Cyanine7 NHS ester
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 15020 | 1 mg | $110.00 | in stock | |
| 25020 | 5 mg | $210.00 | in stock | |
| 45020 | 25 mg |
$410.00
|
in stock | |
| 55020 | 50 mg |
$695.00
|
in stock | |
| 65020 | 100 mg |
$1190.00
|
in stock |
Amine reactive Cyanine7, near infrared fluorescent dye, an improved analog of Cy7®.
NIR fluorophores can be used to take advantage of near infrared window of biological tissues - increased transparency of tissues in this spectral region allows to carry out in vivo imaging.
This reagent can be utilized to produce Cyanine7-labeled biomolecules for subsequent use in various in vivo research, and drug design related experiments.
The structure of Cyanine7 features rigidized design of central polymethyne chain. This molecular reinforcement allows to increase quantum yield by 20% compared with parent structure, increasing fluorescence brightness.
This reagent requires organic co-solvent for the labeling (please see Recommended Protocols section below). Water-soluble Cyanine7 NHS ester is also available, and recommended for protein NIR labeling.
Cy7 absorbance and emission spectra
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Recommended protocol
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General properties
| Appearance: | dark green solid |
| Molecular weight: | 733.64 |
| CAS number: | 1432019-64-1 (chloride), 1432466-81-3 (without anion) |
| Molecular formula: | C41H48N3BF4O4 |
| IUPAC name: | 1‐{6‐[(2,5‐dioxopyrrolidin‐1‐yl)oxy]‐6‐oxohexyl}‐ 3,3‐dimethyl‐2‐[(E)‐2‐[(3E)‐3‐{2‐[(2E)‐1,3,3‐ trimethyl‐2,3‐dihydro‐1H‐indol‐2‐ ylidene]ethylidene}cyclohex‐1‐en‐1‐yl]ethenyl]‐3H‐ indol‐1‐ium tetrafluoroborate |
| Solubility: | soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water |
| Quality control: | NMR 1H, HPLC-MS (95%) |
| Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation maximum, nm: | 750 |
| ε, L⋅mol−1⋅cm−1: | 199000 |
| Emission maximum, nm: | 773 |
| Fluorescence quantum yield: | 0.3 |
| CF260: | 0.022 |
| CF280: | 0.029 |
Product citations
- Poreba, M.; Groborz, K.; Rut, W.; Pore, M.; Snipas, S.J.; Vizovisek, M.; Turk, B.; Kuhn, P.; Drag, M.; Salvesen, G.S. The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes). bioRxiv, preprint. doi: 10.1101/775627
- Zheng, Q.; Fang, Y.; Zeng, L.; Li, X.; Chen, H.; Song, H.; Huang, J.; Shi, S. Cytocompatible cerium oxide-mediated antioxidative stress in inhibiting ocular inflammation-associated corneal neovascularization. Journal of Materials Chemistry B, 2019, 7(43), 6759–6769. doi: 10.1039/c9tb01066a
- Xu, C.; Yu, Y.; Sun, Y.; Kong, L.; Yang, C.; Hu, M.; Yang, T.; Zhang, J.; Hu, Q.; Zhang, Z. Transformable Nanoparticle-Enabled Synergistic Elicitation and Promotion of Immunogenic Cell Death for Triple-Negative Breast Cancer Immunotherapy. Advanced Functional Materials, 2019, 29(45), 1905213. doi: 10.1002/adfm.201905213
- Poreba, M.; Groborz, K.; Vizovisek, M.; Maruggi, M.; Turk, D.; Turk, B.; Powis, G.; Drag, M.; Salvesen, G.S. Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples. Chemical Science, 2019, 10(36), 8461–8477. doi: 10.1039/c9sc00997c
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