Cyanine3B TCO
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 139H0 | 1 mg |
$590.00
|
in stock |
Cyanine3B TCO is a derivative of the Cyanine3B dye functionalized with trans-cyclooctene (TCO) for rapid and selective conjugation to tetrazine-containing biomolecules.
The dye belongs to the cyanine family of orange-red fluorophores and is characterized by high molar absorptivity, high fluorescence quantum yield, and improved photostability compared to conventional Cyanine3. Cyanine3B provides bright and stable fluorescence signals in fluorescence microscopy, flow cytometry, FRET experiments, and super-resolution imaging applications.
The TCO moiety reacts rapidly and selectively with tetrazines without the need for catalysts via the inverse electron-demand Diels—Alder (IEDDA) reaction, enabling biomolecule labeling under mild conditions, including in live cells. The reaction features by fast kinetics, excellent biocompatibility, and minimal background signal.
Product in action
Absorbance and emission spectra of Cyanine3B
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General properties
| Appearance: | red powder |
| Molecular weight: | 811.06 |
| Molecular formula: | C46H58N4O7S |
| Solubility: | DMSO, DMF, acetonitrile |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation/absorption maximum, nm: | 559 |
| ε, L⋅mol−1⋅cm−1: | 121000 |
| Emission maximum, nm: | 571 |
| Fluorescence quantum yield: | 0.68 |
| CF260: | 0.044 |
| CF280: | 0.077 |
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