THPTA ligand

Click chemistry

Cat. #	Quantity	Price	Lead time
F4050	100 mg	$98.00	in stock
H4050	500 mg	$199.90	in stock
I4050	1 g	$379.90	5 days
K4050	5 g	$1650.00	5 days

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THPTA ligand (tris-hydroxypropyltriazolylmethylamine) is a triazole ligand for water-based copper-catalyzed click chemistry reactions. This reagent is very well water-soluble. It is especially useful for click chemistry labeling and conjugation of proteins, including antibodies, when organic co-solvents are undesirable.

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General properties

Appearance:	off white solid
Molecular weight:	434.5
CAS number:	760952-88-3
Molecular formula:	C₁₈H₃₀N₁₀O₃
IUPAC name:	3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol
Solubility:	good in water, DMF, DMSO
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks.
MSDS:	Download
	Product specifications

Product citations

Ford, A. L.; Taft, C. W.; Sprague-Getsy, A. M.; Carlson, G. C.; Mate, N. A.; Sieburg, M. A.; Chisholm, J. D.; Hougland, J. L. A Modular Customizable Ligand-Conjugate (LC) System Targeting Ghrelin O-Acyltransferase. Biomolecules, 2025, 15(2), 204. doi: 10.3390/biom15020204
van Bergen, W.; Nederstigt, A. E.; Heck, A. J. R.; Baggelaar, M. P. Site-Specific Competitive Kinase Inhibitor Target Profiling Using Phosphonate Affinity Tags. Molecular & Cellular Proteomics, 2025, 24(2), 100906. doi: 10.1016/j.mcpro.2025.100906
Slapak, E.J.; el Mandili, M.; Ten Brink, M.S.; Kros, A.; Bijlsma, M.F.; Spek, C.A. CAPN2-responsive mesoporous silica nanoparticles: A promising nanocarrier for targeted therapy of pancreatic cancer. Cancer Letters, 2024, 590, 216845. doi: 10.1016/j.canlet.2024.216845
Narum, S.; Deal, B.; Ogasawara, H.; Mancuso, J. N.; Zhang, J.; Salaita, K. An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids. ACS Nano, 2024, 18(8), 6186–6201. doi: 10.1021/acsnano.3c09027