Cyanine7 NHS ester
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 15020 | 1 mg | $110.00 | in stock | |
| 25020 | 5 mg | $210.00 | in stock | |
| 45020 | 25 mg |
$410.00
|
in stock | |
| 55020 | 50 mg |
$695.00
|
in stock | |
| 65020 | 100 mg |
$1190.00
|
in stock |
Amine reactive Cyanine7, near infrared fluorescent dye, an improved analog of Cy7®.
NIR fluorophores can be used to take advantage of near infrared window of biological tissues - increased transparency of tissues in this spectral region allows to carry out in vivo imaging.
This reagent can be utilized to produce Cyanine7-labeled biomolecules for subsequent use in various in vivo research, and drug design related experiments.
The structure of Cyanine7 features rigidized design of central polymethyne chain. This molecular reinforcement allows to increase quantum yield by 20% compared with parent structure, increasing fluorescence brightness.
This reagent requires organic co-solvent for the labeling (please see Recommended Protocols section below). Water-soluble Cyanine7 NHS ester is also available, and recommended for protein NIR labeling.
Cy7 absorbance and emission spectra
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Recommended protocol
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Cyanine7 carboxylic acid
Non-reactive, near-infrared fluorescent dye.BDP TMR azide
Borondipyrromethene dye with azido group. Spectral properties are similar to TAMRA dye. Due to long fluorescence lifetime, BDP TMR is especially useful for fluorescence polarization measurements.Alkyne-PEG3-COOH
Bifunctional linker with terminal alkyne function, and carboxylic acid moiety, CAS# 1415800-32-6.General properties
| Appearance: | dark green solid |
| Molecular weight: | 733.64 |
| CAS number: | 1432019-64-1 (chloride), 1432466-81-3 (without anion) |
| Molecular formula: | C41H48N3BF4O4 |
| IUPAC name: | 1‐{6‐[(2,5‐dioxopyrrolidin‐1‐yl)oxy]‐6‐oxohexyl}‐ 3,3‐dimethyl‐2‐[(E)‐2‐[(3E)‐3‐{2‐[(2E)‐1,3,3‐ trimethyl‐2,3‐dihydro‐1H‐indol‐2‐ ylidene]ethylidene}cyclohex‐1‐en‐1‐yl]ethenyl]‐3H‐ indol‐1‐ium tetrafluoroborate |
| Solubility: | soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water |
| Quality control: | NMR 1H, HPLC-MS (95%) |
| Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation maximum, nm: | 750 |
| ε, L⋅mol−1⋅cm−1: | 199000 |
| Emission maximum, nm: | 773 |
| Fluorescence quantum yield: | 0.3 |
| CF260: | 0.022 |
| CF280: | 0.029 |
Product citations
- Smith, W.J.; Wang, G.; Gaikwad, H.; Vu, V.P.; Groman, E.; Bourne, D.W.A.; Simberg, D. Accelerated Blood Clearance of Antibodies by Nanosized Click Antidotes. ACS Nano, 2018, 12(12), 12523–12532. doi: 10.1021/acsnano.8b07003
- Li, W.; Li, Y.; Liu, Z.; Kerdsakundee, N.; Zhang, M.; Zhang, F.; Liu, X.; Bauleth-Ramos, T.; Lian, W.; Mäkilä, E.; Kemell, M.; Ding, Y.; Sarmento, B.; Wiwattanapatapee, R.; Salonen, J.; Zhang, H.; Hirvonen, J.T.; Liu, D.; Deng, X.; Santos, H.A. Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine. Biomaterials, 2018, 185, 322–332. doi: 10.1016/j.biomaterials.2018.09.024
- Besford, Q.A.; Ju, Y.; Wang, T.-Y.; Yun, G.; Cherepanov, P.V.; Hagemeyer, C.E.; Cavalieri, F.; Caruso, F. Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles. Small, 2018, 14(39), e1802342. doi: 10.1002/smll.201802342
- Etrych, T.; Daumová, L.; Pokorná, E.; Tušková, D.; Lidický, O.; Kolářová, V.; Pankrác, J.; Šefc, L.; Chytil, P.; Klener, P. Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging. Journal of Controlled Release, 2018, 289, 44–55. doi: 10.1016/j.jconrel.2018.09.018
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