AF 488 TCO

AF 488 Cycloalkenes Copper-free click chemistry
Cat. # Quantity Price Lead time
118H0 1 mg $199 5 days
218H0 5 mg $649 5 days
418H0 25 mg $1789 5 days
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Trans-cyclooctene (TCO) is one of the most used cycloalkenes for bioconjugation tasks. TCO readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.

This TCO is a AF 488-containing derivative. AF 488 is sulfonated rhodamine, a bright, photostable, and hydrophilic fluorophore that emits in the green channel. The absorption maximum is 495 nm. The emission maximum is 519 nm.

AF 488 TCO, 418H0
AF 488 TCO, 418H0
AF 488 TCO, 418H0
Structure of AF 488 TCO
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Absorption and emission spectra of AF 488

Absorption and emission spectra of AF 488

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Biotin-PEG4-tetrazine

Biotin tetrazine is a reagent for copper-free click chemistry labeling with biotin, a well-known affinity probe to streptavidin.

General properties

Appearance: orange powder
Molecular weight: 989.27
Molecular formula: C48H70N6O12S2
Solubility: good in water, DMSO; moderate in acetonitrile
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light.
MSDS: Download
Product specifications

Spectral properties

Excitation/absorption maximum, nm: 495
ε, L⋅mol−1⋅cm−1: 71800
Emission maximum, nm: 519
Fluorescence quantum yield: 0.91
CF260: 0.16
CF280: 0.10
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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