Cyanine7 NHS ester

Cat. # Quantity Price Lead time
15020 1 mg $110.00 in stock
25020 5 mg $210.00 in stock
45020 25 mg $410.00 in stock
55020 50 mg $695.00 in stock
65020 100 mg $1190.00 in stock

Amine reactive Cyanine7, near infrared fluorescent dye, an improved analog of Cy7®.

NIR fluorophores can be used to take advantage of near infrared window of biological tissues - increased transparency of tissues in this spectral region allows to carry out in vivo imaging.

This reagent can be utilized to produce Cyanine7-labeled biomolecules for subsequent use in various in vivo research, and drug design related experiments.

The structure of Cyanine7 features rigidized design of central polymethyne chain. This molecular reinforcement allows to increase quantum yield by 20% compared with parent structure, increasing fluorescence brightness.

This reagent requires organic co-solvent for the labeling (please see Recommended Protocols section below). Water-soluble Cyanine7 NHS ester is also available, and recommended for protein NIR labeling.

Cy7 absorbance and emission spectra

Cy7 absorbance and emission spectra

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Pyrenebutyric acid NHS ester

Pyrene NHS ester for the labeling of biomolecules with pyrene residue. Pyrene is a fluorescent proximity probe which forms excimers, and it is also an anchor group for graphite immobilization.

General properties

Appearance: dark green solid
Molecular weight: 733.64
CAS number: 1432019-64-1 (chloride), 1432466-81-3 (without anion)
Molecular formula: C41H48N3BF4O4
IUPAC name: 1‐{6‐[(2,5‐dioxopyrrolidin‐1‐yl)oxy]‐6‐oxohexyl}‐ 3,3‐dimethyl‐2‐[(E)‐2‐[(3E)‐3‐{2‐[(2E)‐1,3,3‐ trimethyl‐2,3‐dihydro‐1H‐indol‐2‐ ylidene]ethylidene}cyclohex‐1‐en‐1‐yl]ethenyl]‐3H‐ indol‐1‐ium tetrafluoroborate
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 750
ε, L⋅mol−1⋅cm−1: 199000
Emission maximum, nm: 773
Fluorescence quantum yield: 0.3
CF260: 0.022
CF280: 0.029

Product citations

  1. Huang, C.; Zeng, T.; Li, J.; Tan, L.; Deng, X.; Pan, Y.; Chen, Q.; Li, A.; Hu, J. Folate Receptor-mediated Renal-targeting Nanoplatform for the Specific Delivery of Triptolide to Treat Renal Ischemia/Reperfusion Injury. ACS Biomaterials Science & Engineering, in press. doi: 10.1021/acsbiomaterials.9b00119
  2. Dahanayake, V.; Pornrungroj, C.; Pablico-Lansigan, M.; Hickling, W.J.; Lyons, T.; Lah, D.; Lee, Y.-C.; Parasido, E.; Bertke, J.A.; Albanese, C.; Rodriguez, O.; Van Keuren, E.; Stoll, S.L. Paramagnetic Clusters of Mn3(O2CCH3)6(Bpy)2 in Polyacrylamide Nanobeads as a New Design Approach to T1-T2 Multi-Modal MRI Contrast Agent. ACS Applied Materials & Interfaces, 2019, 11(20), 18153–18164. doi: 10.1021/acsami.9b03216
  3. Phillips, H.R.; Tolstyka, Z.P.; Hall, B.C.; Hexum, J.K.; Hackett, P.B.; Reineke, T.M. Glycopolycation-DNA Polyplex Formulation N/P Ratio Affects Stability, Hemocompatibility, and in Vivo Biodistribution. Biomacromolecules, 2019, 20(4), 1530–1544. doi: 10.1021/acs.biomac.8b01704
  4. Crawford, B.M.; Strobbia, P.; Wang, H.-N.; Zentella, R.; Boyanov, M.I.; Pei, Z.-M.; Sun, T.-P.; Kemner, K.M.; Vo-Dinh, T. Plasmonic nanoprobes for in vivo multimodal sensing and bioimaging of microRNA within plants. ACS Applied Materials & Interfaces, 2019, 11(8), 7743–7754. doi: 10.1021/acsami.8b19977
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