Cyanine5 maleimide

Cat. # Quantity Price Lead time
13080 1 mg $110.00 in stock
23080 5 mg $210.00 in stock
43080 25 mg $410.00 in stock
53080 50 mg $695.00 in stock
63080 100 mg $1190.00 in stock

Cyanine5 maleimide is a mono-reactive dye which selectively couples with thiol groups (for example, with cysteines in peptides and proteins) to give labeled conjugates.

Cyanine5 is an analog of Cy5®, a common fluorophore which is compatible with various instrumentation like microscopes, imagers, and fluorescence readers.

For the labeling of antibodies and sensitive proteins we recommend to use the water soluble sulfo-Cyanine5 maleimide.

Cy5 excitation and emission spectra

Cy5 excitation and emission spectra

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Cyanine5.5 alkyne

Cyanine5.5 alkyne is a NIR (near infrared) dye azide for both copper-catalyzed, and copper-free Click Chemistry.

Sulfo-Cyanine5 alkyne

Sulfo-Cyanine5 is a water-soluble Cyanine5 dye alkyne for Click chemistry.

Cyanine5 carboxylic acid

Cyanine5 carboxylic acid, unactivated dye.
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General properties

Appearance: dark blue powder
Molecular weight: 641.24
CAS number: 1437872-46-2 (without anion), 1437796-65-0 (chloride)
Molecular formula: C38H45ClN4O3
IUPAC name: 3H-​Indolium, 2-​[5-​[1-​[6-​[[2-​(2,​5-​dihydro-​2,​5-​dioxo-​1H-​pyrrol-​1-​yl)​ethyl]​amino]​-​6-​oxohexyl]​-​1,​3-​dihydro-​3,​3-​dimethyl-​2H-​indol-​2-​ylidene]​-​1,​3-​pentadien-​1-​yl]​-​1,​3,​3-​trimethyl-
Solubility: soluble in organic solvents (DMF, DMSO, dichloromethane), insoluble in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 646
ε, L⋅mol−1⋅cm−1: 250000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.2
CF260: 0.03
CF280: 0.04

Product citations

  1. Gagni, P.; Romanato, A.; Bergamaschi, G.; Bettotti, P.; Vanna, R.; Piotto, C.; Morasso, C.F.; Chiari, M.; Cretich, M.; Gori, A. A self-assembling peptide hydrogel for ultrarapid 3D bioassays. Nanoscale Advances, in press. doi: 10.1039/c8na00158h
  2. Wu, B.; Zhang, H.; Sun, R.; Peng, S.; Cooperman, B.S.; Goldman, Y.E.; Chen, C. Translocation kinetics and structural dynamics of ribosomes are modulated by the conformational plasticity of downstream pseudoknots. Nucleic Acids Research, 2018, 46(18), 9736–9748. doi: 10.1093/nar/gky636
  3. Khor, S.Y.; Vu, M.N.; Pilkington, E.H.; Johnston, A.P.R.; Whittaker, M.R.; Quinn, J.F.; Truong, N.P.; Davis, T.P. Elucidating the Influences of Size, Surface Chemistry, and Dynamic Flow on Cellular Association of Nanoparticles Made by Polymerization-Induced Self-Assembly. Small, 2018, 14(34), e1801702. doi: 10.1002/smll.201801702
  4. Chambre, L.; Degirmenci, A.; Sanyal, R.; Sanyal, A. Multifunctional Nanogels as Theranostic Platforms: Exploiting Reversible and Non-reversible Linkages for Targeting, Imaging and Drug Delivery. Bioconjugate Chemistry, 2018, 29(6), 1885–1896. doi: 10.1021/acs.bioconjchem.8b00085
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