437872-46-2 (without anion), 1437796-65-0 (chloride)
Molecular formula: C38H45ClN4O3
IUPAC name: 3H-​Indolium, 2-​[5-​[1-​[6-​[[2-​(2,​5-​dihydro-​2,​5-​dioxo-​1H-​pyrrol-​1-​yl)​ethyl]​amino]​-​6-​oxohexyl]​-​1,​3-​dihydro-​3,​3-​dimethyl-​2H-​indol-​2-​ylidene]​-​1,​3-​pentadien-​1-​yl]​-​1,​3,​3-​trimethyl-
Solubility: soluble in organic solvents (DMF, DMSO, dichloromethane), practically insoluble in water (31 uM, 23 mg/L)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 646
ε, L⋅mol−1⋅cm−1: 250000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.2
CF260: 0.03
CF280: 0.04

Product citations

  1. Turker, M.Z.; Gardinier, T.C.; Hinckley, J.A.; Contreras, C.B.; Woodruff, F.; Ma, K.; Kohle, F.F.E.; Wiesner, U.B. Inner and Outer Surface Functionalizations of Ultrasmall Fluorescent Silica Nanorings As Shown by High-Performance Liquid Chromatography. Chemistry of Materials, in press. doi: 10.1021/acs.chemmater.9b01236
  2. Ast, J.; Arvaniti, A.; Fine, N.H.F.; Nasteska, D.; Ashford, F.B.; Stamataki, Z.M Koszegi, Z.; Bacon, A.; Trapp, S.; Jones, B.J.; Hastoy, B.; Tomas, A.; Reissaus, C.; Linnemann, A.K.; D'Este, E.; Calebiro, D.; Johnsson, K.; Podewin, T.; Broichhagen, J.; Hodson, D.J. LUXendins reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. bioRxiv, preprint. doi: 10.1101/557132
  3. Catipovic, M.A.; Bauer, B.W.; Loparo, J.J.; Rapoport, T.A. Protein translocation by the SecA ATPase occurs by a power-stroke mechanism. EMBO Journal, 2019, 38(9), e101140. doi: 10.15252/embj.2018101140
  4. Armache, J.P.; Gamarra, N.; Johnson, S.L.; Leonard, J.D.; Wu, S.; Narlikar, G.J.; Cheng, Y. Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome. eLife, 2019, 8, e46057. doi: 10.7554/eLife.46057
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