VdU (5-Vinyl-2'-deoxyuridine)
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
B2540 | 5 mg |
–
|
in stock | |
D2540 | 25 mg |
$225
|
in stock | |
F2540 | 100 mg |
$785
|
in stock |
VdU (5-Vinyl-2’-deoxyuridine) is a synthetic analog of thymidine that can be used to study de novo DNA synthesis and cell proliferation. It is a potential replacement for BrdU (5-Bromo-2’-deoxyuridine) or EdU (5-Ethynyl-2’-deoxyuridine).
VdU incorporates into replicating DNA during the S-phase of the cell cycle instead of natural thymidine. The resulting vinyl-functionalized DNA can be detected by introducing either a biotin or fluorescent dye group via a cooper-free alkene-tetrazine reaction (also known as Inverse electron demand Diels-Alder ligation or IEDDA) and used for subsequent DNA purification or cell imaging tasks.
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Stable fluorophore that can be conjugated with trans-cyclooctene derivatives of biomolecules for their visualization.EdU (5-Ethynyl-2'-deoxyuridine)
EdU is a nucleoside that is incorporated into replicated DNA by cellular enzymes. After it, DNA contained in the cells can be developed by click chemistry reaction with fluorescent dye azides to reveal cell proliferation.General properties
Appearance: | yellowish solid |
Molecular weight: | 254.24 |
CAS number: | 55520-67-7 |
Molecular formula: | C11H14N2O5 |
Solubility: | in DMSO |
Quality control: | NMR 1H and HPLC-MS (95+%) |
Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
MSDS: | Download |
Product specifications |
