Cyanine5.5 amine

Cat. # Quantity Price Lead time
170C0 1 mg $110.00 in stock
270C0 5 mg $210.00 in stock
470C0 25 mg $410.00 in stock
570C0 50 mg $695.00 in stock
670C0 100 mg $1190.00 in stock

Cyanine5.5 (Cy5.5® analog) amine derivative. The dye contains a free amine group which can be conjugated with a variety of functionalities, including NHS esters, and epoxides.

Cyanine5.5 is a far red dye which works fine for live organism imaging, and applications requiring low fluorescence background.

Cy5.5 absorbance and emission spectra

Cy5.5 absorbance and emission spectra

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General properties

Appearance: dark blue powder
Molecular weight: 753.88
CAS number: 2097714-44-6 (without anion), 2097714-45-7 (chloride)
Molecular formula: C46H58Cl2N4O
IUPAC name: 1H-​Benz[e]​indolium, 2-​[5-​[3-​[6-​[(6-​aminohexyl)​amino]​-​6-​oxohexyl]​-​1,​3-​dihydro-​1,​1-​dimethyl-​2H-​benz[e]​indol-​2-​ylidene]​-​1,​3-​pentadien-​1-​yl]​-​1,​1,​3-​trimethyl-
Solubility: practically insoluble in water (< 2 uM), good in polar organic solvents (DMF, DMSO, alcohols)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 684
ε, L⋅mol−1⋅cm−1: 198000
Emission maximum, nm: 710
Fluorescence quantum yield: 0.2
CF260: 0.07
CF280: 0.03

Product citations

  1. Seo, J.-H.; Lee, S.Y.; Hwang, C.; Yang, M.; Lee, J.; Lee, S.-H.; Cho, H.-J. Multi-layered cellulose nanocrystal system for CD44 receptor-positive tumor-targeted anticancer drug delivery. International Journal of Biological Macromolecules, 2020, 162, 798–809. doi: 10.1016/j.ijbiomac.2020.06.193
  2. Safari, H.; Kelley, W.J.; Saito, E.; Kaczorowski, N.; Carethers, L.; Shea, L.D.; Eniola-Adefeso, O. Neutrophils preferentially phagocytose elongated particles {\textendash} An opportunity for selective targeting in acute inflammatory diseases. Science Advances, 2020, 6(24), eaba1474. doi: 10.1126/sciadv.aba1474
  3. Zhang, E.; Zhukova, V.; Semyonkin, A.; Osipova, N.; Malinovskaya, Y.; Maksimenko, O.; Chernikov, V.; Sokolov, M.; Grigartzik, L.; Sabel, B.A.; Gelperina, S.; Henrich-Noack, P. Release kinetics of fluorescent dyes from PLGA nanoparticles in retinal blood vessels: in vivo monitoring and ex vivo localization. European Journal of Pharmaceutics and Biopharmaceutics, 2020, 150, 131–142. doi: 10.1016/j.ejpb.2020.03.006
  4. Han, W.; Shi, L.; Xie, B.; Wan, J.; Ren, L.; Wang, Y.; Chen, X.; Wang, H. Supramolecular Engineering of Molecular Inhibitors in an Adaptive Cytotoxic Nanoparticle for Synergistic Cancer Therapy. ACS Applied Materials & Interfaces, 2020, 12(1), 1707–1720. doi: 10.1021/acsami.9b20178
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