CDr17 M1 Macrophage Stain
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 5292-1mg | 1 mg |
$279.00
|
in stock |
CDr17 is a selective small-molecule fluorescent probe designed for the identification and tracking of M1 macrophages. The labeling method is based on the higher expression of the GLUT1 transporter in M1 (pro-inflammatory) macrophages compared to M0 (resting) and M2 (anti-inflammatory) macrophages. CDr17 probe is composed of a glucose scaffold and a 2-position Cyanine5 fluorophore, and due to this, it is taken up into cells specifically through the GLUT1 transporter. The CDr17 accumulation is directly proportional to GLUT1 expression levels.
CDr17 has been demonstrated to track M1 macrophages in vivo in a rheumatoid arthritis animal model [1].
[1] Cho H. et al. Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target. Nat. Commun. 2022. 13. 5974.
Excitation and emission spectra of LumiCell CDr17
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General properties
| Appearance: | blue powder |
| Molecular weight: | 745.66 |
| Molecular formula: | C39H52BF4N3O6 |
| Solubility: | soluble in organic solvents (DMF, DMSO, dichloromethane), very poorly soluble in water |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation/absorption maximum, nm: | 646 |
| Emission maximum, nm: | 662 |
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