Cyanine5.5 amine

Cat. # Quantity Price Lead time
170C0 1 mg $110.00 in stock
270C0 5 mg $210.00 in stock
470C0 25 mg $410.00 in stock
570C0 50 mg $695.00 in stock
670C0 100 mg $1190.00 in stock

Cyanine5.5 (Cy5.5® analog) amine derivative. The dye contains a free amine group which can be conjugated with a variety of functionalities, including NHS esters, and epoxides.

Cyanine5.5 is a far red dye which works fine for live organism imaging, and applications requiring low fluorescence background.

Cy5.5 absorbance and emission spectra

Cy5.5 absorbance and emission spectra

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Sulfo-Cyanine5.5 NHS ester

Water soluble, sulfonated, far-red sulfo-Cyanine5.5 dye in the form of NHS ester.

General properties

Appearance: dark blue powder
Molecular weight: 753.88
CAS number: 2097714-44-6 (without anion), 2097714-45-7 (chloride)
Molecular formula: C46H58Cl2N4O
IUPAC name: 1H-​Benz[e]​indolium, 2-​[5-​[3-​[6-​[(6-​aminohexyl)​amino]​-​6-​oxohexyl]​-​1,​3-​dihydro-​1,​1-​dimethyl-​2H-​benz[e]​indol-​2-​ylidene]​-​1,​3-​pentadien-​1-​yl]​-​1,​1,​3-​trimethyl-
Solubility: practically insoluble in water (< 2 uM), good in polar organic solvents (DMF, DMSO, alcohols)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 684
ε, L⋅mol−1⋅cm−1: 198000
Emission maximum, nm: 710
Fluorescence quantum yield: 0.2
CF260: 0.07
CF280: 0.03

Product citations

  1. Zhang, E.; Zhukova, V.; Semyonkin, A.; Osipova, N.; Malinovskaya, Y.; Maksimenko, O.; Chernikov, V.; Sokolov, M.; Grigartzik, L.; Sabel, B.A.; Gelperina, S.; Henrich-Noack, P. Release kinetics of fluorescent dyes from PLGA nanoparticles in retinal blood vessels: in vivo monitoring and ex vivo localization. European Journal of Pharmaceutics and Biopharmaceutics, 2020, 150, 131–142. doi: 10.1016/j.ejpb.2020.03.006
  2. Maksimenko, O.; Malinovskaya, Y.; Shipulo, E.; Osipova, N.; Razzhivina, V.; Arantseva, D.; Yarovaya, O.; Mostovaya, U.; Khalansky, A.; Fedoseeva, V.; Alekseeva, A.; Vanchugova, L.; Gorshkova, M.; Kovalenko, E.; Balabanyan, V.; Melnikov, P.; Baklaushev, V.; Chekhonin, V.; Kreuter, J.; Gelperina, S. Doxorubicin-loaded PLGA nanoparticles for the chemotherapy of glioblastomas: Towards the pharmaceutical development. International Journal of Pharmaceutics, 2019, 572, 118733. doi: 10.1016/j.ijpharm.2019.118733
  3. Park, J.; Zhang, Y.; Saito, E.; Gurczynski, S.J.; Moore, B.B.; Cummings, B.J.; Anderson, A.J.; Shea, L.D. Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury. Proceedings of the National Academy of Sciences of the U.S.A., 2019, 116(30), 14947–14954. doi: 10.1073/pnas.1820276116
  4. Saito, E.; Kuo, R.; Kramer, K.R.; Gohel, N.; Giles, D.A.; Moore, B.B.; Miller, S.D.; Shea, L.D. Design of biodegradable nanoparticles to modulate phenotypes of antigen presenting cells for antigen-specific treatment of autoimmune disease. Biomaterials, 2019, 222, 119432. doi: 10.1016/j.biomaterials.2019.119432
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