Cyanine7 NHS ester
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 15020 | 1 mg | $110.00 | in stock | |
| 25020 | 5 mg | $210.00 | in stock | |
| 45020 | 25 mg |
$410.00
|
in stock | |
| 55020 | 50 mg |
$695.00
|
in stock | |
| 65020 | 100 mg |
$1190.00
|
in stock |
Amine reactive Cyanine7, near infrared fluorescent dye, an improved analog of Cy7®.
NIR fluorophores can be used to take advantage of near infrared window of biological tissues - increased transparency of tissues in this spectral region allows to carry out in vivo imaging.
This reagent can be utilized to produce Cyanine7-labeled biomolecules for subsequent use in various in vivo research, and drug design related experiments.
The structure of Cyanine7 features rigidized design of central polymethyne chain. This molecular reinforcement allows to increase quantum yield by 20% compared with parent structure, increasing fluorescence brightness.
This reagent requires organic co-solvent for the labeling (please see Recommended Protocols section below). Water-soluble Cyanine7 NHS ester is also available, and recommended for protein NIR labeling.
Cy7 absorbance and emission spectra
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Recommended protocol
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Sulfo-Cyanine7 amine
Water-soluble NIR dye amine, sulfonated derivative of Cyanine7 dye, for the modification via enzymatical transamination.General properties
| Appearance: | dark green solid |
| Molecular weight: | 733.64 |
| CAS number: | 1432019-64-1 (chloride), 1432466-81-3 (without anion) |
| Molecular formula: | C41H48N3BF4O4 |
| IUPAC name: | 1‐{6‐[(2,5‐dioxopyrrolidin‐1‐yl)oxy]‐6‐oxohexyl}‐ 3,3‐dimethyl‐2‐[(E)‐2‐[(3E)‐3‐{2‐[(2E)‐1,3,3‐ trimethyl‐2,3‐dihydro‐1H‐indol‐2‐ ylidene]ethylidene}cyclohex‐1‐en‐1‐yl]ethenyl]‐3H‐ indol‐1‐ium tetrafluoroborate |
| Solubility: | soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water |
| Quality control: | NMR 1H, HPLC-MS (95%) |
| Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation maximum, nm: | 750 |
| ε, L⋅mol−1⋅cm−1: | 199000 |
| Emission maximum, nm: | 773 |
| Fluorescence quantum yield: | 0.3 |
| CF260: | 0.022 |
| CF280: | 0.029 |
Product citations
- Chen, J.; Guo, Y.; Li, H.; Zhang, C.; Chang, X.; Ma, R.; Cheng, H.; Ye, X.; Cui, H.; Li, Y. Near-infrared dye-labeled antibody COC183B2 enables detection of tiny metastatic ovarian cancer and optimizes fluorescence-guided surgery. Journal of Surgical Oncology, in press. doi: 10.1002/jso.26130
- Huang, Y.; Jiang, K.; Zhang, X.; Chung, E.J. The Effect of Size, Charge, and Peptide Ligand Length on Kidney Targeting by Small, Organic Nanoparticles. Bioengineering & Translational Medicine, in press. doi: 10.1002/btm2.10173
- Poreba, M.; Groborz, K.; Rut, W.; Pore, M.; Snipas, S.J.; Vizovisek, M.; Turk, B.; Kuhn, P.; Drag, M.; Salvesen, G.S. The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes). bioRxiv, preprint. doi: 10.1101/775627
- Zhou, Y.; Zhu, X.; Lin, S.; Zhu, C.; Wu, L.; Chen, R.; Chen, Z.; Li, W. A Novel Nanoparticle Preparation to Enhance the Gastric Adhesion and Bioavailability of Xanthatin. International Journal of Nanomedicine, 2020, 15, 5073–5082. doi: 10.2147/IJN.S252049
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