Alkyne-PEG3-carboxylic acid
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
1743-1g | 1 g | $490 | in stock | |
1743-5g | 5 g | $980 | in stock | |
1743-25g | 25 g | please inquire | in stock |
Alkyne-PEG3-carboxylic acid is a bifunctional triethyleneglycol derivative bearing a carboxy group and an alkyne moiety. The former can be activated with peptide coupling reagents like PyBOP or carbodiimides like EDC to form a stable amide linkage with amines. The alkyne group can be coupled with azides in a CuAAC reaction.
PEGs are hydrophilic linkers useful in synthesizing water-soluble conjugates.
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A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)General properties
Appearance: | colorless to yellow oil |
Molecular weight: | 246.26 |
CAS number: | 1415800-32-6 |
Molecular formula: | C11H18O6 |
IUPAC name: | 3,6,9,12-tetraoxapentadecyn-15-oic acid |
Solubility: | good in most organic solvents and water |
Quality control: | NMR 1H, GC-MS (95%, as Me ester) |
Storage conditions: | Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate. |
MSDS: | Download |
Product specifications |
Product citations
- Petrov, R.A.; Mefedova, S.R.; Yamansarov, E.Y.; Maklakova, S.Y.; Grishin, D.A.; Lopatukhina, E.V.; Burenina, O.Y.; Lopukhov, A.V.; Kovalev, S.V.; Timchenko, Y.V.; Ondar, E.E.; Ivanenkov, Y.A.; Evteev, S.A.; Vaneev, A.N.; Timoshenko, R.V.; Klyachko, N.L.; Erofeev, A.S.; Gorelkin, P.V.; Beloglazkina, E.K.; Majouga, A.G. New Small-Molecule Glycoconjugates of Docetaxel and GalNAc for Targeted Delivery to Hepatocellular Carcinoma. Molecular Pharmaceutics, 2021, 18(1), 461–468. doi: 10.1021/acs.molpharmaceut.0c00980
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