AF 568 DBCO

AF 568 Cycloalkynes Copper-free click chemistry

Cat. #	Quantity	Price	Lead time
1158F0	1 mg	$140	in stock
2158F0	5 mg	$450	in stock
4158F0	25 mg	$1460	in stock
5158F0	50 mg	$1890	in stock
6158F0	100 mg	$2990	in stock

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Dibenzocyclooctyne (DBCO, DBCO, ADIBO) is one of the most reactive cycloalkynes for copper-free click reaction (SPAAC, strain-promoted azide-alkyne cycloaddition). The rate of interaction of DBCO with azides is significantly higher than that of other cyclooctynes, as well as Cu-catalyzed click reaction (CuAAC). Unlike other cyclooctynes, DBCO does not interact with tetrazines, which makes it possible to use it in bioorthogonal reactions together with trans-cyclooctenes and tetrazines.

AF 568 is a bright, photostable, and hydrophilic fluorophore that emits in the orange channel. The absorption maximum is 572 nm. The emission maximum is 598 nm.

AF 568 DBCO allows fluorescent labeling of azide-containing biomolecules inside living cells and whole organisms without the negative effect of copper ions on them, and inanimate samples.

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Absorption and emission spectra of AF 568

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BDP® 558/568 DBCO

BDP 558/568 DBCO is a bright and photostable dye with emission in the yellow spectrum range. It contains a cyclooctyne substituting group (i.e. DBCO), which can react with various azides in Click Chemistry reactions.

BDP® 650/665 DBCO

This red-fluorescent dye contains a substituting group for copper-free click chemistry.

AF 488 alkyne

Alkyne derivative of AF 488 dye for copper-catalyzed cycloaddition to azides. Pure 5-isomer.

General properties

Appearance:	dark violet solid
Molecular weight:	1197.53
Molecular formula:	C₆₆H₈₀N₆O₁₁S₂
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light.
MSDS:	Download
	Product specifications

Spectral properties

Excitation/absorption maximum, nm:	572
ε, L⋅mol⁻¹⋅cm⁻¹:	94238
Emission maximum, nm:	598
Fluorescence quantum yield:	0.912

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.