sulfo-Cyanine3 tetrazine

Tetrazines Copper-free click chemistry sulfo-Cyanine3

Cat. #	Quantity	Price	Lead time
113E0	1 mg	$125	in stock
213E0	5 mg	$325	in stock
313E0	10 mg	$470	in stock
413E0	25 mg	$850	in stock
513E0	50 mg	$1490	in stock
613E0	100 mg	$1990	in stock

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Tetrazine-trans-cyclooctene ligation is among the fastest bioconjugation reactions known to date.

This water-soluble sulfo-Cyanine3 derivative contains methyltetrazine moiety for the coupling with trans-cyclooctenes. Methyltetrazines possess optimal stability at physiological pH, while maintaining extremely high reactivity towards cyclooctenes.

The fluorophore is bright, photostable, and is also very well visible with naked eye.

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Absorption and emission spectra of Cyanine3

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THPTA ligand

THPTA is a water-soluble ligand for Cu(I)-catalyzed click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.

BDP® FL tetrazine

BDP FL tetrazine (methyltetrazine) is a reactive dye for the inverse electron demand Diels-Alder (IEDDA) reaction with trans-cyclooctenes, cyclopropenes, and other strained cycloolefines. BDP FL is a bright and photostable dye for the 488 nm fluorescein (FAM) channel.

General properties

Appearance:	red powder
Molecular weight:	838.05
Molecular formula:	C₄₀H₄₄KN₇O₇S₂
IUPAC name:	Potassium (E)-2-[(E)-3-{3,3-Dimethyl-1-[6-({[p-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}amino)-6-oxohexyl]-5-(oxysulfonyl)-3H-indol-2-yl}-2-propenylidene]-1-methyl-3,3-dimethyl-5-indolinesulfonate
Solubility:	soluble in water (0.43 M = 36 g/L), DMF, DMSO
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download
	Product specifications

Spectral properties

Excitation/absorption maximum, nm:	548
ε, L⋅mol⁻¹⋅cm⁻¹:	162000
Emission maximum, nm:	563
Fluorescence quantum yield:	0.1
CF₂₆₀:	0.03
CF₂₈₀:	0.06

Cy® is a trademark of GE Healthcare.

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.