AmdU (5-azidomethyl-2'-deoxyuridine)

Azides Copper free Click chemistry
Cat. # Quantity Price Lead time
B1540 5 mg $120.00 in stock
D1540 25 mg $255.00 in stock
F1540 100 mg $890.00 in stock
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Azidomethyl-dU (AmdU) is a nucleoside that contains an azide group. The structure of the nucleoside is similar to thymidine, and it is incorporated into nascent DNA by cellular polymerases, similarly to EdU.

Unlike EdU that needs to be further modified with azides in the presence of copper catalyst, AmdU can also react in the absence of copper catalyst using spAAC Click Chemistry with strained cycloalkynes, such as cyclooctynes. This enables detection of nascent DNA in benign, copper free conditions.

Structure of AmdU (azidomethyldeoxyuridine)
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General properties

Appearance: white / off white solid
Molecular weight: 283.24
Molecular formula: C10H13N5O5
IUPAC name: 5-Azidomethyl-2'-deoxyuridine
Solubility: good in water, alcohols, DMSO, DMF
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
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