FAM CPG 500, 6-isomer

FAM (Fluorescein) CPG modifier solid supports Oligonucleotide synthesis

Cat. #	Quantity	Price	Lead time
15760	100 mg	$95	in stock
35760	500 mg	$295	in stock
45760	1 g	$469	in stock
55760	5 g	please inquire	in stock

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Controlled pore glass solid supports are used for the synthesis of 3'-labeled oligonucleotides. This solid support is intended for the synthesis of oligonucleotides bearing fluorescein (FAM) fluorescent dye on the 3'-terminus of oligonucleotide. It contains pure 6-isomer of fluorescein. The structure of the reagent is based on a chiral, enantiomerically pure scaffold of hydroxyprolinol.

The solid support ensures optimal yield of oligonucleotides up to 60mer. For longer oligos, CPG 1000 should be used. The reagent is compatible with standard ammonia cleavage and deblocking conditions.

Structure of FAM CPG modifier 500, 6-isomer

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General properties

Appearance:	off white beads
Quality control:	NMR ¹H and loading measurement, functional testing in oligo synthesis.
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download
	Product specifications

Oligo synthesis details

Pore size, Å:	500
Typical loading, umol/g:	65±15
Coupling conditions:	standard coupling, identical to normal nucleobases
Cleavage conditions:	ammonia, 2 h at room temperature
Deprotection conditions:	identical to protected nucleobases

Product citations

Zharkov, T.D.; Mironova, E.M.; Markov, O.V.; Zhukov, S.A.; Khodyreva, S.N.; Kupryushkin, M.S. Fork- and Comb-like Lipophilic Structures: Different Chemical Approaches to the Synthesis of Oligonucleotides with Multiple Dodecyl Residues. International Journal of Molecular Sciences, 2023, 24(19), 14637. doi: 10.3390/ijms241914637

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.