Alkyne amidite, hydroxyprolinol

Alkynes Oligonucleotide synthesis Phosphoramidites Click chemistry
Cat. # Quantity Price Lead time
21360 250 mg $110 in stock
41360 1 g $390 in stock
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Phosphoramidite for the synthesis of alkyne-modified oligonucleotides. Oligonucleotides can be used for сlick сhemistry modification (see the protocol).

Diluent for this amidite is acetonitrile, 5 min coupling time is recommended. Standard deprotection conditions can be used for oligonucleotides.

Oligonucleotides can be purified by HPLC or cartridges due to the presence of dimethoxytrityl group, as well as by PAGE.

Alkyne Amidite, hydroxyprolinol
Alkyne amidite structure
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General properties

Appearance: colorless semisolid
Molecular weight: 713.84
CAS number: 1357289-02-1
Molecular formula: C41H52N3O6P
IUPAC name: Phosphoramidous acid, N,​N-​bis(1-​methylethyl)​-​, (3R,​5S)​-​5-​[[bis(4-​methoxyphenyl)​phenylmethoxy]​methyl]​-​1-​(1-​oxo-​5-​hexyn-​1-​yl)​-​3-​pyrrolidinyl 2-​cyanoethyl ester
Solubility: good in acetonitrile and dichloromethane
Quality control: NMR 1H and 31P, HPLC-MS (95 %)
Storage conditions: Storage: 12 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications

Oligo synthesis details

Diluent: acetonitrile
Coupling conditions: standard coupling, identical to normal nucleobases
Deprotection conditions: identical to protected nucleobases
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