Cyanine5 amine

Cat. # Quantity Price Lead time
130C0 1 mg $110.00 in stock
230C0 5 mg $210.00 in stock
430C0 25 mg $410.00 in stock
530C0 50 mg $695.00 in stock
630C0 100 mg $1190.00 in stock

Cyanine5 amine is a reactive dye which contains amino group, an analog of Cy5® amine. This reagent can be coupled with a variety of activated esters and other electrophilic reagents. For example, this amine can be coupled with EDC-activated carboxylic groups.

This bright and photostable dye is suitable for many different methods of fluorescence detection. Colorful fluorophore can also be easily detected in small quantities (nanomols) by naked human eye.

Cyanine5 amine absorbance and emission spectra

Cyanine5 amine absorbance and emission spectra

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General properties

Appearance: dark blue powder
Molecular weight: 653.77
CAS number: 1807589-58-7 (without anion), 1807529-70-9 (chloride)
Molecular formula: C38H54Cl2N4O
IUPAC name: 3H-​Indolium, 2-​[5-​[1-​[6-​[(6-​aminohexyl)​amino]​-​6-​oxohexyl]​-​1,​3-​dihydro-​3,​3-​dimethyl-​2H-​indol-​2-​ylidene]​-​1,​3-​pentadien-​1-​yl]​-​1,​3,​3-​trimethyl-
Solubility: moderate solubility in water, good in polar organic solvents (DMF, DMSO, alcohols)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 646
ε, L⋅mol−1⋅cm−1: 250000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.2
CF260: 0.03
CF280: 0.04

Product citations

  1. Sarparanta, M.; Pourat, J.; Carnazza, K.E.; Tang, J.; Paknejad, N.; Reiner, T.; Kostiainen, M.A.; Lewis, J.S. Multimodality labeling strategies for the investigation of nanocrystalline cellulose biodistribution in a mouse model of breast cancer. Nuclear Medicine and Biology, in press. doi: 10.1016/j.nucmedbio.2019.11.002
  2. Zhou, L.; Wu, Y.; Luo, Y.; Li, H.; Meng, X.; Liu, Cl; Xiang, J.; Zhang, P.; Gong, P.; Cai, L. Mitochondria-localized Self-reporting Small Molecule Decorated Theranostic Agents for Cancer-organelle Transporting and Imaging. ACS Applied Bio Materials, in press. doi: 10.1021/acsabm.9b00811
  3. Zhang, T.; Lip, H.; He, C.; Cai, P.; Wang, Z.; Henderson, J.T.; Rauth, A.M.; Wu, X.Y. Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages. Advanced Healthcare Materials, 2019, 8(18), 1900543. doi: 10.1002/adhm.201900543
  4. Mahmoud, A.; de Jongh, P.; Briere, S.; Chen, M.Z.; Nowell, C.J.; Johnston, A.P.R.; Davis, T.P.; Haddleton, D.M.; Kempe, K. Carboxylated Cy5-labeled Comb Polymers Passively Diffuse the Cell Membrane and Target Mitochondria. ACS Applied Materials & Interfaces, 2019, 11(34), 31302–31310. doi: 10.1021/acsami.9b09395
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